Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO3 Nanoparticles

AbuMousa, Rasha A.; Baig, Umair; Gondal, M.A.; AlSalhi, Mohamad S.; Alqahtani, Fulwah Yahya; Akhtar, Sultan; Aleanizy, Fadilah Sfouq; Dastageer, M.A.

doi:10.1038/s41598-018-33434-7

Cited by 41 publications

(14 citation statements)

References 26 publications

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“…After deconvolution, the peaks located at 710.4 and 724.0 eV were attributed to Fe 2+ and the peaks centered at 711.8 and 725.4 eV were assigned to Fe 3+ . Inspection of the W 4f spectrum (Figure c) showed strong signals at 35.2 and 37.2 eV, which confirms the existence of WO 3 . The spectrum of C 1s can be divided into three peaks centered at 287.7, 284.5, and 284.1 eV, suggesting the existence of CO, WC, and CO respectively, which further confirmed the formation of tungsten carbide (Figure d) .…”

Section: Resultssupporting

confidence: 57%

Enhancing Oxygen Evolution Reaction through Modulating Electronic Structure of Trimetallic Electrocatalysts Derived from Metal–Organic Frameworks

Zhao

et al. 2019

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.201901940. The construction of efficient, durable, and non-noble metal electrocatalysts for oxygen evolution reaction (OER) is of great value but challenging. Herein, a facile method is developed to synthesize a series of trimetallic (W/Co/Fe) metal-organic frameworks (MOFs)-derived carbon nanoflakes (CNF) with various Fe content, and anFe-dependent volcano-type plot can be drawn out for WCoFe x -CNF. The optimized WCoFe 0.3 -CNF (when the feed ratio of Fe/Co is 0.3) demonstrates superior electrocatalytic performance with a low overpotential of only 254 mV@10 mA cm −2 and excellent durability of 100 h. Further researches show that appropriate amount of iron doping can regulate the electronic structure, resulting in a favorable synergistic environment. This method may stimulate the exploration of electrocatalysts by utilizing MOFs as precursors while realizing electronic modulation by multimetal doping. Electrocatalysis www.advancedsciencenews.com

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Section: Resultssupporting

confidence: 57%

Enhancing Oxygen Evolution Reaction through Modulating Electronic Structure of Trimetallic Electrocatalysts Derived from Metal–Organic Frameworks

Zhao

et al. 2019

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168

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“…The absorption wavelength of Ce/ZnO shifted to lower wavelengths with an increase in Ce ion doping. The optical absorption coefficient (α) can be calculated as follows [12,46,47]:…”

Section: Resultsmentioning

confidence: 99%

Cerium-Oxide-Nanoparticle-Decorated Zinc Oxide with Enhanced Photocatalytic Degradation of Methyl Orange

et al. 2020

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Cerium-oxide-nanoparticle-decorated zinc oxide was successfully prepared using a simple one-pot hydrothermal technique with different weight% Ce doping. It was found that an increase in Ce doping has an effect on the optical energy band-gap tunability. Ce dopant provides electron trapping on Ce/ZnO nanocomposites and also acts as a surface defect generator during hydrothermal processing. Additionally, a bi-metal oxide heterojunction forms, which acts as a charge separator to obstruct charge recombination and to increase the photodegradation performance. It was found that the methyl orange (MO) degradation performance improved with an increase in Ce doping. The decomposition of MO went from 69.42% (pristine ZnO) to 94.06% (7% Ce/ZnO) after 60 min under fluorescent lamp illumination.

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“…The cytotoxicity of the CNPs was investigated using Alamar Blue as previously described. 34 Briefly, HeLa (human cervical cancer epithelial cells) were obtained from American Type Culture Collection (ATCC CCL-2) and seeded in 24 wells in DMEM media supplemented with 10% FBS, and 1% antibiotic-antimycotic overnight, until 70% to 90% confluency had been reached. Then, the cells were treated with the CNPs (2.5-0.016 mg/mL, for 24 and 48 hours).…”

Section: Cell Viability Analysismentioning

confidence: 99%

<p>Antibacterial Activity of Chitosan Nanoparticles Against Pathogenic N. gonorrhoea</p>

Alqahtani

Aleanizy

Tahir

et al. 2020

IJN

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The emergence of Neisseria gonorrhoeae strains that are resistant to the most commonly used antibiotics represents a great concern for global public health. This challenges the effectiveness of clinical treatment regimens and demands the development of alternative antigonococcal agent. In this regard, chitosan nanoparticles (CNPs) are known to have antimicrobial activity against a wide range of pathogens. Thus, they have become a potential candidate for combatting this era of multi-drug resistance. This study aims to formulate CNPs, characterize their physicochemical properties, and examine their antimicrobial activity against gonococcus. Materials and Methods: The ionic gelation method was used to prepare CNPs of different concentrations. Characterization for their particle size (PZ), polydispersity index (PDI), and zeta potential (ZP) was performed. The anti-microbial activity of CNPs was investigated against 13 WHO N. gonorrhoeae reference strains, using the broth dilution method. Cytotoxicity of CNPs and their effect on bacterial adhesion to HeLa cells were investigated. Results: The average PZ and ZP of the prepared NPs were increased when the concentration of chitosan was increased from 1 to 5 mg/mL and found to be in the range of 193 nm ± 1.9 to 530 nm ± 13.3, and 14 mV ± 0.5 to 20 mV ± 1, respectively. Transmission electron microscopes (TEM) images revealed spherical NPs, and the NPs had a low PDI value of ≤0.27. The formed CNPs produced antibacterial activity against all tested strains, including those resistant to multiple antibiotics, with a minimum inhibitory concentration (MIC 90) of 0.16 to 0.31 mg/ mL and a minimum bactericidal concentration (MBC) of 0.31 to 0.61 mg/mL. Of note, at all MIC 90 and MBC, the CNPs had no significant cytotoxic effect on HeLa cells and reduced bacterial adhesion to these cells at MBC doses. Conclusion: The present work findings suggest the potential of the CNPs for the treatment of gonorrhoea.

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Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO3 Nanoparticles

Cited by 41 publications

References 26 publications

Enhancing Oxygen Evolution Reaction through Modulating Electronic Structure of Trimetallic Electrocatalysts Derived from Metal–Organic Frameworks

Enhancing Oxygen Evolution Reaction through Modulating Electronic Structure of Trimetallic Electrocatalysts Derived from Metal–Organic Frameworks

Cerium-Oxide-Nanoparticle-Decorated Zinc Oxide with Enhanced Photocatalytic Degradation of Methyl Orange

<p>Antibacterial Activity of Chitosan Nanoparticles Against Pathogenic N. gonorrhoea</p>

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