Photic maculopathy: A review of the literature (II)

Martín-Moro, J. González; Hernández-Verdejo, José Luis; Zarallo-Gallardo, J.

doi:10.1016/j.oftale.2018.10.001

Cited by 8 publications

(11 citation statements)

References 75 publications

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“…Oxidative damage to the retina is commonly induced by prolonged eye exposure to natural or anthropogenic light sources resulting in progression of light retinopathy (light/photic maculopathy) [6,7,8,9,10]. Having accumulated over years, light-induced injuries were suggested to provoke age-related macular degeneration (AMD), the leading cause of vision deterioration and blindness in the elderly [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…The latter include, for instance, iatrogenic light-induced retinopathies caused by illumination from various devices such as slit lamps, indirect ophthalmoscopes, fiber optic endo-illuminators and light sources of operative microscopes [21,22]. Current advances in ophthalmic surgery and eye care increased the incidence of iatrogenic photochemical damage to the retina, which thereby represents another relevant problem of modern ophthalmology [9,10,21].…”

Section: Introductionmentioning

confidence: 99%

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Suppression of Light-Induced Oxidative Stress in the Retina by Mitochondria-Targeted Antioxidant

et al. 2018

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Light-induced oxidation of lipids and proteins provokes retinal injuries and results in progression of degenerative retinal diseases, such as, for instance, iatrogenic photic maculopathies. Having accumulated over years retinal injuries contribute to development of age-related macular degeneration (AMD). Antioxidant treatment is regarded as a promising approach to protecting the retina from light damage and AMD. Here, we examine oxidative processes induced in rabbit retina by excessive light illumination with or without premedication using mitochondria-targeted antioxidant SkQ1 (10-(6’-plastoquinonyl)decyltriphenyl-phosphonium). The retinal extracts obtained from animals euthanized within 1–7 days post exposure were analyzed for H2O2, malondialdehyde (MDA), total antioxidant activity (AOA), and activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD) using colorimetric and luminescence assays. Oxidation of visual arrestin was monitored by immunoblotting. The light exposure induced lipid peroxidation and H2O2 accumulation in the retinal cells. Unexpectedly, it prominently upregulated AOA in retinal extracts although SOD and GPx activities were compromised. These alterations were accompanied by accumulation of disulfide dimers of arrestin revealing oxidative stress in the photoreceptors. Premedication of the eyes with SkQ1 accelerated normalization of H2O2 levels and redox-status of lipids and proteins, contemporarily enhancing AOA and, likely, sustaining normal activity of GPx. Thus, SkQ1 protects the retina from light-induced oxidative stress and could be employed to suppress oxidative damage of proteins and lipids contributing to AMD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Suppression of Light-Induced Oxidative Stress in the Retina by Mitochondria-Targeted Antioxidant

et al. 2018

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“…Solar retinopathy occurs due to photochemical injury occurring in the macula following prolonged exposure to light, like sungazing, eclipse viewing, exposure to welding light, and following endoillumination in rare scenarios. [ 1 ] It presents as blurry vision, metamorphopsia, central scotoma, or dyschromatopsia. Diagnosis is made based on the presence of specific history and multimodal imaging including optical coherence tomography (OCT), OCTA, and autofluorescence.…”

Section: Discussionmentioning

confidence: 99%

The yellow fovea

Mohan

Mohankumar

Rajan

2023

Indian Journal of Ophthalmology

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“…The finding is in agreement with the literature, which cites VA in solar maculopathy generally from 20/40 to 20/60, ranging from 20/20 to CF. (20,38,39) Regarding the VA of the last three patients at diagnosis, Patient D had a vision of CF at 1m in his affected eye. Although vision differs greatly in relation to the first three, this magnitude of visual loss in solar maculopathy has already been described in several cases in the literature, being related to macular thickness and disruption width -changes that were in fact observed in the patient's OCT.…”

Section: Discussionmentioning

confidence: 99%

Comparing six cases of external macular holes and literature review

Cenovicz,

Robaina,

Zanatta

et al. 2023

Revista Brasileira De Oftalmologia

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The characteristic optical coherence tomography finding in solar maculopathy is a well-defined outer retinal hyporeflective space primarily involving the photoreceptor inner and outer segment layers. This typical optical coherence tomography image may be present in a few other pathologies, which currently constitute their main differential diagnoses. Our study shows the report of 12 eyes of 6 patients treated at the Hospital de Olhos do Paraná, presenting their clinical history and diagnostic images, with the purpose of comparing the findings of the first 3 patients (diagnosed with solar maculopathy) with the last 3 patients, which are also cases of external macular holes. RESUMOO achado característico da tomografia de coerência óptica na maculopatia solar é um espaço hiporrefletivo retiniano externo bem definido, envolvendo principalmente as camadas dos segmentos interno e externo dos fotorreceptores. Essa imagem típica da tomografia de coerência óptica pode estar presente em algumas outras patologias, que atualmente constituem seus principais diagnósticos diferenciais. Nosso estudo mostra o relato de 12 olhos de 6 pacientes atendidos no Hospital de Olhos do Paraná, apresentando sua história clínica e imagens diagnósticas, com o objetivo de comparar os achados dos 3 primeiros pacientes (diagnosticados com maculopatia solar) com os 3 últimos pacientes, que também são casos de buracos maculares externos.

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Photic maculopathy: A review of the literature (II)

Cited by 8 publications

References 75 publications

Suppression of Light-Induced Oxidative Stress in the Retina by Mitochondria-Targeted Antioxidant

Suppression of Light-Induced Oxidative Stress in the Retina by Mitochondria-Targeted Antioxidant

The yellow fovea

Comparing six cases of external macular holes and literature review

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