Photo-induced force microscopy (PiFM) – principles and implementations

Sifat, Abid Anjum; Jahng, Junghoon; Potma, Eric O.

doi:10.1039/d2cs00052k

Cited by 57 publications

(39 citation statements)

References 51 publications

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“…Taking the AFM-IR mode as a more advanced example, this technique aims to characterize the photothermal absorption of the material by combining a laser source and the AFM. AFM-IR have two primary flavors including contact-mode photo-thermal induced resonance (c-PTIR) [ 13 ] and non-contact Photo-induced Force Microscopy (PiFM) [ 14 ]. A revised version for PTIR utilizes a pulsed laser at the resonance of the cantilever as resonance enhanced PTIR, which can be operated either in contact-resonance mode [ 15 ] or tapping mode [ 16 ].…”

Section: Afm Basic Principlesmentioning

confidence: 99%

Review: Advanced Atomic Force Microscopy Modes for Biomedical Research

Xia

2022

Biosensors

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Visualization of biomedical samples in their native environments at the microscopic scale is crucial for studying fundamental principles and discovering biomedical systems with complex interaction. The study of dynamic biological processes requires a microscope system with multiple modalities, high spatial/temporal resolution, large imaging ranges, versatile imaging environments and ideally in-situ manipulation capabilities. Recent development of new Atomic Force Microscopy (AFM) capabilities has made it such a powerful tool for biological and biomedical research. This review introduces novel AFM functionalities including high-speed imaging for dynamic process visualization, mechanobiology with force spectroscopy, molecular species characterization, and AFM nano-manipulation. These capabilities enable many new possibilities for novel scientific research and allow scientists to observe and explore processes at the nanoscale like never before. Selected application examples from recent studies are provided to demonstrate the effectiveness of these AFM techniques.

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Section: Afm Basic Principlesmentioning

confidence: 99%

Review: Advanced Atomic Force Microscopy Modes for Biomedical Research

Xia

2022

Biosensors

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“…Excellent review articles are available explaining the working principle of these methods in-depth. [89,90] As shown by ten Have et al, this so-called AFM-IR or nano-IR technique (specifically, the authors used PiFM) facilitates the accurate detection of PS NPs down to 20 nm in size. [65] The surface sensitivity highlighted a change of spectrum after H 2 O 2 treatment of the (commercially obtained) PS beads.…”

Section: Scanning Probe Microscopymentioning

confidence: 99%

Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms

Mandemaker¹,

Meirer²

2022

Angewandte Chemie

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Nanoplastics (NPs), small (< 1 μm) polymer particles formed from bulk plastics, are a potential threat to human health and the environment. Orders of magnitude smaller than microplastics (MPs), they might behave differently due to their larger surface area and small size, which allows them to diffuse through organic barriers. However, detecting NPs in the environment and organic matrices has proven to be difficult, as their chemical nature is similar to these matrices. Furthermore, as their size is smaller than the (spatial) detection limit of common analytical tools, they are hard to find and quantify. We highlight different micro-spectroscopic techniques utilized for NP detection and argue that an analysis procedure should involve both particle imaging and correlative or direct chemical characterization of the same particles or samples. Finally, we highlight methods that can do both simultaneously, but with the downside that large particle numbers and statistics cannot be obtained.

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“…4 The other family of methods, and an increasingly popular AFM-based infrared spectroscopy method for soft matters, is the AFM-IR, which mechanically detects the photothermal response of the sample due to IR absorption. Since its early conception and demonstration, 5,6 AFM-IR has been developed with different AFM operational modes: 7 the original photothermal induced resonance (PTIR) technique that is based on contact mode, 8,9 photo-induced force microscopy (PiFM), 10,11 or tapping AFM-IR, that is based on tapping mode, 9,12 and peak force infrared (PFIR) microscopy that is based on the peak tapping mode. 13,14 These AFM-IR techniques inherit the same advantages and limitations of their respective AFM operational modes.…”

Section: Introductionmentioning

confidence: 99%