Phosphorylase Kinase

Rice, Nancy A.; Carlson, Gerald M.

doi:10.1002/0471203076.emm0981

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Human-engineered artificial atoms have great flexibility and controllability [3,[14][15][16][17]. Therefore there is much to be gained by using optimal control theory methods [18][19][20] to engineer the control pulses producing the gates.…”

Section: Introductionmentioning

confidence: 99%

Optimized controlled-Z gates for two superconducting qubits coupled through a resonator

Egger

Wilhelm

2013

Supercond. Sci. Technol.

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Superconducting qubits are a promising candidate for building a quantum computer. A continued challenge for fast yet accurate gates to minimize the effects of decoherence. Here we apply numerical methods to design fast entangling gates, specifically the controlled Z, in an architecture where two qubits are coupled via a resonator. We find that the gates can be sped up by a factor of two and reach any target fidelity. We also discuss how systematic errors arising from experimental conditions affect the pulses and how to remedy them, providing a strategy for the experimental implementation of our results. We discuss the shape of the pulses, their spectrum and symmetry.

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Section: Introductionmentioning

confidence: 99%

Optimized controlled-Z gates for two superconducting qubits coupled through a resonator

Egger

Wilhelm

2013

Supercond. Sci. Technol.

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“…In humans, glycogen storage diseases (GSDs) can result from a deficiency in any of the enzymes involved in either the synthesis or degradation of glycogen. GSD Type IX results from a deficiency in PhK, and there is significant heterogeneity in the disease as it can result from mutations in any of the seven genes that encode for PhK subunits [5]. In particular for this study, humans that have mutations in PHKA1, the gene encoding the muscle-specific variant of the α subunit, present with muscle weakness and rapid fatigue upon exercise [6,7], as well as muscle cramps and stiffness combined with exercise intolerance [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The <i>phka</i>1 deficient I/LnJ mouse exhibits endurance exercise deficiency with no compensatory changes in glycolytic gene expression

Mefford¹,

Ayers²,

Rowland³

et al. 2013

OJMIP

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During exercise, phosphorylase kinase (PhK) is the key regulatory enzyme responsible for maintaining glycogenolytic flux to sustain muscle contraction. The absence of PhK in skeletal muscle results in glycogen storage disease (GSD) Type IX which is characterized by muscle weakness and rapid fatigue upon exercise. In this study, we have used the phka1 deficient I/LnJ mouse model of GSD to investigate the physiological and genetic adaptations that occur in response to voluntary exercise. When quantified over training periods of either 1, 2, or 5 weeks, I/LnJ mice ran significantly less time/day and distance/day than agematched C57/Bl6 mice. Cumulatively after five weeks, adult I/LnJ mice ran ~1/2 the total time and distance of wild-type mice, 116 ± 6 hours and 211 ± 23 km versus 194 ± 3 hours and 418 ± 4 km, respectively. After 5 weeks, C57/Bl6 mice demonstrated an increase in endurance as a result of aerobic training; this observed physiological adaptation was not present in I/LnJ mice. The decrease in total distance run by I/LnJ mice was not due to a reduction in speed; juvenile and adult I/LnJ mice ran ~75%-80% as fast as C57/Bl6 mice. When transcription of glycolytic genes glucose transporter 4 (scla1), pyruvate dehydrogenase (pdha1), and phosphofructokinase (pfk) were quantified at the end of each training period, no significant differences in expression levels were found between mouse strains, suggesting that non-glycolytic mechanisms work to maintain the muscle function observed in the I/LnJ mice.

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Phosphorylase Kinase

Cited by 2 publications

References 19 publications

Optimized controlled-Z gates for two superconducting qubits coupled through a resonator

Optimized controlled-Z gates for two superconducting qubits coupled through a resonator

The <i>phka</i>1 deficient I/LnJ mouse exhibits endurance exercise deficiency with no compensatory changes in glycolytic gene expression

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Phosphorylase Kinase

Cited by 2 publications

References 19 publications

Optimized controlled-Z gates for two superconducting qubits coupled through a resonator

Optimized controlled-Z gates for two superconducting qubits coupled through a resonator

The &lt;i&gt;phka&lt;/i&gt;1 deficient I/LnJ mouse exhibits endurance exercise deficiency with no compensatory changes in glycolytic gene expression

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The <i>phka</i>1 deficient I/LnJ mouse exhibits endurance exercise deficiency with no compensatory changes in glycolytic gene expression