Photo‐induced granulomatous eruption by hydroxyurea

The granulomatous reaction pattern

“…Fibrosis is In the past, cutaneous granulomatous lesions with histology similar to sarcoidosis have been reported in persons exposed to beryllium compounds in industry. 193 Occasionally, keratin from ruptured cysts or hair follicles can induce sarcoidal granulomas rather than the more usual foreign body type of reaction. [190][191][192] Sea urchin spines can produce all types of granuloma, not only sarcoidal ones.…”

Numerous Ulcerated Plaques of the Trunk and Extremities in a Patient Receiving Long-term Hydroxyurea Therapy

“…Histopathologic analysis will distinguish phototoxic eruptions, which may demonstrate vacuolar interface changes, perivascular lymphocytic infiltrates, and rarely noncaseating sarcoidal granulomas. 8 Iatrogenic epidermodysplasia verruciformis is an uncommon, acquired form of epidermodysplasia verruciformes (EV), typically in immunocompromised or immunosuppressed patients. 9 Clinically, there are numerous verrucal papules and nodules of the trunk and extremities.…”

“…Clinically, phototoxic eruptions may present in similar distribution as squamous dysplasia. Histopathologic analysis will distinguish phototoxic eruptions, which may demonstrate vacuolar interface changes, perivascular lymphocytic infiltrates, and rarely noncaseating sarcoidal granulomas …”

Granulomatous Drug Eruptions

“…b Transient fever and bilateral ankle edema in a patient with amlodipine-associated GA. 47 reaction to injectable drugs 66 and vaccinations, 67 photoinduced granulomatous eruption by hydroxyurea, 68 and a characteristic drug eruption secondary to granulocyte colony-stimulating factor (G-CSF) whereby patients presented with an eruption 1 day to 3 weeks after the administration of this medication. Histopathologic analyses of these cases revealed a dermal infiltrate composed primarily of CD68-positive enlarged histiocytes.…”