Phosphor for phototherapy: Review on psoriasis

Hemne, P. S.; Kunghatkar, R. G.; Dhoble, S.J.; Moharil, S. V.; Singh, Vijay

doi:10.1002/bio.3266

Cited by 20 publications

(8 citation statements)

References 39 publications

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“…UVA is normally in the wavelength range from 320 to 400 nm and causes skin tanning effects. UVB is in the range from 280 to 320 nm and causes sunburn (erythema) [ 3 ]. UVA is known to damage DNA, protein and lipids.…”

Section: Introductionmentioning

confidence: 99%

Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2

Liang

Peng

et al. 2018

Cell Mol Biol Lett

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BackgroundLycium barbarum polysaccharide (LBP) is considered an antioxidant agent. NF-E2-related factor-2 (Nrf2) is an important regulator for protection against UV damage. In this study, we verified the performance of LBP and the correlation between LBP and Nrf2.MethodsHSF cells were treated with LBP to determine dose and time dependencies. An antioxidant response element (ARE) reporter was designed to monitor the activity of the Nrf2 antioxidant pathway.ResultsFor HSF cells, the optimal LBP treatment was 300 μg/ml for 3 h. The ARE-reporter assay showed that LBP could increase the robustness of p-Nrf2. Treatments with genistein and LY294002 reduced of nuclear p-Nrf2 after 24 h. LBP increased the level of nuclear Nrf2, which functions by both phosphorylation and nuclear translocation. Silencing Nrf2 led to increased reactive oxygen species (ROS) levels, lower cell viability, and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSP-PX) levels. This induced a higher level of lipid peroxide (LPO). However, LBP could decrease the levels of ROS and LPO and enhance the levels of SOD and GSP-PX.ConclusionLBP protects HSF cells against UV damage via the regulation of Nrf2.

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Section: Introductionmentioning

confidence: 99%

Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2

Liang

Peng

et al. 2018

Cell Mol Biol Lett

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“…Psoriasis is a highly recurrent skin immune disease characterized by skin lesions. The incidence in the world is about 0.1–3%, and 5 million people suffer from this disease in China . The symptoms of psoriasis are mainly reflected in the epidermal proliferation and inflammatory cell infiltration, accompanied by rapid proliferation and differentiation of keratinocytes, over‐angiogenesis in dermal papillary as well as T cell infiltration .…”

Section: Introductionmentioning

confidence: 99%

“…The incidence in the world is about 0.1–3%, and 5 million people suffer from this disease in China . The symptoms of psoriasis are mainly reflected in the epidermal proliferation and inflammatory cell infiltration, accompanied by rapid proliferation and differentiation of keratinocytes, over‐angiogenesis in dermal papillary as well as T cell infiltration . The complex pathogenesis of psoriasis is a result of genetic inheritance, immune, infection and other related factors which still cannot be fully clarified .…”

Section: Introductionmentioning

confidence: 99%

IL‐35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells

Wang

Mao

Zhang

et al. 2017

J Cellular Molecular Medi

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Interleukin-35 (IL-35), a member of the IL-12 family, functions as a new anti-inflammatory factor involved in arthritis, psoriasis, inflammatory bowel disease (IBD) and other immune diseases. Although IL-35 can significantly prevent the development of inflammation in many diseases, there have been no early studies accounting for the role of IL-35 recombinant protein in IBD and psoriasis. In this study, we assessed the therapeutic potential of IL-35 recombinant protein in three well-known mouse models: the dextransulfate sodium ( Further analysis demonstrated that IL-35 recombinant protein may regulate inflammation through promoting the secretion of IL-10 and inhibiting the expression of pro-inflammatory cytokines such as IL-6, TNF-a and IL-17 in acute colitis model. In addition, lower dose of IL-35 recombinant protein could achieve long-term treatment effects as TNF-a monoclonal antibody did in the psoriasis mouse. In summary, the remarkable therapeutic effects of IL-35 recombinant protein in acute colitis and psoriasis mouse models indicated that IL-35 recombinant protein had a variety of anti-inflammatory effects and was expected to become an effective candidate drug for the treatment of inflammatory diseases.

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“…The key cytotoxic effect of UVB during plaque clearance in psoriasis is apoptosis of epidermal keratinocytes 10 . Furthermore, UVB damages nuclear DNA (a UVB's chromophore), which suppresses DNA synthesis in psoriatic epidermal cells 11 . In addition to its suppressive effect on keratinocytes, NB-UVB reduces the number of inflammatory myeloid dendritic cells (mDCs) and interleukin (IL)-17/22-producing CD3+ T cells 12 .…”

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confidence: 99%

Elucidating the NB-UVB mechanism by comparing transcriptome alteration on the edge and center of psoriatic plaques

Boonpethkaew

Meephansan

Charoensuksira

et al. 2023

Sci Rep

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Narrow band-ultraviolet B (NB-UVB) is an effective treatment for psoriasis. We aim to generate a potential mechanism of NB-UVB through comparing the transcriptomic profile before and after NB-UVB treatment between the peripheral edge of lesional skin (PE skin) and the center of lesional skin (CE skin) on the basis of molecular mechanisms of these two areas display different downstream functions. More than one-fourth of the NB-UVB-altered genes were found to be plaque-specific. Some of them were psoriasis signature genes that were downregulated by NB-UVB in, both, PE and CE skin (core alteration), such as IL36G, DEFB4A/B, S100A15, KRT16, and KRT6A. After NB-UVB treatment, the activity score of upstream cytokines, such as interferons, interleukin (IL)-6, IL-17, and IL-22 in pathogenesis decreased. In addition, NB-UVB could restore normal keratinization by upregulating LORICRIN and KRT2, particularly in the CE skin. Finally, we illustrated that NB-UVB is capable of suppressing molecules from the initiation to maintenance phase of plaque formation, thereby normalizing psoriatic plaques. This finding supports the usefulness of NB-UVB treatment in clinical practice and may help in the development of new treatment approaches in which NB-UVB treatment is included for patients with psoriasis or other inflammatory skin diseases.

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Phosphor for phototherapy: Review on psoriasis

Cited by 20 publications

References 39 publications

Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2

Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2

IL‐35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells

Elucidating the NB-UVB mechanism by comparing transcriptome alteration on the edge and center of psoriatic plaques

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