Photo-protective effects of selected furocoumarins on β-pinene, R-(+)-limonene and γ-terpinene upon UV-A irradiation

Bitterling, Hannes; Lorenz, Peter; Vetter, Walter; Stintzing, Florian C.

doi:10.1016/j.jphotochem.2021.113623

Cited by 6 publications

(6 citation statements)

References 32 publications

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“…Thus it could improve the defense provided by phenolic antioxidants against natural lipids or other oxidizable substrates. [35] Sesquiterpenes and their derivatives were reported to possess broad antioxidant, anti-inflammatory, and antiaging activities. [36,37] Caryophyllene, α-cubebene, germacrene, and copaene found in C.…”

Section: Discussionmentioning

confidence: 99%

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Valorization of Citrus peels: GC/MS‐based metabolites profiling, multivariate analysis, and antiaging potential

El Kady,

Ayoub,

El Mehrate

et al. 2024

Archiv der Pharmazie

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Aging and agro‐waste are major challenges. Natural ingredients are preferred in skincare. This study intended to isolate the essential oils (EO) from the leftover peels obtained from three commonly edible Citrus species fruit peels, namely Citrus paradisi (grapefruit), Citrus sinensis (sweet orange), and Citrus deliciosa (mandarin). Gas chromatography/mass spectrometry analysis identified volatile constituents in EO and headspace aroma. Multivariate analysis distinguished between the three species. The antiaging effects of Citrus EO were assessed in vitro and in silico, studying volatile interactions with target enzymes. C. sinensis peels had the highest oil yield, rich in monoterpenes. C. paradisi and C. deliciosa contained sesquiterpenes. Limonene dominated the hydrodistilled EO: 94.50% in C. paradisi, 96.80% in C. sinensis, and 80.66% in C. deliciosa. Unsupervised multivariate analysis of Citrus species revealed that d‐limonene, γ‐terpinene, and β‐pinene are the key phytochemical markers contributing to their diverse chemical composition. C. paradisi exhibited the highest enzyme inhibitory activity, with IC50 values of 12.82, 27.58, and 18.16 µg/mL for tyrosinase, elastase, and collagenase, respectively. In silico studies showed that the volatiles can inhibit the tested antiaging enzymes. According to these findings, the investigated agro‐waste might slow aging in skin care.

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Section: Discussionmentioning

confidence: 99%

“…Thus it could improve the defense provided by phenolic antioxidants against natural lipids or other oxidizable substrates. [ 35 ]…”

Section: Discussionmentioning

confidence: 99%

Valorization of Citrus peels: GC/MS‐based metabolites profiling, multivariate analysis, and antiaging potential

El Kady,

Ayoub,

El Mehrate

et al. 2024

Archiv der Pharmazie

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“…dulcis (Rutaceae) and C. citratus ; murine fibroblastic cell line 3T3 and rabbit cornea derived cell line SIRC; ( Dijoux et al, 2006 )]. Recently, it has been demonstrated that furanocoumarins may protect terpenes from oxidation ( Bitterling et al, 2022a ; 2022b ). So, it appears that interactions between the single compounds of an EO as well as between different types of MOCS (for example EOs and polyphenols) may have been overlooked in the past and deserve closer examinations.…”

Section: Eos and Their Bio-functional Properties – Risks And Side Eff...mentioning

confidence: 99%

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

et al. 2022

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Essential oils (EOs) and their individual volatile organic constituents have been an inherent part of our civilization for thousands of years. They are widely used as fragrances in perfumes and cosmetics and contribute to a healthy diet, but also act as active ingredients of pharmaceutical products. Their antibacterial, antiviral, and anti-inflammatory properties have qualified EOs early on for both, the causal and symptomatic therapy of a number of diseases, but also for prevention. Obtained from natural, mostly plant materials, EOs constitute a typical example of a multicomponent mixture (more than one constituent substances, MOCS) with up to several hundreds of individual compounds, which in a sophisticated composition make up the property of a particular complete EO. The integrative use of EOs as MOCS will play a major role in human and veterinary medicine now and in the future and is already widely used in some cases, e.g., in aromatherapy for the treatment of psychosomatic complaints, for inhalation in the treatment of respiratory diseases, or topically administered to manage adverse skin diseases. The diversity of molecules with different functionalities exhibits a broad range of multiple physical and chemical properties, which are the base of their multi-target activity as opposed to single isolated compounds. Whether and how such a broad-spectrum effect is reflected in natural mixtures and which kind of pharmacological potential they provide will be considered in the context of ONE Health in more detail in this review.

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“…The proton NMR spectrum of the complex showed a singlet peak at 1.48 ppm, which was attributed to the methyl group (-CH3) attached to nitrogen of the dithiocarbamate, and a multiplet between 6.51-7.38 ppm due to the phenyl group. A pronounced singlet peak at 2.50 ppm emanated from the solvent (dimethylsulfoxide) used for the analysis [24].…”

Section: Nmr Studies Of Ag(i) Complex Of N-methyl-n-phenyl Dithiocarb...mentioning

confidence: 99%

Synthesis and Antioxidant Investigation of Ag2S Nanoparticles Obtained from Silver(I) Complex of N-Methyl-N-Phenyl- Dithiocarbamate

Ajiboye

Onwudiwe

2022

JNanoR

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Monoclinic Ag2S nanoparticles have been synthesized via a thermal decomposition of Ag(I) complex of N-methyl-N-phenyl dithiocarbamate (as a single source precursor) in oleylamine at 180 °C. The complex was characterized by spectroscopic techniques. The decomposition profile was studied using thermogravimetry analysis (TGA) coupled to differential scanning calorimetry (DSC), and the results obtained from these characterization techniques confirmed the formation of the silver dithiocarbamate complex. The Ag2S nanoparticles was characterized using X-ray diffraction, energy dispersive X-ray spectrometer (EDS), transmission electron microscopy (TEM), UV-visible spectroscopy, and fourier transform infra-red (FTIR) spectroscopy. The XRD patterns of the silver sulphide nanoparticles confirmed acanthite phase, with the most prominent (-121) peak identified at 2θ value of 34.39o, while EDS analysis showed Ag:S ratio of 2:1, which agreed with the XRD result. FTIR spectrum revealed the presence of amine groups, thereby confirmed that the synthesized Ag2S was capped by oleylamine. Finally, the antioxidant activity of the Ag2S was determined by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay and it exhibited better antioxidant activities than silver nanoparticles.

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Photo-protective effects of selected furocoumarins on β-pinene, R-(+)-limonene and γ-terpinene upon UV-A irradiation

Cited by 6 publications

References 32 publications

Valorization of Citrus peels: GC/MS‐based metabolites profiling, multivariate analysis, and antiaging potential

Valorization of Citrus peels: GC/MS‐based metabolites profiling, multivariate analysis, and antiaging potential

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

Synthesis and Antioxidant Investigation of Ag<sub>2</sub>S Nanoparticles Obtained from Silver(I) Complex of <i>N</i>-Methyl<i>-N</i>-Phenyl- Dithiocarbamate

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