2019
DOI: 10.15252/emmm.201910880
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Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis

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Cited by 58 publications
(65 citation statements)
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“…Identifying novel mechanisms underlying the maintenance of the stemness of CSCs is one of the most important work for developing novel therapeutic strategies [25]. Although it was previously reported that SCF complexes plays a crucial role in cancer development, few was known about its role in CSCs [26]. In this study, we found that overexpression of SKP1 promotes the stemness of CRC-SCs and knockdown of SKP1 leads to the opposite results.…”
Section: Discussionmentioning
confidence: 67%
“…Identifying novel mechanisms underlying the maintenance of the stemness of CSCs is one of the most important work for developing novel therapeutic strategies [25]. Although it was previously reported that SCF complexes plays a crucial role in cancer development, few was known about its role in CSCs [26]. In this study, we found that overexpression of SKP1 promotes the stemness of CRC-SCs and knockdown of SKP1 leads to the opposite results.…”
Section: Discussionmentioning
confidence: 67%
“…Activation of the CDK1-TFCP2L1 pathway stimulated cell proliferation, self-renewal and invasion in human aggressive bladder cancer. 31 Deng 32 reported that the up-regulation of CDK1 inhibited the G2/M phase block and promoted cervical cancer resistance to radiotherapy. CDK1 was also found to be stably activated by CDK1-KCTD12 interaction in BRAF-mutated colon cancer models resistant to Vemurafenib.…”
Section: Discussionmentioning
confidence: 99%
“…All M-MSCs were expanded for less than ten passages to ensure multipotency. To induce stable GFP expression, M-MSCs were infected with a GFP-expressing lentivirus, which was generated as described previously [ 28 , 29 ]. M-MSCs were infected with concentrated lentivirus containing a GFP expression construct using 6 µg/mL polybrene (Invitrogen, Carlsbad, CA, USA), and infected cells were selected using 6 µg/mL blasticidin (Invitrogen).…”
Section: Methodsmentioning
confidence: 99%