Phosphorylation of histone H3 in plants—A dynamic affair

Houben, Andreas; Demidov, Dmitri; Caperta, Ana D.; Karimi, Raheleh; Agueci, Francesco; Vlasenko, Liudmila

doi:10.1016/j.bbaexp.2007.01.002

Cited by 125 publications

(130 citation statements)

References 85 publications

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“…An increase in phosphorylation of histone H3 at serine 10 (H3S10ph) occurs from early prophase until telophase, a feature common to plants and animals (Hendzel et al, 1997;Cobb et al, 1999;Houben et al, 1999). Phosphorylation of other residues of H3, typically, T3, T11 and S28, also occurs during mitosis and meiosis (Houben et al, 2007). Multiple kinases have been identified in mammalian cells that show H3 phosphorylation activity (Ito, 2007).…”

Section: B Desvoyes Et Almentioning

confidence: 99%

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

et al. 2010

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Eukaryotic chromatin is a highly structured macromolecular complex of which DNA is wrapped around a histone-containing core. DNA can be methylated at specific C residues and each histone molecule can be covalently modified at a large variety of amino acids in both their tail and core domains. Furthermore, nucleosomes are not static entities and both their position and histone composition can also vary. As a consequence, chromatin behaves as a highly dynamic cellular component with a large combinatorial complexity beyond DNA sequence that conforms the epigenetic landscape. This has key consequences on various developmental processes such as root and flower development, gametophyte and embryo formation and response to the environment, among others. Recent evidence indicate that posttranslational modifications of histones also affect cell cycle progression and processes depending on a correct balance of proliferating cell populations, which in the context of a developing organisms includes cell cycle, stem cell dynamics and the exit from the cell cycle to endoreplication and cell differentiation. The impact of epigenetic modifications on these processes will be reviewed here.

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Section: B Desvoyes Et Almentioning

confidence: 99%

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

et al. 2010

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“…In addition, H4S1 phosphorylation seems to have an evolutionarily conserved role in chromatin compaction during the later stages of gametogenesis (1,19). Thus, phosphorylation of specific histone residues appears to function in a number of chromosomal transactions (1,(8)(9)(10), but its potential role in epigenetic gene silencing remains uncertain. Interestingly, we have now identified a Chlamydomonas mutant, disrupted in the gene encoding a histone kinase that is defective in heritable gene silencing.…”

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confidence: 99%

“…Phosphorylation of a number of Ser or Thr histone residues has been implicated in gene activation as well as in cell cycledependent chromosome condensation, DNA repair, and apoptosis-induced chromatin compaction (1,(8)(9)(10). In several plant species, similarly to metazoans, histone H3 is hyperphosphorylated at Ser-10/28 during mitosis and meiosis, and these modifications appear to be required for proper chromosome segregation and cell cycle progression (9,10,11).…”

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confidence: 99%

“…In several plant species, similarly to metazoans, histone H3 is hyperphosphorylated at Ser-10/28 during mitosis and meiosis, and these modifications appear to be required for proper chromosome segregation and cell cycle progression (9,10,11). H3S10 phosphorylation (H3S10ph) is also involved in the transcriptional activation of genes responding to stress or mitogenstimulated signaling pathways in animals (10,12), and it has been found to increase transiently in plant cells subject to abiotic stresses (9,13). Indeed, H3S10ph facilitates RNA polymerase II release from promoter-proximal pausing in Drosophila (12) and binding of heterochromatin protein 1 (HP1), a polypeptide involved in heterochromatin formation, to H3K9me3 is disrupted by the presence of a phosphate group on Ser-10 (14, 15).…”

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The MUT9p kinase phosphorylates histone H3 threonine 3 and is necessary for heritable epigenetic silencing in Chlamydomonas

Casas-Mollano¹,

Jeong²,

Xu³

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

101

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“…Phosphorylation of histone H3 on Thr3 was also examined in plants. In most of the species studied, it appears on chromosomes at the end of G2 phase and disappears during anaphase [27], in contrast to mammals, phosphorylation of Thr3 is seen primarily at pericentromeres in prophase and then along chromosome arms during prometaphase [27,28].…”

Section: Haspin Localizationmentioning

confidence: 98%

The Mitotic Protein Kinase Haspin and Its Inhibitors

Feizbakhsh¹,

Place²,

Fant³

et al. 2017

Protein Phosphorylation

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Haspin is an atypical serine/threonine protein kinase essential to mitosis. Unlike other protein kinases, its kinase domain does not require phosphorylation in order to be activated and bears very high substrate specificity and selectivity. Few substrates have been identified so far. Haspin phosphorylation on threonine 3 of Histone H3 from prophase to anaphase participates to centromeric Aurora B localization and ensures proper kinetochore-microtubule attachment. Haspin is also involved in the maintenance of centromeric cohesion and the mitotic spindle. Inhibitors have been developed and provided tools to dissect Haspin function. The kinase is now considered as a potential therapeutic target against cancer. We discuss here the latest findings on this essential mitotic protein.

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Phosphorylation of histone H3 in plants—A dynamic affair

Cited by 125 publications

References 85 publications

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

The MUT9p kinase phosphorylates histone H3 threonine 3 and is necessary for heritable epigenetic silencing in Chlamydomonas

The Mitotic Protein Kinase Haspin and Its Inhibitors

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