Phosphorylase a deficiency in pseudohypoparathyroidism

Hypocalcaemic myopathy with paranoid psychosis

“…Wolf and Lusk (1972) give a full account of such a case after subtotal thyroidectomy, and review the literature; in other reports, the association is not so clearly demonstrated. Cape (1969) described myopathy in a case of pseudohypoparathyroidism; histochemical examination showed a lack of phosphorylase activity in the muscle, and Cape suggested that there had been insufficient calcium to activate phosphoryl kinase. His patient had muscular weakness, and serum levels of CPK, LDH, and aldolase were markedly elevated; the serum calcium level was between 1.25 and 1.65 mmol/l (5.0-6.6 mg/dl).…”

Elevated muscle enzymes in a patient with severe hypocalcemia mimicking polymyositis

“…9 Hypocalcemia per se is considered to cause an elevation of serum CK. 1 Elevated levels of serum CK, along with hypocalcemia, were also observed in patients with pseudohypoparathyroidism, 10,11 and in a patient 12 and animals 13 with vitamin D deficiency. Several cases have been reported since 1972 concerning hypocalcemic myopathy or increased levels of serum CK in patients with idiopathic primary hypoparathyroidism.…”

New Aspects of Glycogen Metabolism

“…The demonstration of the b form of the enzyme, not a, probably reflects the larger proportion found in the b form in most muscles (796). The report that 2,4-dichlorophenoxyacetate is an inhibitor in histochemical demonstrations of phosphorylase may be useful in histochemical circles (791).…”