Phosphorus-Sulfur Heterocycles Incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O Scaffold: One-Pot Synthesis and Crystal Structure Study

Hua, Guoxiong; Davidson, Karina W.; Cordes, David B.; Du, Junyi; Slawin, Alexandra M. Z.; Woollins, J. Derek

doi:10.3390/molecules22101687

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…Ion transport of calcium, iron, potassium, sodium, zinc, and selenium was enriched across both treatments and timepoints. In particular, transferrin, an iron transporter, was upregulated in the semen-inseminated samples at the D1 timepoint and has been shown to be associated with sperm storage in poultry (Matsuzaki et al, 2020;Kubota et al, 2023). In addition to nutrient availability, the local SST environment is also impacted by pH and reactive oxygen species (ROS).…”

Section: Discussionmentioning

confidence: 99%

Turkey hen sperm storage tubule transcriptome response to artificial insemination and the presence of semen

Brady,

Krasnec,

Hanlon

et al. 2024

Front. Physiol.

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Introduction: Sperm storage within the uterovaginal junction (UVJ) of avian species occurs in specialized structures termed sperm storage tubules (SSTs) and allows for prolonged storage of semen, though the molecular mechanisms involved in semen preservation are not well understood. Little work has been done examining how function of the SSTs is impacted by insemination and by semen present in the SSTs.Methods: Transcriptome analysis was performed on isolated SSTs from turkey hens receiving no insemination (control), sham-insemination, or semen-insemination at three timepoints (D1, D30, and D90 post-insemination). Bioinformatic and functional annotation analyses were performed using CLC Genomics Workbench, Database for Annotation, Visualization, and Integrated Discovery (DAVID), and Ingenuity Pathway Analysis (IPA). Pairwise comparisons and k-medoids cluster analysis were utilized to decipher differential expression profiles in the treatment groups.Results: The SST transcriptome of the semen inseminated group exhibited the greatest differences within the group, with differences detectable for up to 90 days post insemination, while control and sham-inseminated groups were more similar. In the semen-inseminated samples, upregulation of pathways relating to classical and non-classical reproductive signaling, cytoskeletal remodeling, physiological parameters of the local UVJ environment, and cellular metabolism was observed. In the sham-inseminated samples, upregulation of immune pathways and non-reproductive endocrine hormones was observed.Discussion: This work provides insights into the molecular level changes of the SST in response to insemination as well as to the presence of semen. Results from this study may have direct implications on fertility rates as well as potential strategies for avian semen cryopreservation protocols.

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Section: Discussionmentioning

confidence: 99%

Turkey hen sperm storage tubule transcriptome response to artificial insemination and the presence of semen

Brady,

Krasnec,

Hanlon

et al. 2024

Front. Physiol.

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“…These transversal competencies have become the basis for reference frameworks that provide guidance to learners and educators on how to improve their knowledge, skills and attitudes needed to live, work and behave in a manner caring for our planet (e.g., Bianchi et al, 2022). Yet, despite many initiatives to integrate ESD in higher education curricula (e.g., Behan et al, 2022), the extent to which such initiatives have been successful in transforming higher education is unclear, partially due to the lack of transparent measures for an objective assessment of ESD effectiveness, and partially due to the lack of clarity in universities on their role in driving the sustainability agenda (Sylvestre et al, 2014;Harvey et al, 2021). These factors are further complicated by the nebulous nature of sustainability, itself (Stough et al, 2018), and by differing expectations of sustainability outcomes in higher education (Palma and Pedrozo, 2015).…”

Section: Introductionmentioning

confidence: 99%

An evaluation of a computational technique for measuring the embeddedness of sustainability in the curriculum aligned to AASHE-STARS and the United Nations Sustainable Development Goals

et al. 2023

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IntroductionSDG 4.7 mandates university contributions to the United Nations (UN) Sustainable Development Goals (SDGs) through their education provisions. Hence, universities increasingly assess their curricular alignment to the SDGs. A common approach to the assessment is to identify keywords associated with specific SDGs and to analyze for their presence in the curriculum. An inherent challenge is associating the identified keywords as used in the diverse set of curricular contexts to relevant sustainability indicators; hence, the urgent need for more systematic assessment as SDG implementation passes its mid-cycle.MethodIn this study, a more nuanced technique was evaluated with notable capabilities for: (i) computing the importance of keywords based on the term frequency-inverse document frequency (TF-IDF) method; (ii) extending this computation to the importance of courses to each SDG and; (iii) correlating such importance to a statistical categorization based on the Association for the Advancement of Sustainability in Higher Education (AASHE) criteria. Application of the technique to analyze 5,773 modules in a university's curriculum portfolio facilitated categorization of the modules/courses to be “sustainability-focused” or “sustainability-inclusive.” With the strategic objective of systematically assessing the sustainability content of taught curricula, it is critical to evaluate the precision and accuracy of the computed results, in order to attribute text with the appropriate SDGs and level of sustainability embeddedness. This paper evaluates this technique, comparing its results against a manual and labor-intensive interpretation of expert informed assessment of sustainability embeddedness on a random sample of 306 modules/courses.Results and discussionExcept for SDGs 1 and 17, the technique exhibited a reasonable degree of accuracy in predicting module/course alignment to SDGs and in categorizing them using AASHE criteria. Whilst limited to curricular contexts from a single university, this study indicates that the technique can support curricular transformation by stimulating enhancement and reframing of module/course contexts through the lens of the SDGs.

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Preparation and Characterization of Phenyl Phosphine Diselenide – The Monomeric Form of Woollins' Reagent

2018

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We report the preparation, matrix‐isolation, and IR and UV/Vis spectroscopic characterization of phenyl phosphine diselenide, thus providing the first experimental evidence of the monomeric form of Woollins' reagent. Phenyl phosphine diselenide was prepared by thermal dissociation of Woollins' reagent and was identified by matching its spectroscopic data with density functional theory [B3LYP‐D3/6‐311++G(3df,3pd)] computations. The title compound proved to be highly photolabile and irradiation with light at λ = 334 nm results in the formation of hitherto unknown phenyldiselenyl phosphirane. Upon λ = 465 nm irradiation it rearranges back to phenyl phosphine diselenide.

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Phosphorus-Sulfur Heterocycles Incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O Scaffold: One-Pot Synthesis and Crystal Structure Study

Cited by 5 publications

References 34 publications

Turkey hen sperm storage tubule transcriptome response to artificial insemination and the presence of semen

Turkey hen sperm storage tubule transcriptome response to artificial insemination and the presence of semen

An evaluation of a computational technique for measuring the embeddedness of sustainability in the curriculum aligned to AASHE-STARS and the United Nations Sustainable Development Goals

Preparation and Characterization of Phenyl Phosphine Diselenide – The Monomeric Form of Woollins' Reagent

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