Phosphorescent Sensor for Biological Mobile Zinc

You, Youngmin; Lee, Sumin; Kim, Tae-Hee; Ohkubo, Kei; Chae, Weon‐Sik; Fukuzumi, Shunichi; Jhon, Gil‐Ja; Nam, Wonwoo; Lippard, Stephen J.

doi:10.1021/ja207163r

Cited by 226 publications

(134 citation statements)

References 151 publications

Supporting

Mentioning

132

Contrasting

Order By: Relevance

“…These complexes have also been utilized as external stimuli-responsive materials because of their highly sensitive photophysical properties to the microenvironment [21][22][23] . In addition, the long-lived phosphorescence of these complexes renders them suitable for a time-resolved luminescence technique, which is incompatible with short-lived fluorescent dyes 24,25 . In view of these interesting phosphorescence properties, in particular their high sensitivity to external stimuli and long phosphorescence lifetime, we believe that transition-metal complexes have a great potential to serve as materials for optical data recording and security protection.…”

mentioning

confidence: 99%

Smart responsive phosphorescent materials for data recording and security protection

et al. 2014

View full text Add to dashboard Cite

Smart luminescent materials that are responsive to external stimuli have received considerable interest. Here we report ionic iridium (III) complexes simultaneously exhibiting mechanochromic, vapochromic and electrochromic phosphorescence. These complexes share the same phosphorescent iridium (III) cation with a N-H moiety in the N^N ligand and contain different anions, including hexafluorophosphate, tetrafluoroborate, iodide, bromide and chloride. The anionic counterions cause a variation in the emission colours of the complexes from yellow to green by forming hydrogen bonds with the N-H proton. The electronic effect of the N-H moiety is sensitive towards mechanical grinding, solvent vapour and electric field, resulting in mechanochromic, vapochromic and electrochromic phosphorescence. On the basis of these findings, we construct a data-recording device and demonstrate data encryption and decryption via fluorescence lifetime imaging and time-gated luminescence imaging techniques. Our results suggest that rationally designed phosphorescent complexes may be promising candidates for advanced data recording and security protection. D ata recording, storage and security technologies have been widely utilized in economic and military fields as well as in our daily life. Smart luminescent materials that are responsive to external stimuli have received considerable attention in the construction of optical data recording and storage devices [1][2][3][4][5] . These materials have been classified on the basis of the types of external stimuli that they are responsive to. Mechanochromic materials show changes in emission colour in the presence of mechanical stimuli (for example, shearing, grinding and rubbing) because of the interruption of intermolecular interactions (for example, p-p stacking and hydrogen bonds) [6][7][8][9][10] . Vapochromic luminescence has been observed in materials that are responsive to volatile organic compounds 11,12 . Electric field is an important external stimulus. Electrochromism occurs in p-conjugated polymers because of the reversible transition between two redox states [13][14][15][16] . However, materials showing electrochromic luminescence, which is distinct luminescence colour responses to an electric field, are scarce. We envision the potential commercial applications of electrochromic luminescent materials because they can be conveniently integrated into semiconductor-based electronic devices. In addition, it is conceivable that compounds simultaneously showing mechanochromic, vapochromic and electrochromic luminescence are of great use to the development of multifunctional materials.Phosphorescent transition-metal complexes, such as those of Ir(III) and Pt(II), have been extensively studied for various photonic and electronic applications because of their rich excited-state properties, including high luminescence quantum yields, long emission lifetimes, large Stokes shifts, high photostability and various luminescence colours [17][18][19][20] . These complexes have also been utilized a...

show abstract

mentioning

confidence: 99%

Smart responsive phosphorescent materials for data recording and security protection

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Binding of Zn 2+ suppresses the nonradiative photoinduced electron-transfer (PeT) process from DPA to the excited cyclometalated iridium(III) polypyridine cores, leading to phosphorescence enhancement of these complexes. Similar Zn 2+ -induced phosphorescence response has also been observed in an intracellular environment using complexes 81 and 82 via confocal laser-scanning microscopy [62,63]. Another DPA-containing iridium(III) complex [Ir(ppy) 2 (btp-DPA)] (88) displays green and red dual phosphorescence because of limited internal conversion between two MLCT emissive states [64].…”

