Phosphorylated Codonopsis pilosula polysaccharide could inhibit the virulence of duck hepatitis A virus compared with Codonopsis pilosula polysaccharide

Ke, Ming; Chen, Yun; Yao, Fangke; Shi, Jincheng; Yang, Jingjing; Du, Hongzhi; Wang, Xunyi; Wang, Yixuan; Liu, Jiaguo

doi:10.1016/j.ijbiomac.2016.10.002

Cited by 62 publications

(19 citation statements)

References 34 publications

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“…The new adsorption peak at 1293 cm −1 was ascribed to the stretching vibration of the P=O band. The peak at 1105 cm −1 originated from the stretching vibration of the C–O–P band [14,17]. The peak at 995 cm −1 was ascribed to the O–P–O band [36].…”

Section: Resultsmentioning

confidence: 99%

“…Among the modification methods, phosphorylation modification methods can be used to significantly enhance bioactivities [16], which comprise good antitumor, antioxidant, and antiviral activities [17]. In one study, a phosphorylated Codonopsis pilosula polysaccharide was synthesized and characterized, and its ability to inhibit the virulence of duck hepatitis A virus was compared with that of an unmodified Codonopsis pilosula polysaccharide [17]. In another study, a phosphorylated sago starch-extraction residue was prepared for the removal of cadmium from wastewater [14].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Application of Phosphorylated Xylan as a Flocculant for Cationic Ethyl Violet Dye

Xia

et al. 2018

Polymers

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Abstract:In this study, phosphorylated birchwood xylan was produced under alkali conditions using trisodium trimetaphosphate. Three single-factor experiments were used to explore the influences of time, temperature, and the molar ratio of trisodium trimetaphosphate to xylan on the degree of substitution (DS) and charge density of xylan. The response surface methodology was used to explore the interaction of these three factors. Phosphorylated xylan with a maximum DS of 0.79 and a charge density of −3.40 mmol/g was produced under the optimal conditions of 80 • C, 4 h, and a molar ratio of xylan/sodium trimetaphosphate (STMP) of 1/3. Fourier transform infrared (FTIR), ascorbic acid method analyses, and inductively coupled plasma-atomic emission spectrometer (ICP-AES) analyses confirmed that the phosphate groups were successfully attached to xylan. Thermogravimetric analysis confirmed that phosphorylated xylan was less stable than birchwood xylan. Furthermore, the phosphorylated xylan was applied as a flocculant for removing ethyl violet dye from a simulated dye solution. The results indicated that more than 95% of the dye was removed from the solution. The theoretical and experimental values of charge neutralization for the dye removal were close to one another, confirming that charge neutralization was the main mechanism for the interaction of dye and phosphorylated xylan. The impacts of salts on the flocculation efficiency of phosphorylated xylan were also analyzed.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and Application of Phosphorylated Xylan as a Flocculant for Cationic Ethyl Violet Dye

Xia

et al. 2018

Polymers

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“…After MDCK cells were infected by H1N1 and H3N2, the cytopathic effect (CPE) was calculated separately and the corresponding 50% tissue culture infective dose (TCID 50 ) was calculated according to the Reed-Muench method [12]. In this study, the TCID 50 of H1N1 was 10 −4.7 /100 µL, and the TCID 50 of H3N2 was 10 −4.7 /100 µL.…”

Section: Establishment Of Alveolar Macrophage Cell (3d4/21) Model Inf...mentioning

confidence: 86%

The Competitive Endogenous RNA (ceRNA) Regulation in Porcine Alveolar Macrophages (3D4/21) Infected by Swine Influenza Virus (H1N1 and H3N2)

Dai

Gao

Cheng

et al. 2022

IJMS

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H1N1 and H3N2 are the two most common subtypes of swine influenza virus (SIV). They not only endanger the pig industry, but are also a huge risk of zoonotic diseases. However, the molecular mechanism and regulatory network of pigs (hosts) against influenza virus infection are still unclear. In this study, porcine alveolar macrophage cell (3D4/21) models infected by swine influenza virus (H1N1 and H3N2) were constructed. The expression profiles of miRNAs, mRNAs, lncRNAs and circRNAs after H1N1 and H3N2 infected 3D4/21 cells were revealed in this study. Then, two ceRNAs (TCONS_00166432-miR10391-MAN2A1 and novel_circ_0004733-miR10391-MAN2A1) that regulated H1N1 and H3N2 infection in 3D4/21 cells were verified by the methods of bioinformatics analysis, gene overexpression, gene interference, real-time quantitative PCR (qPCR), dual luciferase activity assay and RNA immunoprecipitation (RIP). In addition, the important candidate molecules (miR-10391, TCONS_00166432, and novel_circ_0004733) were identified by qPCR and enzyme linked immunosorbent assay (ELISA). Finally, the regulatory effect and possible molecular mechanism of the target gene MAN2A1 were identified by the methods of gene interference, qPCR, Western blot and ELISA. The results of this study suggested that TCONS_00166432 and novel_circ_0004733 could competitively bind miR-10391 to target the MAN2A1 gene to regulate swine influenza virus infecting 3D4/21 cells. This study reported for the first time the ceRNA networks involved in the regulation of the swine influenza virus infecting 3D4/21 cells, which provided a new insight into the molecular mechanism of 3D4/21 cells against swine influenza virus infection.

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“…It was reported that RRRP could significantly reduce mortality rate, liver lesion scoring, alleviate visual liver lesion, and decrease the alterations of plasma biochemical evaluation indexes of hepatic injury induced by DHAV-1 infection [79]. pCPP was also reported to demonstrate a strong inhibitory effect on DHAV-1 replication, which led to a significant decrease on the number of viral particles [80]. Studies with DHAV-1-infected ducklings treated with BAPC showed that it significantly inhibited DHAV-1 adsorption, replication and release [81].…”

Section: Miscellaneous Productsmentioning

confidence: 99%

Antiviral Natural Products against Hepatitis-A Virus

Odimegwu¹,

Ukachukwu²

2020

Hepatitis a and Other Associated Hepatobiliary Diseases

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The review on antiviral anti-hepatitis A virus agents is warranted given the importance of hepatitis A virus (HAV) as a human pathogen. Novel antiviral drugs have been sourced from natural agents and developed into products for management of viral infections. The role of purified natural products in treatment and as adjunctives in the management of HAV infections is clearly plausible. Treatments against Hepatitis A virus infection is currently limited. In this chapter, the antiviral natural products against hepatitis-A virus (HAV), their sources as well as their treatment approach and their application have been discussed. The antiviral natural products could be sourced generally from plants, herbs and animals. These natural agents have been shown to demonstrate substantial antiviral activity against HAV and could target various stages of the viral life cycle, replication, assemblage, release, as well as targeting virus-host specific interactions.

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Phosphorylated Codonopsis pilosula polysaccharide could inhibit the virulence of duck hepatitis A virus compared with Codonopsis pilosula polysaccharide

Cited by 62 publications

References 34 publications

Preparation and Application of Phosphorylated Xylan as a Flocculant for Cationic Ethyl Violet Dye

Preparation and Application of Phosphorylated Xylan as a Flocculant for Cationic Ethyl Violet Dye

The Competitive Endogenous RNA (ceRNA) Regulation in Porcine Alveolar Macrophages (3D4/21) Infected by Swine Influenza Virus (H1N1 and H3N2)

Antiviral Natural Products against Hepatitis-A Virus

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