Phosphorylation of the Antiviral Protein Interferon-inducible Transmembrane Protein 3 (IFITM3) Dually Regulates Its Endocytosis and Ubiquitination

Chesarino, Nicholas M.; McMichael, Temet M.; Hach, Jocelyn C.; Yount, Jacob S.

doi:10.1074/jbc.m114.557694

Cited by 126 publications

(197 citation statements)

References 33 publications

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“…Recent work in vitro suggests that although this alteration of IFITM3 decreases antiviral activity against influenza virus, its activity against retroviruses is increased (29), thus revealing a potential selective advantage for the SNP that may explain its high prevalence in certain human populations (177). Additionally, given that IFITM3 antiviral activity is highly regulated by at least four posttranslational modifications, polymorphisms in factors that install or remove these modifications and impact influenza virus susceptibility may be uncovered in the future (22–24, 117, 172). …”

Section: Influenza Virusmentioning

confidence: 99%

Human Genetic Determinants of Viral Diseases

et al. 2017

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Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases. Herein we review multiple discoveries made with genome-wide or candidate gene approaches that have revealed significant insights into virus–host interactions. Genetic factors that have been identified include genes encoding virus receptors, receptor-modifying enzymes, and a wide variety of innate and adaptive immunity-related proteins. We discuss a range of pathogenic viruses, including influenza virus, respiratory syncytial virus, human immunodeficiency virus, human T cell leukemia virus, human papilloma virus, hepatitis B and C viruses, herpes simplex virus, norovirus, rotavirus, parvovirus, and Epstein-Barr virus. Understanding the genetic underpinnings that affect infectious disease outcomes should allow tailored treatment and prevention approaches in the future.

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Section: Influenza Virusmentioning

confidence: 99%

Human Genetic Determinants of Viral Diseases

et al. 2017

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“…We and others have found that the small membrane-associated interferon-inducible transmembrane proteins (IFITMs) can inhibit the replication of a wide range of pathogenic viruses, including all flaviviruses tested to date, including West Nile virus, dengue virus, and reporter viruses carrying the envelope of the Omsk hemmorhagic fever virus (Bailey et al, 2014;Brass et al, 2009;Chesarino et al, 2014aChesarino et al, , 2014bChesarino et al, , 2015Everitt et al, 2012;Huang et al, 2011;Perreira et al, 2013;Tartour et al, 2014). Murine models of Zika virus pathogenesis require an absence of type I interferon (IFN) signaling, suggesting that IFN-stimulated genes (ISGs) can prevent heightened levels of infection .…”

Section: Introductionmentioning

confidence: 99%

The IFITMs Inhibit Zika Virus Replication

et al. 2016

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Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. Moreover, IFITM3 can prevent Zika-virus-induced cell death. These results suggest that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.

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“…Interestingly, 41 of the 199 druggable cellular factors were shown to be implicated in IAV infection (Table S2) [10,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,...…”

Section: Combination Of Various Omics Techniques Identifies Potentmentioning

confidence: 99%

Multi-Omics Studies towards Novel Modulators of Influenza A Virus–Host Interaction

Söderholm

Gaelings

et al. 2016

Viruses

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Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV–host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV–host interactions, which might be more effective than the currently available anti-influenza therapeutics.

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Phosphorylation of the Antiviral Protein Interferon-inducible Transmembrane Protein 3 (IFITM3) Dually Regulates Its Endocytosis and Ubiquitination

Cited by 126 publications

References 33 publications

Human Genetic Determinants of Viral Diseases

Human Genetic Determinants of Viral Diseases

The IFITMs Inhibit Zika Virus Replication

Multi-Omics Studies towards Novel Modulators of Influenza A Virus–Host Interaction

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