Phosphorylated PAMAM dendrimers: an analog of dentin non-collagenous proteins, enhancing the osteo/odontogenic differentiation of dental pulp stem cells

Liu, Jie; Gao, Yuan; Zhu, Xiaodong; Zhang, Yuerong; Xu, Hai; Wang, Tianda; Zhang, Guangdong

doi:10.1007/s00784-021-04149-3

Cited by 6 publications

(7 citation statements)

References 56 publications

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“…Only in one study [15] was item 8* considered valid, as it reflected which authors had carried out each part of the study, some having developed the method and others having analyzed the results. Similarly, item 4 was not met by a number of studies [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] because it could only be awarded if it expressly stated "measure of outcomes".…”

Section: Quality Evaluation Resultsmentioning

confidence: 99%

“…The secondmost prevalent year is 2022, with three publications; however, no studies were published in 2020 or 2023. Given that the effect of nanoparticles is a technology-related topic and is On the other hand, items 3, 11, and 13, referring to the structuring of the article, results and estimation, and funding, respectively, were respected by a number of articles [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Item 1, based on the structuring of the initial abstract, was not fulfilled by many articles [11,12,[14][15][16]20,22,25,26].…”

Section: Bibliometric Analysismentioning

confidence: 99%

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Use of Nanoparticles in Regenerative Dentistry: A Systematic Review

Pecci-Lloret,

Gea-Alcocer,

Murcia-Flores

et al. 2024

Biomimetics

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Introduction: nanoparticles are tiny-sized materials whose characteristics and properties mean that their association with dental materials is being investigated to ascertain their effects and possible benefits on tooth structures. This systematic review aimed to qualitatively collect in vitro studies that address the potential application of different nanoparticles in dental regeneration. Following an exhaustive search and article selection process, 16 in vitro studies that met our eligibility criteria were included. BG-NPs were analyzed across five studies, with three demonstrating their impact on the growth and differentiation of human hDPSCs. CS-NPs were examined in three studies, with findings from two indicating a significant effect on the differentiation of SCAPs. Nanoparticles’ therapeutic potential and their stimulatory effect on promoting the regeneration of cells of the dentin-pulp complex have been proven. Their effect is altered according to the type of nanoparticle, concentration, and substances associated with them and, depending on these variables, they will affect the pulp, dentine, and dental cementum differently.

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Section: Quality Evaluation Resultsmentioning

confidence: 99%

Section: Bibliometric Analysismentioning

confidence: 99%

Use of Nanoparticles in Regenerative Dentistry: A Systematic Review

Pecci-Lloret,

Gea-Alcocer,

Murcia-Flores

et al. 2024

Biomimetics

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“…On top of that, they modulated their differentiation toward the improvement of their odontogenic properties [ 207 ]. PAMAM derivatives phosphorylated via the Mannich-type reaction ( Figure 19 ) may also mediate odontogenic differentiation of the dental pulp stem cells and assist their proliferation [ 208 ].…”

Section: Applications Of Dendritic Polymers In Dentistrymentioning

confidence: 99%

“… Synthesized mechanism of PAMAM-PO 3 H 2 via the Mannich-type reaction Reproduced under permission from [ 208 ]. Copyright: The Author(s).…”

Section: Figurementioning

confidence: 99%

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

et al. 2023

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The capability of radially polymerized bio-dendrimers and hyperbranched polymers for medical applications is well established. Perhaps the most important implementations are those that involve interactions with the regenerative mechanisms of cells. In general, they are non-toxic or exhibit very low toxicity. Thus, they allow unhindered and, in many cases, faster cell proliferation, a property that renders them ideal materials for tissue engineering scaffolds. Their resemblance to proteins permits the synthesis of derivatives that mimic collagen and elastin or are capable of biomimetic hydroxy apatite production. Due to their distinctive architecture (core, internal branches, terminal groups), dendritic polymers may play many roles. The internal cavities may host cell differentiation genes and antimicrobial protection drugs. Suitable terminal groups may modify the surface chemistry of cells and modulate the external membrane charge promoting cell adhesion and tissue assembly. They may also induce polymer cross-linking for healing implementation in the eyes, skin, and internal organ wounds. The review highlights all the different categories of hard and soft tissues that may be remediated with their contribution. The reader will also be exposed to the incorporation of methods for establishment of biomaterials, functionalization strategies, and the synthetic paths for organizing assemblies from biocompatible building blocks and natural metabolites.

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“…On top of that, they modulated their differentiation toward the improvement of their odontogenic properties [185]. PAMAM derivatives phosphorylated via the Mannichtype reaction (Figure 19) may also mediate odontogenic differentiation of the dental pulp stem cells and assist their proliferation [186].…”

Section: Interactions With Odontoblasts and Dental Pulp Cellsmentioning

confidence: 99%

Dendritic Polymers Applications in Tissue Engineering

Arkas¹,

Vardavoulias²,

Kythreoti³

et al. 2022

Preprint

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The capability of radially polymerized bio-dendrimers and hyperbranched polymers for medical applications is well established. Among them, perhaps the most important are those that involve interactions with the regenerative mechanisms of cells. Dendritic polymers due to their distinctive architecture may play a multitude of roles such as protein biomimicry (collagen, elastin, hydroxy apatite production), gene and drug delivery (cell differentiation, antimicrobial protection), surface chemistry and charge modulation (adhesion to cells and tissues), polymer cross-linking (eye, skin and internal organ wound healing). The review highlights all the different categories of hard and soft tissues that may be remediated with their contribution. The reader will be also exposed to the incorporation methods to established biomaterials such as scaffolds, the functionalization strategies, and the synthetic paths for the assembly from biocompatible building blocks and natural metabolites.

show abstract

Phosphorylated PAMAM dendrimers: an analog of dentin non-collagenous proteins, enhancing the osteo/odontogenic differentiation of dental pulp stem cells

Cited by 6 publications

References 56 publications

Use of Nanoparticles in Regenerative Dentistry: A Systematic Review

Use of Nanoparticles in Regenerative Dentistry: A Systematic Review

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

Dendritic Polymers Applications in Tissue Engineering

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