Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

Ilhami, Fasih Bintang; Peng, Kai-Chen; Chang, Yi-Shiuan; Alemayehu, Yihalem Abebe; Tsai, Hsieh‐Chih; Lai, Juin‐Yih; Chiao, Yu‐Hsuan; Kao, Chen‐Yu; Cheng, Chih‐Chia

doi:10.3390/ijms22010154

Cited by 17 publications

(6 citation statements)

References 57 publications

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“…The in vitro release model of doxorubicin from DOX-loaded micelles was performed using the dynamic dialysis method [ 49 ]. First, the amount of DOX loaded into the three types of micelles was calculated.…”

Section: Methodsmentioning

confidence: 99%

“…The samples were quantified using a fluorescence measurement of DOX emission (592 nm). Each sample was analyzed in triplicate and the result was represented as a cumulative DOX release, which is a parameter calculated using the following formula [ 49 ]:

where W t is the amount of DOX released at time t and W is the amount of DOX in DOX-loaded micelles.…”

Section: Methodsmentioning

confidence: 99%

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Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

Ghiarasim¹,

Tiron

et al. 2022

Nanomaterials

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Diblock copolymers of polyhistidine are known for their self-assembly into micelles and their pH-dependent disassembly due to the amphiphilic character of the copolymer and the unsaturated imidazole groups that undergo a hydrophobic-to-hydrophilic transition in an acidic pH. This property has been largely utilized for the design of drug delivery systems that target a tumor environment possessing a slightly lower extracellular pH (6.8–7.2). The main purpose of this study was to investigate the possibility of designed poly(ethylene glycol)-polyhistidine sequences synthesized using solid-phase peptide synthesis (SPPS), to self-assemble into micelles, to assess the ability of the corresponding micelles to be loaded with doxorubicin (DOX), and to investigate the drug release profile at pH values similar to a malignant extracellular environment. The designed and assembled free and DOX-loaded micelles were characterized from a physico-chemical point of view, their cytotoxicity was evaluated on a human breast cancer cell line (MDA-MB-231), while the cellular areas where micelles disassembled and released DOX were assessed using immunofluorescence. We concluded that the utilization of SPPS for the synthesis of the polyhistidine diblock copolymers yielded sequences that behaved similarly to the copolymeric sequences synthesized using ring-opening polymerization, while the advantages of SPPS may offer facile tuning of the histidine site or the attachment of a large variety of functional molecules.

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Section: Methodsmentioning

confidence: 99%

where W t is the amount of DOX released at time t and W is the amount of DOX in DOX-loaded micelles.…”

Section: Methodsmentioning

confidence: 99%

Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

Ghiarasim¹,

Tiron

et al. 2022

Nanomaterials

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“…Photodynamic and photothermal therapy is a light-responsive treatment method in which an injectable photosensitizer is activated by precise light irradiation and produces large quantities of reactive oxygen species (ROS) and thermal condition, which are harmful to tumor cells. Cheng's group 123 reported development of multifunctional light-triggered supramolecular micelles through A-functionalized oligomer polypropylene glycol (PPG), namely, A-PPG could coload antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within the micelles to achieve effective delivery combined with photochemotherapy. Due to the presence of hydrogen-bonded A-interactions within the micelles, the resulting micelles exhibited many unique physical properties, including tunable drug-loading properties, and longterm drug entrapment stability in serum-rich media.…”

Section: High Drug Loading Efficiencymentioning

confidence: 99%

Hydrogen-Bonding Interactions from Nucleobase-Decorated Supramolecular Polymer: Synthesis, Self-Assembly and Biomedical Applications

Ilhami,

Birhan,

Cheng

2023

ACS Biomater. Sci. Eng.

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The fabrication of supramolecular materials for biomedical applications such as drug delivery, bioimaging, wounddressing, adhesion materials, photodynamic/photothermal therapy, infection control (as antibacterial), etc. has grown tremendously, due to their unique properties, especially the formation of hydrogen bonding. Nevertheless, void space in the integration process, lack of feasibility in the construction of supramolecular materials of natural origin in living biological systems, potential toxicity, the need for complex synthesis protocols, and costly production process limits the actual application of nanomaterials for advanced biomedical applications. On the other hand, hydrogen bonding from nucleobases is one of the strategies that shed light on the blurred deployment of nanomaterials in medical applications, given the increasing reports of supramolecular polymers that promote advanced technologies. Herein, we review the extensive body of literature about supramolecular functional biomaterials based on nucleobase hydrogen bonding pertinent to different biomedical applications. It focuses on the fundamental understanding about the synthesis, nucleobase-decorated supramolecular architecture, and novel properties with special emphasis on the recent developments in the assembly of nanostructures via hydrogen-bonding interactions of nucleobase. Moreover, the challenges, plausible solutions, and prospects of the so-called hydrogen bonding interaction from nucleobase for the fabrication of functional biomaterials are outlined.

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“…Under light irradiation, ROS produced by the PS not only can be used for PDT, but also can cleave the TK linker to more rapidly or completely release the chemotherapeutic agent. Being an exogenous stimulus, light does not depend on the variation of tumor microenvironment and can be easily controlled in terms of wavelength, intensity, exposure area, and treatment duration to achieve spatiotemporal drug release (Figure 6) [68,69]. This synergistic approach was found to be particularly advantageous in the application of TK-based nanomedicines in cancer.…”

Section: Lightmentioning

confidence: 99%

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

et al. 2022

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Reactive oxygen species (ROS)-sensitive drug delivery systems (DDS) specifically responding to altered levels of ROS in the pathological microenvironment have emerged as an effective means to enhance the pharmaceutical efficacy of conventional nanomedicines, while simultaneously reducing side effects. In particular, the use of the biocompatible, biodegradable, and non-toxic ROS-responsive thioketal (TK) functional group in the design of smart DDS has grown exponentially in recent years. In the design of TK-based DDS, different technological uses of TK have been proposed to overcome the major limitations of conventional DDS counterparts including uncontrolled drug release and off-target effects. This review will focus on the different technological uses of TK-based biomaterials in smart nanomedicines by using it as a linker to connect a drug on the surface of nanoparticles, form prodrugs, as a core component of the DDS to directly control its structure, to control the opening of drug-releasing gates or to change the conformation of the nano-systems. A comprehensive view of the various uses of TK may allow researchers to exploit this reactive linker more consciously while designing nanomedicines to be more effective with improved disease-targeting ability, providing novel therapeutic opportunities in the treatment of many diseases.

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Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

Cited by 17 publications

References 57 publications

Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

Hydrogen-Bonding Interactions from Nucleobase-Decorated Supramolecular Polymer: Synthesis, Self-Assembly and Biomedical Applications

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

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