Photoacoustic assessment of hemodynamic changes in foot vessels

Yang, Jinge; Zhang, Guang; Wu, Man; Shang, Qiquan; Huang, Lin; Jiang, Huabei

doi:10.1002/jbio.201900004

Cited by 27 publications

(23 citation statements)

References 53 publications

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“…Others vascular diagnostic imaging modalities, such as CTA, 70 nonenhanced MRA, 71,72 IVUS, 73 and the most recent emerging noninvasive US transducer array-based photoacoustic (optoacoustic) tomography (PTA), 74,75 are invoked to characterize anatomical details and morphologic characteristic of arterial lesion in diabetics lower limbs PAD. Generally, CTA and MRA are used in selected patients before revascularization to solve some specific questions caused by disagreement between previous imaging modalities and an existing particular clinical setting.…”

Section: Diagnostic Accuracymentioning

confidence: 99%

Ultrasound in the Modern Management of the Diabetic Foot Syndrome: A Multipurpose Versatile Toolkit

Pieruzzi

Napoli

Goretti

et al. 2020

The International Journal of Lower Extremity Wounds

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Ultrasound (US) is a noninvasive and versatile technology that in recent years found acceptance in almost all the medical specialties, with diagnostic and interventional applications. In the diabetic foot syndrome (DFS), US found specific indications mainly in the screening, quantification, and follow-up of the vascular component of the pathology, but also in the study of the deformities and structural modifications induced by neuropathy and in the diagnosis and surgical management of infections, especially those that induce anatomical changes, like abscesses and fasciitis. This review will summarize all these application of US, giving special attention to the vascular aspects, and on the predominant role that US gained in recent times to guide the indication to revascularization, on the new standardized approach to the study of the arterial tree of the limb and the foot, the so-called duplex ultrasound arterial mapping, which significantly increased the utilization of US to plan the revascularizations in this complex pathology. Outside the vascular fields, the diagnosis of neuropathy and infection and the intraoperative use of US in the surgical management of abscesses and fasciitis will be discussed, leaving the last part to the new and interesting applications of US in the management of DFU, a field that is still in evolution, offering new possibilities to the health care professionals involved in the management of these chronic wounds. The variety of applications both in diagnostic and operative fields makes US a rather versatile technology—a toolkit—that should have a special place among those at reach of the specialists of DFS care.

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Section: Diagnostic Accuracymentioning

confidence: 99%

Ultrasound in the Modern Management of the Diabetic Foot Syndrome: A Multipurpose Versatile Toolkit

Pieruzzi

Napoli

Goretti

et al. 2020

The International Journal of Lower Extremity Wounds

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“…This type of study is feasible in humans. 22,28,29 A potential limitation of PAI is the depth penetration. Although imaging depth depends on optical and acoustic values of the tissue and can vary greatly, 22 depth penetration of 5 to 7 cm can be achieved and should be adequate for imaging calf muscles in humans.…”

Section: Discussionmentioning

confidence: 99%

“…21,22 The PAI technique has widely been used over the past decade for noninvasive cancer detection, diagnosis, and staging, [23][24][25] but its ability to monitor limb oxygenation and vascular dysfunction by peripheral arteries is in its infancy. [26][27][28][29] The goal of this study is to investigate the potential of PAI for evaluating oxygenation changes associated with PAD. As age is an independent unmodifiable risk factor, the study is performed in mice from different age cohorts to determine the differences in limb oxygenation with age.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Age-related Oxygenation Changes in Calf Skeletal Muscle by Photoacoustic Imaging: A Potential Tool for Peripheral Arterial Disease

et al. 2019

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Peripheral artery disease is often asymptomatic, and various imaging and nonimaging techniques have been used for assessment and monitoring treatments. This study is designed to demonstrate the ability of photoacoustic imaging to noninvasively determine changes in tissue oxygenation that occur in mice’s hind limb skeletal muscle as they age. Mice from two age cohorts were scanned bilaterally with a pulsed laser. The photoacoustic signal was unmixed to generate a parametric map of estimated oxygen saturation and then overlaid on grayscale ultrasound images. Tissue oxygenation measured in young and old mice was compared. Photoacoustic imaging visually and quantitatively showed the decrease in skeletal muscle oxygenation that occurs with age. Percent tissue oxygenation decreased from 30.2% to 3.5% ( p < 0.05). This reduction corresponded to reduced fractional area of oxygenation, which decreased from 60.6% to 6.0% ( p < 0.05). The change in oxygenation capacity of the still active vascular regions was insignificant ( p > 0.05). Intrasubject, intra-, and interobserver comparisons showed low variability in measurements, exhibited by high regression and intraclass correlations exceeding 0.81 for all ages. The decrease in oxygenation detected by photoacoustic imaging paralleled the known oxygenation decrease observed in aging tissues, demonstrating that photoacoustic imaging can assess age-related changes in a mouse calf muscle. These intramuscular changes could potentially act as a strong diagnostic marker for peripheral artery disease. This study thus opens the doors for a novel, affordable, noninvasive method of evaluation free of radiation or exogenous material.

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“…At the moment, only a few examples of in vivo studies are conducted in the field of diabetes using PAT. In the work of Yang et al [201] it was shown that PAT has a potential in the diagnosis of vascular function (on the example of changes arising from arterial and venous occlusion).…”

Section: Optical Approaches In Diagnosticsmentioning

confidence: 99%

Biophotonics methods for functional monitoring of complications of diabetes mellitus

Zharkikh

Dremin

Zherebtsov

et al. 2020

Journal of Biophotonics

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The prevalence of diabetes complications is a significant public health problem with a considerable economic cost. Thus, the timely diagnosis of complications and prevention of their development will contribute to increasing the length and quality of patient life, and reducing the economic costs of their treatment. This article aims to review the current state-of-the-art biophotonics technologies used to identify the complications of diabetes mellitus and assess the quality of their treatment. Additionally, these technologies assess the structural and functional properties of biological tissues, and they include capillaroscopy, laser Doppler flowmetry and hyperspectral imaging, laser speckle contrast imaging, diffuse reflectance spectroscopy and imaging, fluorescence spectroscopy and imaging, optical coherence tomography, optoacoustic imaging and confocal microscopy. Recent advances in the field of optical noninvasive diagnosis suggest a wider introduction of biophotonics technologies into clinical practice and, in particular, in diabetes care units.

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Photoacoustic assessment of hemodynamic changes in foot vessels

Cited by 27 publications

References 53 publications

Ultrasound in the Modern Management of the Diabetic Foot Syndrome: A Multipurpose Versatile Toolkit

Ultrasound in the Modern Management of the Diabetic Foot Syndrome: A Multipurpose Versatile Toolkit

Assessment of Age-related Oxygenation Changes in Calf Skeletal Muscle by Photoacoustic Imaging: A Potential Tool for Peripheral Arterial Disease

Biophotonics methods for functional monitoring of complications of diabetes mellitus

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