Phosphotyrosine protein phosphatase and diabetic pregnancy: an association between low molecular weight acid phosphatase and degree of glycemic control

Gloria‐Bottini, F.; Gerlini, G; Lucarini, N.; Borgiani, Paola; Amante, A.; Torre, M. La; Antonacci, E.; Bottini, E.

doi:10.1007/bf01919537

Cited by 32 publications

(25 citation statements)

References 19 publications

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“…On the other hand, Vmax of F isoform is much higher for B3P than for insulin receptor, whereas Vmax of S isoform shows similar but less marked difference. This could be a biochemical basis for the differences observed between ACP 1 genotypes concerning the glycemic level that have been observed in normal and diabetic subjects [20,21].…”

Section: Discussionmentioning

confidence: 74%

A study of acid phosphatase locus 1 in women with high fat content and normal body mass index

Lorenzo¹,

Renzo²,

Puja³

et al. 2009

Metabolism

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De Lorenzo and coworkers have recently described a class of women with normal body mass index (BMI) and high fat content (normal weight obese syndrome [NWO]). This observation prompted us to study the possible role of acid phosphatase locus 1 (ACP 1 ) in the differentiation of this special class of obese subjects. Acid phosphatase locus 1 is a polymorphic gene associated with severe obesity and with total cholesterol and triglycerides levels. The enzyme is composed by 2 isoforms-F and S-that have different biochemical properties and probably different functions. The sample study was composed of 130 white women from the population of Rome. Total fat mass and percentage of fat mass were measured by dual-energy x-ray absorptiometry. Thirty-six women had a BMI less than 25 and percentage of fat mass greater than 30 (high fat, normal BMI [HFHB]), and 94 women showed a BMI greater than 25 and a percentage of fat mass greater than 30 (high fat, high BMI [HFHB]). In the whole sample, the proportion of low-activity ACP 1 genotypes (*A/*A and *B/*A) was higher than in controls. However, whereas HFNB showed a very high frequency of ACP 1 *A/*A genotype, high-fat, high-BMI women showed an increase of *B/*A genotype. These 2 genotypes differ in the concentration of F isoform and the F/S ratio, which are lower in ACP 1 * A/*A genotype than in ACP 1 * B/*A genotype. The genetic differentiation of the class of women with normal BMI and high fat content from the class showing a concordant level of the 2 parameters supports the hypothesis that HFNB class represents a special cluster of obese subjects not revealed by BMI evaluation. Because ACP 1 is present in adipocytes, the present observation suggests that F isoform may have a specific role in the regulation of quantity of adipose tissue.

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Section: Discussionmentioning

confidence: 74%

A study of acid phosphatase locus 1 in women with high fat content and normal body mass index

Lorenzo¹,

Renzo²,

Puja³

et al. 2009

Metabolism

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“…ACP1 has previously been found to be associated with glucose levels in diabetics [23], with lower levels in subjects carrying the low activity ACP1 *A/*A and *A/*B genotypes. This is probably due to the lower dephosphorylating action of ACP1 on the insulin receptor [12] and on the band 3 protein of the cytoskeleton [24].…”

Section: Discussionmentioning

confidence: 99%

ACP1 Genetic Polymorphism and Coronary Artery Disease: An Association Study

Banci¹,

Saccucci²,

D’Annibale³

et al. 2009

Cardiology

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Objectives: Assuming an immune component in the pathogenesis of atherosclerosis, we have investigated a possible association between coronary artery disease (CAD) and the acid phosphatase locus 1 (ACP1) genetic polymorphism, which has previously been found to be associated with immune disorders. Methods: 226 subjects admitted to the hospital for CAD, 358 consecutive newborn infants, 279 adult subjects with type 2 diabetes without CAD and 137 adults without diabetes and without CAD from the Caucasian population of Rome were studied. The ACP1 genotype was determined by DNA analysis. Statistical analyses were performed using the SPSS package. Results: CAD females showed an excess of ACP1 *A/*C and *B/*C genotypes and a deficiency of ACP1 *B/*B genotype compared to controls, while CAD males did not show significant differences. Among diabetic women the proportion of *C allele carriers was much greater in those with CAD than in those without CAD. This difference was much less evident in nondiabetic women. Conclusion: ACP1 may be involved in susceptibility to CAD. Since ACP1 has been found to be associated with immunological diseases, our observation reinforces the notion of an immune component in the pathogenesis of atherosclerosis.

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“…Protein Tyrosine Phosphatase in glucose metabolism is suggested by several lines of evidence: Insulin receptors and Band 3 Protein (B3P) are hydrolyzed by cLMWPTP [1]; diabetic subjects with low enzymatic activity have low glycemic level [2,3]; lowering enzyme activity by a specific antisense oligonucleotide improves insulin sensitivity and decrease blood glucose level in obese mice [4]. On these basis cLMWPTP could be considered a candidate gene for Type 2 Diabetes.…”

Section: Check For Updatesmentioning

confidence: 99%

Age at the Onset of Type 2 Diabetes Correlates with Phenotype of Low Molecular Weight Protein Tyrosine Phosphatase

Gloria‐Bottini¹,

Antonacci²,

Neri³

et al. 2018

Int J Diabetes Clin Res

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Phosphotyrosine protein phosphatase and diabetic pregnancy: an association between low molecular weight acid phosphatase and degree of glycemic control

Cited by 32 publications

References 19 publications

A study of acid phosphatase locus 1 in women with high fat content and normal body mass index

A study of acid phosphatase locus 1 in women with high fat content and normal body mass index

ACP1 Genetic Polymorphism and Coronary Artery Disease: An Association Study

Age at the Onset of Type 2 Diabetes Correlates with Phenotype of Low Molecular Weight Protein Tyrosine Phosphatase

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