Section: Sensors For Ionsmentioning

confidence: 52%

“…[60]. A series of iridium(III) complexes 77-87 equipped with a 2,2 0 -dipicolylamine (DPA) unit has been designed as Zn 2+ sensors [61][62][63]. Binding of Zn 2+ suppresses the nonradiative photoinduced electron-transfer (PeT) process from DPA to the excited cyclometalated iridium(III) polypyridine cores, leading to phosphorescence enhancement of these complexes.…”

Section: Sensors For Ionsmentioning

confidence: 99%

“…For example, the iridium(III) DPA complexes 82 exhibit emission enhancement and lifetime elongation upon binding of Zn 2+ cations. The Zn 2+ sensing performance of these complexes has been evaluated in the presence of 10-methylacridinium (Acr + ) ion, which simulates typical autofluorescence [62]. The total emission of the mixture is enhanced by 1.7 fold upon addition of Zn 2+ .…”

Section: Lifetime-based Luminescence Microscopymentioning

confidence: 99%

See 1 more Smart Citation

Phosphorescent Iridium(III) Complexes for Bioimaging

Zhang

Liu

Zhao

et al. 2014

Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents

View full text Add to dashboard Cite

Phosphorescent iridium(III) complexes have received increasing attention in bioimaging applications owing to their advantageous photophysical properties and efficient internalization into live cells. In this chapter, we summarize the recent design of bioimaging reagents based on phosphorescent iridium(III) complexes. The utilizations of cationic, neutral, and zwitterionic phosphorescent iridium(III) complexes in bioimaging applications have been described first.Complexes showing aggregation-induced phosphorescence have also been included considering the absence of the commonly observed aggregation-caused quenching. Then we discuss the functionalization of iridium(III) complexes with biological substrates and reactive groups, which allows non-covalent and covalent interaction, respectively, with intracellular biomolecules. As the photophysical properties of iridium(III) complexes are very sensitive toward their surrounding ligands and microenvironment, the use of these complexes as intracellular sensors for gas molecules, ions, and amino acids has been summarized. Additionally, the incorporation of iridium(III) complexes into dendrimer, polymer, and nanoparticle systems providing attractive functionalities has been discussed. Furthermore, various strategies, including the use of near-infrared-emitting and two-photon excitable complexes, upconversion nanoparticles, and lifetime-based microscopy techniques, to enhance signal-to-noise ratios in bioimaging have been discussed. At last, the design of reagents for multi-mode imaging techniques involving phosphorescence and magnetic resonance imaging has been described.

show abstract

“…Due to the energy transfer from CPEs to metal complexes, OMCPEs exhibit narrow emission, which reduces the possibility of spectral overlap and thus potentially favors multiplex detection [22]. By taking advantages of the long lifetime of the metal complex, OMCPEs could also provide an effective means to reduce the background interference by using time-resolved photoluminescence technique (TRPT) [23]. Moreover, the energy transfer between the triplet state of the metal complex and the ground state of molecular oxygen could be triggered by photo-excitation, which generates singlet oxygen ( 1 O 2 ) and allows its potential application in photodynamic therapy (PDT) [24].…”

Section: Introductionmentioning

confidence: 99%

Organometallic Conjugated Polyelectrolytes: Synthesis and Applications

Cai

Zhan

Feng

et al. 2014

J Inorg Organomet Polym

View full text Add to dashboard Cite

Conjugated polyelectrolytes (CPEs) have gain great research interest during the past decades. The incorporation of phosphorescent transition-metal complexes into CPEs backbones could yield organometallic CPEs (OMCPEs), which exhibit unique physical and chemical properties, enabling their applications in electroluminescence device, sensing, bioimaging and photodynamic therapy fields. This review begins with a brief introduction of synthetic approaches towards OMCPEs, followed by summary of the recent advances for applications. Some outlooks are also highlighted at the end.

show abstract

Phosphorescent Sensor for Biological Mobile Zinc

Cited by 226 publications

References 151 publications

Smart responsive phosphorescent materials for data recording and security protection

Smart responsive phosphorescent materials for data recording and security protection

Phosphorescent Iridium(III) Complexes for Bioimaging

Organometallic Conjugated Polyelectrolytes: Synthesis and Applications

Contact Info

Product

Resources

About