Photo- and electro-chemical strategies for the activations of strong chemical bonds

Abstract

Activating inert feedstocks with strong bonds to synthesize value-added complex molecules is a crucial future target for chemistry. Herein, we present photo-, electro- and photoelectrochemical methods for strong carbon-heteroatom bond activations.

Site-selective C(sp3)–H functionalization of primary aliphatic amines

“…In the past decades, photoredox catalysis has emerged as a powerful tool for the formation of carbon–carbon and carbon–heteroatom bonds in modern organic synthesis. 35 There are many reports on the photoinduced formation of α-amino carbon radical species from secondary and tertiary amines via a single-electron oxidation–deprotonation pathway. 5,6 Because of its higher oxidation potential and tendency towards over-oxidation, the photocatalytic α-C(sp 3 )–H functionalization of primary aliphatic amines has been investigated rarely.…”

Electroreduction strategy: a sustainable tool for the generation of aryl radicals

“…3 Frequently, aryl halides have higher reduction potentials, especially aryl chlorides and fluorides, making their single-electron reduction extremely difficult (Scheme 2). 15 Therefore, it is still a formidable challenge to realize the downstream functionalization of inert aryl halides. The electroreduction strategy is considered a green, efficient, and controllable alternative for the reductive dehalogenation of aryl halides owing to its extraordinary potential range.…”

Recent Advances in Dearomative Partial Reduction of Benzenoid Arenes

“…It should be noted that the scope of this review can't be comprehensive that the dearomative partial reduction by heterogeneous, [5] enzymatic [6] and transition-metal mediated stepwise approaches [7] have been reviewed previously. Recent insightful reviews focusing on the diverse topics of dearomatization reactions by Sarlah, [8] You and Zheng, [9] Zhou, [10] Fan, [11] Glorius, [12] Inoue, [13] Barham and Chiba [14] are also available in the literatures.…”