Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Tang, Yong; Luo, Keyu; Chen, Yin; Chen, Yueqi; Zhou, Rui; Chen, Can; Tan, Jiulin; Deng, Min‐Zhi; Dai, Qijie; Yu, Xueke; Liu, Jian; Zhang, Chengmin; Wu, Wenjie; Xu, Jianzhong; Dong, Shiwu; Luo, Fei

doi:10.1016/j.bioactmat.2020.12.025

Cited by 11 publications

(10 citation statements)

References 62 publications

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“…In addition, the positive effect of NID1 on bone regeneration may be attributed to angiogenesis in situ. The results of these in vivo experiments verified the effectiveness of EV-NID1, further confirmed the theory of angiogenesis-osteogenesis coupling [ [59] , [60] , [61] ], and provided new targets and perspectives for future clinical vascularization strategies.…”

Section: Discussionsupporting

confidence: 68%

Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion

Cheng

Cao

Zhao

et al. 2022

Bioactive Materials

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Section: Discussionsupporting

confidence: 68%

Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion

Cheng

Cao

Zhao

et al. 2022

Bioactive Materials

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“…It has been suggested that the phosphorylation state of PTP1B tyrosine-152 (Y152) plays a central role in initiating the departure of MSCs and ECs from their niches and their subsequent recruitment to bone defects. In fact, the peptide 152RM (PTP1B Y152 region-mimicking peptide) loaded onto DMB scaffolds with mesoporous silica nanoparticles (MSNs) [ 78 ] significantly inhibited the phosphorylation of PTP1B Y152 [ 79 ], enhanced MSCs migration and osteogenic differentiation. Moreover, in vivo studies showed that this scaffold coupled the osteogenesis and angiogenesis processes, by inducing bone formation and the expansion of a certain type of blood vessels adjacent to the growth plate, closely related to the speed of bone healing [ 80 ].…”

Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.

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“…Additionally, blood flow in type H vessels regulates Notch signaling; a low rate suppresses the pathway, leading to defective osteogenesis and angiogenesis ( Ramasamy et al, 2016 ). On the other hand, there is evidence that activation of Notch signaling could induce the formation of type H vessels ( Tang et al, 2021 ). Liao et al (2017) investigated the angiogenesis-osteogenesis coupling in MSCs in response to dual stimulation with BMP-9 and Notch signaling.…”

Section: Importance Of Angiogenesis In Bone Development and Repairmentioning

confidence: 99%

Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis

Yang²,

Liu³

et al. 2023

Front. Pharmacol.

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Bone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including bone tumors, trauma, and extensive fractures, where the self-healing property of bone cannot repair the defect. Bone tissue engineering is composed of three main elements: progenitor/stem cells, scaffold, and growth factors/biochemical cues. Among the various biomaterial scaffolds, hydrogels are broadly used in bone tissue engineering owing to their biocompatibility, controllable mechanical characteristics, osteoconductive, and osteoinductive properties. During bone tissue engineering, angiogenesis plays a central role in the failure or success of bone reconstruction via discarding wastes and providing oxygen, minerals, nutrients, and growth factors to the injured microenvironment. This review presents an overview of bone tissue engineering and its requirements, hydrogel structure and characterization, the applications of hydrogels in bone regeneration, and the promising roles of hydrogels in bone angiogenesis during bone tissue engineering.

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Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Cited by 11 publications

References 62 publications

Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion

Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis

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