Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters

Zhan, Mengsi; Wang, Dayuan; Zhao, Lingzhou; Chen, Liang; Ouyang, Zhijun; Mignani, Serge; Majoral, Jean-Pierre; Zhao, Jinhua; Zhang, Guixiang; Shi, Xiangyang; Shen, Mingwu

doi:10.1039/d3bm01198d

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…This could be ascribed to the highly rigid dendritic structure of phosphorus dendrimers, which is opposed to that of PAMAM dendrimers. Furthermore, we have also shown that core–shell tecto dendrimers with phosphorus dendrimers as a core display much higher gene delivery efficiency and amplified enhanced permeability and retention effect for improved tumor penetration and retention, which are desired for cancer therapy applications. All of these merits are attributable to the highly rigid structure of phosphorus dendrimers, which stimulates our further efforts to develop nonviral dendritic polymers with the simple molecular backbone for improved gene delivery to effectively tackle cancer.…”

Section: Introductionmentioning

confidence: 99%

Unsymmetrical Low-Generation Cationic Phosphorus Dendrimers as a Nonviral Vector to Deliver MicroRNA for Breast Cancer Therapy

Zou,

Shen,

Karpus

et al. 2024

Biomacromolecules

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The development of nonviral dendritic polymers with a simple molecular backbone and great gene delivery efficiency to effectively tackle cancer remains a great challenge. Phosphorus dendrimers or dendrons are promising vectors due to their structural uniformity, rigid molecular backbones, and tunable surface functionalities. Here, we report the development of a new lowgeneration unsymmetrical cationic phosphorus dendrimer bearing 5 pyrrolidinium groups and one amino group as a nonviral gene delivery vector. The created AB 5 -type dendrimers with simple molecular backbone can compress microRNA-30d (miR-30d) to form polyplexes with desired hydrodynamic sizes and surface potentials and can effectively transfect miR-30d to cancer cells to suppress the glycolysis-associated SLC2A1 and HK1 expression, thus significantly inhibiting the migration and invasion of a murine breast cancer cell line in vitro and the corresponding subcutaneous tumor mouse model in vivo. Such unsymmetrical low-generation phosphorus dendrimers may be extended to deliver other genetic materials to tackle other diseases.

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Section: Introductionmentioning

confidence: 99%

Unsymmetrical Low-Generation Cationic Phosphorus Dendrimers as a Nonviral Vector to Deliver MicroRNA for Breast Cancer Therapy

Zou,

Shen,

Karpus

et al. 2024

Biomacromolecules

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Structural and Property Characterizations of Dual‐Responsive Core–Shell Tecto Dendrimers for Tumor Penetration and Gene Delivery Applications

Liu,

Wang,

et al. 2024

Macromol. Rapid Commun.

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Core‐shell tecto dendrimers (CSTDs) with excellent physicochemical properties and good tumor penetration and gene transfection efficiency have been demonstrated to have the potential to replace high‐generation dendrimers in biomedical applications. However, their characterization and related biological properties of CSTDs for enhanced tumor penetration and gene delivery still lack in‐depth investigation. Herein, we attempted to design three types of dual‐responsive CSTDs for thorough physicochemical characterization and investigation of their tumor penetration and gene delivery efficiency. Three types of CSTDs were prepared through phenylborate ester bonds of phenylboronic acid (PBA)‐decorated generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers as cores and monose (galactose, glucose or mannose)‐conjugated G3 PAMAM dendrimers as shells and thoroughly characterized via NMR and other techniques. We show that the produced CSTDs displayed strong correlation signals between the PBA and monose protons and similar hydrodynamic diameters, and possess dual reactive oxygen species‐ and pH‐responsivenesses. The dual‐responsive CSTDs were proven to have structure‐dependent tumor penetration property and gene delivery efficiency in terms of small interference RNA for gene silencing and plasmid DNA for gene editing, thus revealing a great potential for different biomedical applications.This article is protected by copyright. All rights reserved

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Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters

Abstract: Nanoplatforms with amplified passive tumor targeting and enhanced protein resistance can evade unnecessary uptake by the reticuloendothelial system and achieve high tumor retention for accurate tumor theranostics. To achieve this...

Cited by 2 publications

References 39 publications

Unsymmetrical Low-Generation Cationic Phosphorus Dendrimers as a Nonviral Vector to Deliver MicroRNA for Breast Cancer Therapy

Unsymmetrical Low-Generation Cationic Phosphorus Dendrimers as a Nonviral Vector to Deliver MicroRNA for Breast Cancer Therapy

Structural and Property Characterizations of Dual‐Responsive Core–Shell Tecto Dendrimers for Tumor Penetration and Gene Delivery Applications

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