Experimental design DoE (box behnken design BBD) and statistical analysis approaches were employed to determine the effect of Congo red dye (C.R) concentration, photo catalyst dose (Fe+2) and follow of oxygen gas as an oxidant on the degradation of C.R. The results show that the concentration oppositely affects the degradation yield whereas the remaining two factors show positive effect, throughout all experiments oxygen molecule shows crucial role in their positive effect with p-value about 0.01 which is very significant value. The accepted regression model was linear with significance p-value 0.032 that mean all factors show good agreement in linear relationship and the interactions was not important. Degradation kinetics was also applied to investigate the effect of increasing dye concentration on degradation rate constant with and without photo catalyst dose and oxidant (O2). It appears that the degradation of peak at 498nm is second order The result was in good agreement with that of statistical analysis that are 0.0435, 0.0545 and 5.4 M- min- with photo catalysis 12, 8 and 4 PPM dye, 4O2 mL/min,20PPM Fe+2 respectively, in case without photocatalyst the results were 0.0025 and 0.0207 M- min-with 12 and 4 PPM in turn.