Photo-bactericidal Properties of Hydroxyapatite Implant Surface Coating

Abstract

Implant-associated infection is a common postoperative complication and remains a serious problem in the surgery. This work describes the development of hydroxyapatite implants with photo-bactericidal properties by the surface coating. The unique coating as crystalline nanoparticles of IR photosensitizers of implant was investigated using infrared spectroscopy. It has been proved that by the interaction of nanoparticles covering implant with the polar solvent, which simulates the interaction of the implant with the biocomponents in vivo (fast proliferating and with immune-competent cells), IR photosensitizers nanoparticles change the spectroscopic properties, becoming fluorescent and phototoxic.Thus, the developed coating based on crystalline IR photosensitizer nanoparticles with studied specific properties should have antibacterial, anti-inflammatory effect by the photodynamic treatment in the near implant area. This research opens the prospect of such technology application in order to provide the local inflammatory and autoimmune reactions prevention in the area of implantation that will improve implant antimicrobial effects and reduce potential long-term cytotoxicity. The results of the study suggest a promising this technology in order to create implants with photo-bactericidal properties.

Graphene Oxide-Modified Hydroxyapatite Nanocomposites in Biomedical Applications: A Review

“…Implant techniques have found utilization in many areas of medicine (orthopaedics, cardiovascular, dentistry, traumatology and neurosurgery). Surgical intervention with subsequent implantation influence post-operative recovery, preventing inflammatory responses and of the implant rejection processes [17]. The crucial characteristics of well-designed implants include porosity, elastic biocompatibility, appropriate mechanical strength, low surface friction, corrosion resistance, improved tribology, ability to reduce inflammation and reduced bacterial adhesion to the surface.…”

“…Scientists have eagerly embraced graphene as it is a lighter and cheaper alternative to existing metal conductors [50]. Benefits of GO include low cost, accessibility and the ability to alter graphene [17].…”

“…Figure 2shows the structure and implant of HA.DISCUSSIONIn situ synthesis of HA To date, many diverse methods have been published for the preparation of HA nanoparticles, while growing interest in the manufacture of HA means that a) b) Packaging structure of hydroxyapatite crystal with the chemical formula Ca 10 (PO 4 ) 6 (OH) 2 (a) and digital photo of hydroxyapatite implant (b)[17].…”