2024
DOI: 10.1007/s00018-024-05204-4
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Phosphorylation of the compartmentalized PKA substrate TAF15 regulates RNA–protein interactions

Andreas Feichtner,
Florian Enzler,
Valentina Kugler
et al.

Abstract: Spatiotemporal-controlled second messengers alter molecular interactions of central signaling nodes for ensuring physiological signal transmission. One prototypical second messenger molecule which modulates kinase signal transmission is the cyclic-adenosine monophosphate (cAMP). The main proteinogenic cellular effectors of cAMP are compartmentalized protein kinase A (PKA) complexes. Their cell-type specific compositions precisely coordinate substrate phosphorylation and proper signal propagation which is indis… Show more

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