Photo-Fenton and Fenton-like processes for the treatment of the antineoplastic drug 5-fluorouracil under simulated solar radiation

Koltsakidou, Αnastasia; Αντωνοπούλου, Μαρία; Sykiotou, Marianthi; Εvgenidou, Εleni; Konstantinou, Ioannis; Lambropoulou, Dimitra A.

doi:10.1007/s11356-016-8138-3

Cited by 38 publications

(9 citation statements)

References 47 publications

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“…In other studies, low toxicity was recorded for the initial solution of 5-FU and the solution at the end of the photo-Fenton-like (sunlight/Fe(III)/Η 2 Ο 2 ) treatment, while an increase in the overall toxicity was observed only at the first stages of Fe(III)/Η 2 Ο 2 and Fe(III)/S 2 O 8 2À processes. All iron-catalyzed processes followed quite similar transformation pathways, which included defluorination-hydroxylation as well as pyrimidine ring opening in 5-FU molecule (Koltsakidou et al 2017).…”

Section: Aops Based On Iron-catalysismentioning

confidence: 99%

Removal of Cytostatic Drugs from Water and Wastewater: Progress in the Development of Advanced Treatment Methods

Siedlecka

2020

Fate and Effects of Anticancer Drugs in the Environment

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Cytostatic drugs and other pharmaceuticals are newly recognized classes of environmental pollutants that receive considerable attention because of their categorization as carcinogenic, mutagenic, and teratogenic compounds. Although the cytostatics belong to currently unregulated trace-level contaminants, this situation can change in the near future. Due to poor biodegradability and low removal efficiency by conventional wastewater treatments, the alternative methods for a successful elimination of these drugs have been developed and investigated. This chapter provides a review of recent scientific research on the elimination of cytostatic drugs from water and wastewater by advanced physicochemical, chemical and biological methods, and advanced oxidation processes. The advanced treatments including membrane filtration, adsorption, ozonation, biomembrane filtration and advanced oxidation processes (AOPs), such as the Fenton reaction, photodegradation under solar and UV irradiation, and electrochemical oxidation, constitute a promising technology for the treatment of water and wastewater containing cytostatic drugs. In the presented review, data published on the degradation of cytostatic drugs by the aforementioned alternative methods have been evaluated for the period 2007-2017. Additional aspects of the problem such as the operating conditions, influence of the aqueous matrix quality on the removal efficacy, decomposition mechanism of cytostatic drugs based on the identified intermediates, and the advantages and disadvantages of the applied processes are also discussed.

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Section: Aops Based On Iron-catalysismentioning

confidence: 99%

Removal of Cytostatic Drugs from Water and Wastewater: Progress in the Development of Advanced Treatment Methods

Siedlecka

2020

Fate and Effects of Anticancer Drugs in the Environment

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“…The equipment used in the study as well as the experimental conditions for the photo-Fenton experiments has been reported in detail previously (Koltsakidou et al 2017b). Briefly, the simulated solar irradiation was conducted by Atlas Suntest CPS+ (Germany), which was equipped with a xenon lamp (< 290 nm) with a constant irradiance of 500 Wm −2 .…”

Section: Photodegradation Experimentsmentioning

confidence: 99%

A comparative study on the photo-catalytic degradation of Cytarabine anticancer drug under Fe3+/H2O2, Fe3+/S2O82−, and [Fe(C2O4)3]3−/H2O2 processes. Kinetics, identification, and in silico toxicity assessment of generated transformation products

Koltsakidou

Αντωνοπούλου

Εvgenidou

et al. 2019

Environ Sci Pollut Res

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Cytarabine (CY) is an anticancer drug which has been identified in wastewater influents, effluents, and surface waters. In the present study, the degradation of CYunder simulated solar light (SSL), by photo-Fenton (Fe 3+ /H 2 O 2 /SSL) and photo-Fenton-like processes (Fe 3+ /S 2 O 8 2− /SSL and [Fe(C 2 O 4 ) 3 ] 3− /H 2 O 2 /SSL), was investigated. The major parameters affecting the applied treatments (e.g., concentration of CY, Fe 3+ , H 2 O 2 , and S 2 O 8 2−) were optimized and CY's complete removal was achieved within 45 min for all techniques used. Mineralization studies indicated that [Fe(C 2 O 4 ) 3 ] 3− /H 2 O 2 /SSL treatment was the most efficient procedure since faster kinetics are achieved and higher mineralization percentage is reached compared to the other techniques used. Furthermore, 12 transformation products (TPs) were identified during the applied processes, by high resolution mass spectrometry, four of which were identified for the first time, indicating that CY molecule undergoes hydroxylation and subsequent oxidation, during the applied processes. Moreover, predictions of acute and chronic ecotoxicity of CY and its TPs on fish, daphnia, and green algae were conducted, using in silico quantitative structure activity relationship (QSAR) calculations. According to these predictions, the TPs generated during the studied treatments may pose a threat to aquatic environment. Finally, the efficiency of CY degradation by photo-Fenton and photo-Fenton-like treatment in real wastewater was evaluated, under the optimized conditions, which resulted in lower degradation rate constants compared to ultrapure water.

