Photo-excitation energy transfer between a titanium(iv)–porphyrin complex and oxygen molecule

Matsumoto, Takatoshi; Takamura, Kiyoko

doi:10.1039/c2ay25683e

Cited by 8 publications

(8 citation statements)

References 36 publications

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“…24 in Figure S18) to an oxygen molecule when it approached the porphyrin ring (Figure S19). The above results, along with those reported previously on the titanium(IV)−porphyrin, 28 are consistent with the following PDT process. As schematically shown in Figure 7B, the COP-P-SO 3 H complex is turned from its ground state into the excited state upon NIR photoexcitation.…”

Section: ■ Results and Discussionsupporting

confidence: 93%

Two-Dimensional Fully Conjugated Polymeric Photosensitizers for Advanced Photodynamic Therapy

Xiang

Zhu

et al. 2016

Chem. Mater.

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Photodynamic therapy (PDT) is attractive for treatment of various cancers, with a high selectivity, minimal long-term effect, and excellent cosmetic appeal. Well water-dispersive photosensitizers with strong optical absorption within the tissue transparency window (700−1000 nm) are needed for efficient PDT. However, clinically used PDT agents based on oligomeric porphyrin units (e.g., protoporphyrin IX) are effective at 532 nm irradiation only. Herein, we synthesized a two-dimensional covalent organic polymer (COP) containing fully conjugated multiple porphyrin macrocycles with sulfonic acid side groups. The resultant COP-P-SO 3 H is well water-dispersive, showing strong optical absorption within the desired therapeutic window and a high quantum yield of reactive oxygen species, especially singlet oxygen ( 1 O 2 ), for efficiently killing tumor cells upon near-infrared light irradiation. Our first-principles calculations revealed that the observed high yield 1 O 2 resulted from the unique side-on parallel diatomic adsorption (Yeager mode) of triplet oxygen molecules on the highly conjugated porphyrin rings in the photoexcited COP-P-SO 3 H.

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Section: ■ Results and Discussionsupporting

confidence: 93%

Two-Dimensional Fully Conjugated Polymeric Photosensitizers for Advanced Photodynamic Therapy

Xiang

Zhu

et al. 2016

Chem. Mater.

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“…Porphyrins and their metal complexes are well known as highly effective triplet state photosensitizers to be capable of producing 1 O 2 singlet molecular oxygen . Like the light energy, the US excitation energy possibly generated the metalloporphyrin triplet excited state ( 3 MTTP*), which in turn, was intercepted efficiently by the surrounding molecular oxygen to give 1 O 2 , successfully used for SDT (Figure f) .…”

Section: Resultsmentioning

confidence: 99%

Metalloporphyrin Complex‐Based Nanosonosensitizers for Deep‐Tissue Tumor Theranostics by Noninvasive Sonodynamic Therapy

Chen

Cui

et al. 2018

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Metal complexes are widely used as anticancer drugs, while the severe side effects of traditional chemotherapy require new therapeutic modalities. Sonodynamic therapy (SDT) provides a significantly noninvasive ultrasound (US) treatment approach by activating sonosensitizers and initiating reactive oxygen species (ROS) to damage malignant tissues. In this work, three metal 4‐methylphenylporphyrin (TTP) complexes (MnTTP, ZnTTP, and TiOTTP) are synthesized and encapsulated with human serum albumin (HSA) to form novel nanosonosensitizers. These nanosonosensitizers generate abundant singlet oxygen (1O2) under US irradiation, and importantly show excellent US‐activatable abilities with deep‐tissue depths up to 11 cm. Compared to ZnTTP‐HSA and TiOTTP‐HSA, MnTTP‐HSA exhibits the strongest ROS‐activatable behavior due to the lowest highest occupied molecular orbital−lowest unoccupied molecular orbital gap energy by density functional theory. It is also effective for deep‐tissue photoacoustic/magnetic resonance dual‐modal imaging to trace the accumulation of nanoparticles in tumors. Moreover, MnTTP‐HSA intriguingly achieves high SDT efficiency for simultaneously suppressing the growth of bilateral tumors away from ultrasound source in mice. This work develops a deep‐tissue imaging‐guided SDT strategy through well‐defined metalloporphyrin nanocomplexes and paves a new way for highly efficient noninvasive SDT treatments of malignant tumors.

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“…The interest towards compounds 3a-c arises from the potential application of these molecules as catalysts in oxygen reduction reaction (ORR), [11,12] as dyes in dye sensitized solar cells (DSSC), [13][14][15] and in the detection of hydrogen peroxide. [16] Indeed, the increasing energy demand connected with the replacement of fossil fuels and environmental concerns has made necessary the development of advanced and next-generation technologies for energy production. Among the approaches pursued to enhance these processes, the use of catalysts appears very promising.…”

Section: Introductionmentioning

confidence: 99%

Titanium‐Based Tetrakis‐2,3‐[5,6‐di(Substituted)pyrazino]porphyrazine: Synthesis and Characterization

et al. 2020

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Tetrapyrazinoporphyrazine (TPysPz) ligands and metal complexes find, generally, application as electronic materials and catalysts. Considering the limited application of Titanium (Ti), we prepared and characterized a family of ligands and Ti-based complexes of tetrakis-2,3-[5,6-di-R 8-pyrazino]porphyrazine (R = H, 2-Py, Ph). UV/Vis measurements in different solvents confirm molecular aggregation, which results more pronounced in the presence of 2-pyridil and phenyl substituents on the macrocycle edge. Because of low solubility, solid state NMR was applied for structure characterization.

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Photo-excitation energy transfer between a titanium(iv)–porphyrin complex and oxygen molecule

Cited by 8 publications

References 36 publications

Two-Dimensional Fully Conjugated Polymeric Photosensitizers for Advanced Photodynamic Therapy

Two-Dimensional Fully Conjugated Polymeric Photosensitizers for Advanced Photodynamic Therapy

Metalloporphyrin Complex‐Based Nanosonosensitizers for Deep‐Tissue Tumor Theranostics by Noninvasive Sonodynamic Therapy

Titanium‐Based Tetrakis‐2,3‐[5,6‐di(Substituted)pyrazino]porphyrazine: Synthesis and Characterization

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