Phosphonate terminated PPH dendrimers: influence of pendant alkyl chains on the in vitro anti-HIV-1 properties

Pérez-Anes, Alexandra; Spataro, Grégory; Coppel, Yannick; Moog, Christiane; Blanzat, Muriel; Turrin, Cédric‐Olivier; Caminade, Anne‐Marie; Rico‐Lattes, Isabelle; Majoral, Jean‐Pierre

doi:10.1039/b908352a

Cited by 42 publications

(30 citation statements)

References 25 publications

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“…In particular, we used polyamidoamine dendrimers with ethylenediamine core and branches of methyl acrylate and ethylenediamine, as well as dendrimers based on phosphorus [12,15].…”

Section: Resultsmentioning

confidence: 99%

“…The following cationic polymers were used for transfection: linear polyethylenimine ExGen500 (Fermentas), fourth-generation polyamidoamine dendrimers PAMAM-NH 2 G4 (Dendritic NanoTechnologies) and fourth-generations phosphorus dendrimers (Phos G4) [5,12,15]. Formation of DNA-polycation complexes was conducted in 150 mM NaCl at a charge ratio of 1:1 (for PEI ExGen500 according to manufacturer's recommendation), transfection was carried out for 2 h in culture medium containing 10% serum.…”

Section: Methodsmentioning

confidence: 99%

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Neurons and Stromal Stem Cells as Targets for Polycation-Mediated Transfection

et al. 2011

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Expression of transgenes in neurons and stromal/mesenchymal stem cells (MSC) can greatly enhance their therapeutic potential. In transfection experiments, we studied properties of linear and branched (dendrimers) polycations as transgene delivery vehicles. Linear polyethyleneimine transfected neurons, but was ineffective in MSC. Polyamidoamine dendrimers showed greater transfection efficiency and mean GFP fluorescence intensity compared to phosphorus dendrimers of the same (4th) generation. Expression of neurotrophic factor BDNF in MSC transfected with polyamidoamine dendrimers was also by more than 10 times higher.

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“…In particular, we used polyamidoamine dendrimers with ethylenediamine core and branches of methyl acrylate and ethylenediamine, as well as dendrimers based on phosphorus [12,15].…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Neurons and Stromal Stem Cells as Targets for Polycation-Mediated Transfection

et al. 2011

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“…Blanzat et al have evaluated anti-HIV potential of phosphorus dendrimers based on hexachlorocyclotriphosphazene or thiophosphoryltrichloride core in a series of investigations [80–82]. Phosphorous dendrimers with either cinnamic acid or phosphonic acid end groups were prepared.…”

Section: Nano-architectures For Hiv Prophylaxismentioning

confidence: 99%

“…Thus, this series of dendrimers was deemed to be unsuitable for further development. The same group designed phosphonate terminated poly-(phosphorhydrazone) dendrimers with different pendant alkyl chains [82]. Unlike earlier investigation, no attempts were made to fabricate cataninonic dendrimers.…”

Section: Nano-architectures For Hiv Prophylaxismentioning

confidence: 99%

A review of nanotechnological approaches for the prophylaxis of HIV/AIDS

Date

Destache

2013

Biomaterials

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Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century. More than 33 million individuals are infected with HIV worldwide and more than 2 million new cases of HIV infection have been reported. The situation demands development of effective prevention strategies to control the pandemic of AIDS. Due to lack of availability of an effective HIV vaccine, antiretroviral drugs and nucleic acid therapeutics like siRNA have been explored for HIV prophylaxis. Clinical trials shave shown that antiretroviral drugs, tenofovir and emtricitabine can offer some degree of HIV prevention. However, complete prevention of HIV infection has not been achieved yet. Nanotechnology has brought a paradigm shift in the diagnosis, treatment and prevention of many diseases. The current review discusses potential of various nanocarriers such as dendrimers, polymeric nanoparticles, liposomes, lipid nanocarriers, drug nanocrystals, inorganic nanocarriers and nanofibers in improving efficacy of various modalities available for HIV prophylaxis.

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“…Biological properties of water-soluble phosphorhydrazone dendrimers 39 (around 2 10 -5 mol.L -1 ), whereas that of the dendrimer having a C 3 alkyl chain was found to be 10 fold better (1.6 10 -6 mol.L -1 ) (Perez-Anes et al, 2009).…”

Section: Phosphorhydrazone Dendrimers En-ded By Phosphonate Groupsmentioning

confidence: 99%

Biological properties of water-soluble phosphorhydrazone dendrimers

Caminade

Turrin

Majoral

2013

Braz. J. Pharm. Sci.

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1984-8250Dendrimers are hyperbranched and perfectly defined macromolecules, constituted of branches emanating from a central core in an iterative fashion. Phosphorhydrazone dendrimers constitute a special family of dendrimers, possessing one phosphorus atom at each branching point. The internal structure of these dendrimers is hydrophobic, but hydrophilic terminal groups can induce the solubility of the whole structure in water. Indeed, the properties of these compounds are mainly driven by the type of terminal groups their bear; this is especially true for the biological properties. For instance, positively charged terminal groups are efficient for transfection experiments, as drug carriers, as anti-prion agents, and as inhibitor of the aggregation of Alzheimer's peptides, whereas negatively charged dendrimers have anti-HIV properties and can influence the human immune system, leading to anti-inflammatory properties usable against rheumatoid arthritis. This review will give the most representative examples of the biological properties of water-soluble phosphorhydrazone dendrimers, organized depending on the type of terminal groups they bear

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Phosphonate terminated PPH dendrimers: influence of pendant alkyl chains on the in vitro anti-HIV-1 properties

Abstract: The synthesis, characterization and in vitro anti-HIV activity of a series of generation one dendrimers having phosphonate groups with pendant alkyl chains are described. The influence of the lateral alkyl chains on the biological properties was correlated to (1)H-(1)H NOESY experiments.

Cited by 42 publications

References 25 publications

Neurons and Stromal Stem Cells as Targets for Polycation-Mediated Transfection

Neurons and Stromal Stem Cells as Targets for Polycation-Mediated Transfection

A review of nanotechnological approaches for the prophylaxis of HIV/AIDS

Biological properties of water-soluble phosphorhydrazone dendrimers

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