Phosphotyrosine Phosphatases in Cancer Diagnostic and Treatment

Abstract

The activation of proteins by post-translational modification represents an important cellular mechanism for regulating most aspects of biological organization and control, including growth, development, homeostasis, and cellular communication. The complexity of protein modification includes phosphorylation and dephosphorylation, on proteins of different signaling pathways corresponding to growth, development, disease states, and aging. Current patents in phosphotyrosine phosphatases signaling pathway are focusing in diagnosis, prognosis and treatment. Many, new diagnosis techniques detect changes in mRNA expression with microarray technologies and others introduced specific antibodies for detection proteins changes, introducing to Biomedicine at Transcriptomic and Proteomic era. Many recent invent development alternative therapy with antibodies and inhibitors to PTPs that demonstrate the need to deepen understanding of the molecular mechanisms involved in the development of cancer.

Should I stay or should I go? Shedding of RPTPs in cancer cells switches signals from stabilizing cell-cell adhesion to driving cell migration

“…Changes in RPTPs at the protein level such as cleavage of PTPμ and PTPκ have been associated with tumor progression. 7,8 For a comprehensive review of RPTPs associated with human cancers, see Julien et al For microarray studies focused on PTPs in cancer see Tiscornia et al 9 and McArdle et al 10 Cell adhesion molecules (CAMs) are transmembrane glycoproteins expressed on the cell surface that mediate both cellcell and cell-ECM interactions. Cell-cell CAMs include the cadherins and immunoglobulin (Ig)-like CAMs while integrins mediate cell-ECM adhesions.…”