Phosphorus–nitrogen compounds Part 55. Syntheses of 4-methoxybenzylspiro(N/N)cyclotriphosphazenes: chemical, structural and biological properties

Phosphorus–nitrogen compounds: part 68. Synthesis, characterization, stereogenism, photophysical and bioactivity studies of novel unsymmetrical dispiro(N/N)cyclotriphosphazenes with carbazolyl and 4-chlorobenzyl pendant arms

“…It is clear that the endocyclic PN bonds are considerably shorter than the exocyclic PN bonds, consistent with the literature data. 25,26 In both phosphazenes, there are regular changes in endocyclic PN bond lengths in terms of the distances to P1: P1–N1 ≈ P3–N2 > P1–N3 ≈ P3–N3 > P2–N1 ≈ P2–N2, as observed in previous studies. 26,58…”

“…25,26 In both phosphazenes, there are regular changes in endocyclic PN bond lengths in terms of the distances to P1: P1–N1 ≈ P3–N2 > P1–N3 ≈ P3–N3 > P2–N1 ≈ P2–N2, as observed in previous studies. 26,58…”

“…The average coupling constant of 3 J PC1 for all compounds, except 8b , was calculated to be 6.6 Hz. As previously observed, 24–26 the 2 J PC value between the P-atom and NCH 2 spiro-carbons of unsymmetrical dispirophosphazenes containing 5-membered spiro-rings was determined to be much larger than that of 6-membered ones (Table S1, ESI†). On the other hand, some significant characteristic peaks appear in the 1 H NMR spectra of the dispirophosphazene derivatives.…”

“…It is possible to examine their chiralities by single crystal X-ray crystallography, circular dichroism (CD) and/or chiral solvating agent (CSA)-added 31 P NMR spectroscopy. 1,17,[24][25][26] Organocyclophosphazenes, polyorganophosphazenes and phosphazene dendrimers have a place in various fields such as technology, medicine and industry. Recently, various application areas of some new phosphazene derivatives have been explored.…”

Cyclo- and Polyphosphazenes for Biomedical Applications

“…The tetrapyrrolidino derivatives reported in Scheme 8 were found to inhibit the bacteria E. coli ATCC 25922, P. aeuroginosa , B. cereus , and P. vulgaris in a comparable extent as control antibiotics and demonstrated to be more active than Ketokonazole against C. albicans and C. tropicalis , exhibiting higher activity than the analogue PCl 2 -derivatives [ 112 , 113 ]. It has been demonstrated that the interaction of cyclophosphazenes with DNA caused a decrease in the mobility and intensities of form I and form II DNA due to the binding of the compounds with DNA to A/A and G/G nucleotides [ 114 , 115 , 116 ]. Similar compounds have been converted to protic salts, as reported in Figure 8 , for which an antiproliferative effect on tumor cell lines (A549, Hep 3B and FL) higher than both 5-fluorouracile and cisplatin was demonstrated, the most active being the compounds ( a ) and ( b ) [ 117 ].…”