Phosphoranylation of Myo-Inositol : A New Route for a Simultaneous Synthesis of Several Myo-Inositol Phosphates

Bis(dimethylamino)phosphorodiamidate: A Reagent for the Regioselective Cyclophosphorylation of cis-Diols Enabling One-Step Access to High-Value Target Cyclophosphates

“…Because of its structural complexity, only a few (but unsuccessful) efforts have been made to explore the chemical-phosphorylation of unprotected inositol in one step. , Bruzik et al . and Vishwakarma and co-workers have demonstrated the enzymatic synthesis of various of O -alkyl inositol phosphates via inositol-1,2-cyclic phosphate (IcP) by using the PI-PLC enzyme.…”

“…11,43,45−47 Because of its structural complexity, only a few (but unsuccessful) efforts have been made to explore the chemical-phosphorylation of unprotected inositol in one step. 48,49 Bruzik et al 10 and Vishwakarma and co-workers 50 have demonstrated the enzymatic synthesis of various of Oalkyl inositol phosphates via inositol-1,2-cyclic phosphate (IcP) by using the PI-PLC enzyme. Because the enzymatic synthesis of inositol-1,2-cyclic phosphate involves the isolation of inositol phospholipids and PI-PLC from biological sources, which is not always straightforward, it is still a much soughtafter goal to chemically synthesize inositol-1,2-cyclic phosphate from unprotected inositol in a single step.…”