Photoacoustic and ultrasound dual-modality imaging of human peripheral joints

Xu, Guan; Rajian, Justin Rajesh; Girish, Gandikota; Kaplan, Mariana J.; Fowlkes, J. Brian; Carson, Paul L.; Wang, Xueding

doi:10.1117/1.jbo.18.1.010502

Cited by 80 publications

(59 citation statements)

References 16 publications

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“…Such advances would accelerate the clinical translation of PA imaging where clinically relevant ultrasound detection frequencies are used. In the past five years, several groups have employed the use of PA radiofrequency analysis to differentiate prostate adenocarcinoma tumors from normal tissue [31], detect the presence of red blood cell aggregation [30], [32], identify various stages of liver disease [29], [33] and characterize bone and joint microstructure in osteoporosis [34] and rheumatoid arthritis [35]. Theoretical models have also been developed for understanding the spectral features that arise from tissue microstructural changes [36], [37], [38], [39], [40], [41], [42].…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation

et al. 2017

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Frequency analysis of the photoacoustic radiofrequency signals and oxygen saturation estimates were used to monitor the in-vivo response of a novel, thermosensitive liposome treatment. The liposome encapsulated doxorubicin (HaT-DOX) releasing it rapidly (<20 s) when the tumor was exposed to mild hyperthermia (43 °C). Photoacoustic imaging (VevoLAZR, 750/850 nm, 40 MHz) of EMT-6 breast cancer tumors was performed 30 min pre- and post-treatment and up to 7 days post-treatment (at 2/5/24 h timepoints). HaT-DOX-treatment responders exhibited on average a 22% drop in oxygen saturation 2 h post-treatment and a decrease (45% at 750 nm and 73% at 850 nm) in the slope of the normalized PA frequency spectra. The spectral slope parameter correlated with treatment-induced hemorrhaging which increased the optical absorber effective size via interstitial red blood cell leakage. Combining frequency analysis and oxygen saturation estimates differentiated treatment responders from non-responders/control animals by probing the treatment-induced structural changes of blood vessel.

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Section: Introductionmentioning

confidence: 99%

Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation

et al. 2017

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“…Meanwhile, other laboratories worldwide are focusing on arthritis imaging with PAT. For instance, X. Wang and collaborators reported the PA images of a rat tail [22], human cadaver ngers, and recently a healthy human nger [23]. Ermilov et al has presented the large nger blood vessels of a human in three dimensions with its modi ed three-dimensional OA tomography (3D-OAT) system [24].…”

Section: Introductionmentioning

confidence: 97%

Thermoacoustic imaging of human finger joints and bones

Huang¹,

Qi²,

Zhao³

et al. 2015

X-Acoustics: Imaging and Sensing

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In this study, we explore a new application of thermoacoustic tomography (TAT) for imaging human nger joints and bones. Three volunteers' nger joints and bones were visualized with satisfying image contrast and spatial resolution by a TAT scanner. The recovered TAT images revealed apparent microwave absorption di erences between the joint cavity and bone. Beyond the full single nger imaging, a volunteer's four ngers were clearly and concurrently imaged. To con rm our observations, MRI images of two volunteers' ngers were performed, and the TAT recovered shape/size of the ngers were consistent with the MRI ndings. To further assess the feasibility of TAT for nger joint and bone imaging, we quantitatively calculated the conductivity of a case. This initial study suggests that TAT may be a good candidate for screening, diagnosing, and monitoring treatment of joint and bone diseases.

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“…However, it is difficult to obtain images of good quality because conventional linear array probe used in ultrasound devices has a limited angular view. Therefore, the photoacoustic imaging system which overcomes the limitation with a 2D array probe has been proposed [8] and studied in terms of real-time photoacoustic imaging techniques [9,10].…”

Section: Introductionmentioning

confidence: 99%

Real-time photoacoustic tomograpghy using linear array probe and detection of line structure using Hough transform

Shin

Park

Shin

et al. 2015

BME

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Abstract.A real-time photoacoustic tomography (PAT) system is developed using a linear array probe and phantom images are acquired with a pattern of line structure. Moreover, it is attempted to detect line structures from the acquired images by Hough transform. This effort leads to the measurement of a process of magenta passing through a tube and acquisition of images at a speed of about 2 frame/sec. Besides, it is confirmed that the Hough transform applied on the acquired PAT images has the detection rate of about 50% for delineating a line structure.

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Photoacoustic and ultrasound dual-modality imaging of human peripheral joints

Cited by 80 publications

References 16 publications

Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation

Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation

Thermoacoustic imaging of human finger joints and bones

Real-time photoacoustic tomograpghy using linear array probe and detection of line structure using Hough transform

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