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“…Nevertheless, the traditional homogenous Fenton processes include obvious and inevitable shortcomings, such as production of iron containing sludge, low pH (pH < 3.0), large amount of H 2 O 2 , requirement for secondary treatment and difficult regeneration of the catalyst, which have greatly restricted their wide applications. To solve this problem, a "Fenton-like" reaction, which can surmount the above-mentioned adverse conditions as, for example, the reduction of H 2 O 2 by modifying the process going towards the photo-Fenton reaction, has been considered as one of the most effective methods [26][27][28][29][30][31][32][33][34]. Therefore, the key point is to exploit suitable semiconducting, heterogeneous and Fenton-like catalysts with a wide pH range, high reusability, excellent activity and good stability.…”

Section: Introductionmentioning

confidence: 99%

Hollow Nanospheres Organized by Ultra-Small CuFe2O4/C Subunits with Efficient Photo-Fenton-like Performance for Antibiotic Degradation and Cr(VI) Reduction

et al. 2022

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Hollow transition metal oxides have important applications in the degradation of organic pollutants by a photo-Fenton-like process. Herein, uniform, highly dispersible hollow CuFe2O4/C nanospheres (denoted as CFO/C-PNSs) were prepared by a one-pot approach. Scanning electron microscope (SEM) and transmission electron microscope (TEM) images verified that the CFO/C-PNS catalyst mainly presents hollow nanosphere morphology with a diameter of 250 ± 30 nm. Surprisingly, the photodegradation test results revealed that CFO/C-PNSs had an excellent photocatalytic performance in the elimination of various organic contaminants under visible light through the efficient Fenton catalytic process. Due to the unique hollow structure formed by the assembly of ultra-small CFO/C subunits, the catalyst exposes more reaction sites, improving its photocatalytic activity. More importantly, the resulting magnetically separable CFO/C-PNSs exhibited excellent stability. Finally, the possible photocatalytic reaction mechanism of the CFO/C-PNSs was proposed, which enables us to have a clearer understanding of the photo-Fenton mechanism. Through a series of characterization and analysis of degradation behavior of CFO/C-PNS samples over antibiotic degradation and Cr(VI) reduction, •OH radicals generated from H2O2 decomposition played an essential role in enhancing the reaction efficiency. The present work offered a convenient method to fabricate hollow transition metal oxides, which provided impetus for further development in environmental and energy applications. Highlights: Novel hollow CuFe2O4/C nanospheres were prepared by a facile and cost-effective method. CuFe2O4/C exhibited excellent photo-Fenton-like performance for antibiotic degradation. Outstanding photocatalytic performance was attributed to the specific hollow cavity-porous structure. A possible mechanism for H2O2 activation over hollow CuFe2O4/C nanospheres was detailed and discussed.

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Photo-Fenton and Fenton-like processes for the treatment of the antineoplastic drug 5-fluorouracil under simulated solar radiation

Cited by 38 publications

References 47 publications

Removal of Cytostatic Drugs from Water and Wastewater: Progress in the Development of Advanced Treatment Methods

Removal of Cytostatic Drugs from Water and Wastewater: Progress in the Development of Advanced Treatment Methods

A comparative study on the photo-catalytic degradation of Cytarabine anticancer drug under Fe3+/H2O2, Fe3+/S2O82−, and [Fe(C2O4)3]3−/H2O2 processes. Kinetics, identification, and in silico toxicity assessment of generated transformation products

Hollow Nanospheres Organized by Ultra-Small CuFe2O4/C Subunits with Efficient Photo-Fenton-like Performance for Antibiotic Degradation and Cr(VI) Reduction

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