Phosphorus Dendrimers as Nanotools against Cancers

Caminade, Anne‐Marie

doi:10.3390/molecules25153333

Cited by 30 publications

(27 citation statements)

References 112 publications

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“…For the synthesis of dendritic polymers, anionic [ 31 , 32 , 33 , 34 ], click-chemistry [ 35 ] and organometal-catalyzed [ 36 ] techniques have already been employed and are reported in the literature. Due to their distinctive structures, dendritic polymers and/or dendrimers exhibit unique properties, rendering them suitable to be widely used in various applications [ 37 , 38 ], such as: drug delivery [ 39 , 40 , 41 , 42 ], catalytic systems [ 43 , 44 ], membranes [ 45 ], bioimaging [ 46 , 47 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Dendrons and Dendritic Terpolymers: Synthesis, Characterization and Self-Assembly Comparison

et al. 2020

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To the best of our knowledge, this is the very first time that a thorough study of the synthetic procedures, molecular and thermal characterization, followed by structure/properties relationship for symmetric and non-symmetric second generation (2-G) dendritic terpolymers is reported. Actually, the synthesis of the non-symmetric materials is reported for the first time in the literature. Anionic polymerization enables the synthesis of well-defined polymers that, despite the architecture complexity, absolute control over the average molecular weight, as well as block composition, is achieved. The dendritic type macromolecular architecture affects the microphase separation, because different morphologies are obtained, which do not exhibit long range order, and various defects or dislocations are evident attributed to the increased number of junction points of the final material despite the satisfactory thermal annealing at temperatures above the highest glass transition temperature of all blocks. For comparison reasons, the initial dendrons (miktoarm star terpolymer precursors) which are connected to each other in order to synthesize the final dendritic terpolymers are characterized in solution and in bulk and their self-assembly is also studied. A major conclusion is that specific structures are adopted which depend on the type of the core connection between the ligand and the active sites of the dendrons.

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Section: Introductionmentioning

confidence: 99%

Dendrons and Dendritic Terpolymers: Synthesis, Characterization and Self-Assembly Comparison

et al. 2020

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“…26 To date, PPH dendrimers have been synthesized successfully with the generation up to 12, being the highest among all types of dendrimers. 27 In recent years, it has been proven to be feasible to modify different cyclic amines such as pyrrolidine, morpholine, methyl piperazine, and phenyl piperazine onto the phosphorous dendrimer surface 28 and incorporate different metal elements to form various kinds of nanoplatforms for enhanced drug 29 or gene delivery 30 toward cancer management. Several remarkable reviews by Majoral, Mignani, and Caminade et al have well described the synthesis strategy and biological applications of phosphorous dendrimers.…”

Section: Phosphorous Dendrimersmentioning

confidence: 99%

“…Several remarkable reviews by Majoral, Mignani, and Caminade et al have well described the synthesis strategy and biological applications of phosphorous dendrimers. 28,31,32 Among various modified phosphorous dendrimers that have been reported, aza-bisphosphonate (ABP)-capped phosphorous dendrimers have been a focus for their interesting self-owned bioactivities involving the immune cells. Pioneering research shows that ABP-capped dendrimers impact the state of monocytes and exert anti-inflammatory effects via inducing the expression of mannose receptor 1 and anti-inflammatory cytokines (IL-4, IL-10 and IL-13) while decreasing the expression of inflammatory markers of CD64 and CD13.…”

Section: Phosphorous Dendrimersmentioning

confidence: 99%

“…Recently, the immunomodulatory effects of ABP-capped dendrimers have been well explored in vivo, especially in the treatment of rheumatoid arthritis, acute lung inflammation, neuron inflammation, and other inflammationrelated diseases. 28 For instance, Poupot et al 38 revealed the structure-dependent anti-inflammatory mechanism of ABP-capped dendrimers in a mouse arthritis model. Through analyzing the biological results with atomistic simulations, the dendrimers with 10 or 12 ABP terminal groups were found to be optimal in terms of bioactivity stimulation.…”

Section: Phosphorous Dendrimersmentioning

confidence: 99%

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Interaction of dendrimers with the immune system: An insight into cancer nanotheranostics

Gao

Shen

Shi

2021

VIEW

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The immune system is a network of defense mechanisms, made up of organs, tissues, and diversified immune cells, with the mission of detecting and attacking invading pathogens. Cancer immunotherapy, which triggers effective anticancer responses via the regulation or alteration of the immune system, has emerged as one novel powerful strategy to fight cancer in contrast to the conventional resorts including surgery, radiotherapy, and chemotherapy. With the recent rapid development of nanomedicine, more opportunities are afforded to achieve highly efficient cancer immunotherapy. Dendrimers present a category of nano-sized macromolecules with highly-branched three-dimensional structure, favorable biocompatibility, and tunable surface functionality. Various kinds of functionalized dendrimers and dendrimer-based nanohybrids have been explored in the treatment and diagnosis of cancer, and they have recently been proven to be promising in cancer immunotherapy. Herein we concisely review the interesting immunomodulatory effects of dendrimers, in particular the recent advances in dendrimer-facilitated cancer immunotherapy and cancer immunity visualization, and clarify the possible future perspectives for the design of dendrimerbased cancer immunotheranostics.

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“…Phosphorous and carbosilane dendrimers are inorganic dendrimers with interesting biomedical applications. These dendrimers demonstrate therapeutic effects against many cancer types and can be loaded with different anticancer drugs for drug delivery [ 67 , 68 ].…”

Section: Dendrimers For Breast Cancer Therapymentioning

confidence: 99%

The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

Alven

Aderibigbe

2020

Pharmaceutics

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Breast cancer is among the most common types of cancer in women and it is the cause of a high rate of mortality globally. The use of anticancer drugs is the standard treatment approach used for this type of cancer. However, most of these drugs are limited by multi-drug resistance, drug toxicity, poor drug bioavailability, low water solubility, poor pharmacokinetics, etc. To overcome multi-drug resistance, combinations of two or more anticancer drugs are used. However, the combination of two or more anticancer drugs produce toxic side effects. Micelles and dendrimers are promising drug delivery systems that can overcome the limitations associated with the currently used anticancer drugs. They have the capability to overcome drug resistance, reduce drug toxicity, improve the drug solubility and bioavailability. Different classes of anticancer drugs have been loaded into micelles and dendrimers, resulting in targeted drug delivery, sustained drug release mechanism, increased cellular uptake, reduced toxic side effects of the loaded drugs with enhanced anticancer activity in vitro and in vivo. This review article reports the biological outcomes of dendrimers and micelles loaded with different known anticancer agents on breast cancer in vitro and in vivo.

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Phosphorus Dendrimers as Nanotools against Cancers

Cited by 30 publications

References 112 publications

Dendrons and Dendritic Terpolymers: Synthesis, Characterization and Self-Assembly Comparison

Dendrons and Dendritic Terpolymers: Synthesis, Characterization and Self-Assembly Comparison

Interaction of dendrimers with the immune system: An insight into cancer nanotheranostics

The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

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