Photic damage to the eye: selective extinction of the c-wave of the electroretinogram

Skoog, Klas-Olav; Jarkman, Sven

doi:10.1007/bf00143215

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…This result indicates a deterioration of the pigment epithelium. These findings are in accordance with the results of Skoog and Jarkman's studies [11].…”

Section: Discussionsupporting

confidence: 83%

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Intraoperative retinal light damage reflected in electrophysiologic data

et al. 1991

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In a series of 30 unilaterally pseudophakic patients, electroretinograms and electrooculograms were recorded 6 months postoperatively. The unoperated on fellow eyes served as controls. High intraoperative retinal light exposure (3.4-7.3 mW/cm2, Zeiss OPMI6 operating microscope) caused a substantial reduction of electrophysiologic potentials. Light protection prevented deterioration of electroretinogram and electro-oculogram potentials; reducing the bulb voltage, tilting the axis of illumination, filtering short wavelengths and the use of light shields resulted in 4-log-unit lower intensities (0.8-3.7 microW/cm2).

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“…This result indicates a deterioration of the pigment epithelium. These findings are in accordance with the results of Skoog and Jarkman's studies [11].…”

Section: Discussionsupporting

confidence: 83%

“…The minimal damaging dose of light in rats was estimated to be about 1/~W/cm 2 for 1 hour. Skoog and Jarkman [11] exposed albino rats to strong visible light. They studied the photic damage of the retina and the pigment epithelium by recording the a-and b-waves and the c-wave.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative retinal light damage reflected in electrophysiologic data

et al. 1991

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“…When the major dc-ERG components were quantified for wild-type and Cre +/+ mice in the individual waveforms, there was no significant difference for any of them ( Figure 6D ). Preservation of the c-wave and other dc-ERG components indicates that the major ion currents of the RPE as well as its tight junction structure are unperturbed in Rpe65 CreERT2 mice ( 58 , 59 ).…”

Section: Resultsmentioning

confidence: 99%

An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease

Choi¹,

Suh²,

Einstein³

et al. 2021

JCI Insight

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The retinal pigment epithelium (RPE) provides vital metabolic support for retinal photoreceptor cells and also is an important player in numerous retinal diseases. Gene manipulation in mice using the Cre-LoxP system is an invaluable tool for studying the genetic basis of these retinal diseases. However, existing RPE-targeted Cre mouse lines have critical limitations that restrict their reliability for studies of disease pathogenesis and treatment, including mosaic Cre expression, inducer-independent activity, off-target Cre expression, and intrinsic toxicity. Here, we report the generation and characterization of a knock-in mouse line in which a P2A-CreER T2 coding sequence is fused with the native RPE-specific 65 kDa protein (Rpe65) gene for co-translational expression of CreER T2 . Cre +/mice were able to recombine a stringent Cre reporter allele with >99% efficiency and absolute RPE specificity upon tamoxifen induction at both post-natal days (PD) 21 and 50. Tamoxifen-independent Cre activity was negligible at PD64. Moreover, tamoxifen-treated Cre +/mice displayed no signs of structural or functional retinal pathology up to 4 months of age. Despite weak RPE65 expression from the knock-in allele, visual cycle function was normal in Cre +/mice. These data indicate that Rpe65 CreERT2 mice are wellsuited for studies of gene function and pathophysiology in the RPE.

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“…The L/D ratio was almost extinguished (<110%) in the edematous stage (Francois et al 1978), and the amplitudes of the transient phenomenon in EOG (equal to the c-wave of ERG) were reduced temporarily (Toyama et al 1980). In a study of photic damage to the retina and pigment epithelium (Skoog & Jarkman 1985), the exposure to strong visible light also gave rise to striking changes in the ERG, they had a 25% decrease in the b-wave but a total disappearance of the c-waves. The acute effects of photocoagulation on the retina may help explain this finding.…”

Section: Discussionmentioning

confidence: 99%

The influence of argon laser panretinal photocoagulation on the rabbit ERG c‐wave

Chuang

Arai

Tsukada

et al. 1992

Acta Ophthalmologica

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We observed the influence of panretinal photocoagulation on the ERG c-wave in rabbit eyes. DC-registered ERGs were recorded from rabbit eyes before and after photocoagulation, and compared with those of the fellow eyes. The rabbits were subdivided into 3 groups according to application numbers: 500, 1000, and 1500 spots. The ERG c-waves were found to have totally disappeared in all rabbits 3 days after panretinal photocoagulation, then reappeared with various intervals. In the 500 spot group, the c-wave reappeared after one week, and almost reached control levels in one and a half months. In the 1000 spot group, a 10 day delay was noted, and 90% of control levels were regained after 6 months. In the 1500 spot group, the c-wave didn't reappear until 2 weeks later, and regained 70% (of the control level) after 6 months. The recovery rates were related to the number of laser applications. These results indicate that the ultimate degree of recovery in c-wave amplitude and the time required for the reestablishment of retinal pigment epithelium function both depend on the size of the coagulated area.

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Photic damage to the eye: selective extinction of the c-wave of the electroretinogram

Cited by 6 publications

References 8 publications

Intraoperative retinal light damage reflected in electrophysiologic data

Intraoperative retinal light damage reflected in electrophysiologic data

An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease

The influence of argon laser panretinal photocoagulation on the rabbit ERG c‐wave

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