Photoacoustic‐Enabled Self‐Guidance in Magnetic‐Hyperthermia Fe@Fe₃O₄ Nanoparticles for Theranostics In Vivo

Abstract

Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe O nanoparticles (RGD-PEG-MNPs) are developed for photoacoustic (PA)-enabled self-guidance in tumor-targeting magnetic hyperthermia therapy in vivo. In the α β -positive U87MG glioblastoma xenograft model, the PA signal of RGD-PEG-MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2-folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD-PEG-MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD-PEG-MNPs.

Amplified Photoacoustic Imaging of Tumor through In Situ Cycloaddition

“…The PA imaging in tumor was monitored after the intravenous injection for the different time ( Figure ). For the pretargeting group, Fe@Fe 3 O 4 /DBCO NPs were accumulated in tumor through the EPR effect . The intensity of PA signal in tumor reached a maximum after 10 h injection, which was only ≈1.5 times higher than that before the injection.…”

Hyperthermia treatment advances for brain tumors

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Sub-10 nm Cu₅FeS₄ cube for magnetic resonance imaging-guided photothermal therapy of cancer

“…According to the previous study, 42 1-dodecanethiol-coated Cu 5 FeS 4 cube in chloroform (0.5 mL, 10 mg/mL) was added to DSPE-PEG2000 (10 mg in 2 mL of chloroform) in a glass vial and shaken for overnight. After removing the solvent completely, 5 mL of water was added.…”

“…Thus, DSPE-PEG2000 was used to modify the Cu 5 FeS 4 cube according to the previous method. 42 The amphiphilic DSPE-PEG2000 can transform the hydrophobic nanoparticles to hydrophilic nanoparticles through the hydrophobic effect ( Figure 3A). The dispersion stability of the nanocrystals in water was evaluated by the absorbance at 808 nm of the Cu 5 FeS 4 cube dispersed in water after modification with time going.…”