Photoacoustic evaluation of human inflammatory arthritis in human joints

Jo, Janggun; Xu, Guan; Marquardt, April; Girish, Gandikota; Wang, Xueding

doi:10.1117/12.2252342

Cited by 5 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar clinical study for identifying inflammatory arthritis in human joints was reported by Jo et al [32]. Focusing on the capability of PA imaging for evaluating hemodynamic changes, metacarpophalangeal (MCP) joints were imaged with a PA/US dual imaging system using two excitation wavelengths, 576 and 584 nm for oxy-and deoxy-hemoglobin, respectively.…”

Section: Clinical Pai Systems Based On Linear Array Transducersmentioning

confidence: 87%

“…Not only because of its general use in clinical practice but also because of its suitability for conventional ultrasound and photoacoustic dual-modal imaging, linear array transducer is also the most commonly used transducer for clinical PA platforms, and the first CEapproved PAI product supports linear array transducer (Imagio, Seno Medical Instruments Inc., San Antonio, TX, USA). In this section, we will present a review of several PA imaging platforms with linear array transducer for various clinical applications such as breast cancer [53,54], thyroid cancer [46,55], vascular examination [30,56], and inflammation [31,32]. Many research groups are working on clinical PA imaging systems to image intrinsic optical contrasts (e.g., oxy-hemoglobin, deoxy-hemoglobin, melanin, lipid, water, etc.)…”

Section: Clinical Pai Systems Based On Linear Array Transducersmentioning

confidence: 99%

“…A commercial research US platform (V1, Verasonics) and a tunable dye laser (ND6000, Continuum) pumped by the second harmonic of an Nd:YAG laser (Powerlite, Continuum) were integrated to build the PAI system [62,63]. A custom-design probe holder integrated a linear array transducer (CL15-7, [31,32]. PA photoacoustic, US ultrasound, sO 2 oxygen saturation, MCP metacarpophalangeal Philips) and an optical fiber bundle (CeramOptec Industries Inc.) into one body as shown in Fig.…”

Section: Clinical Pai Systems Based On Linear Array Transducersmentioning

confidence: 99%

“…Since hemoglobin has different optical absorbance coefficients depending on whether it is bound or unbound to oxygen, PAI can give the oxygen saturation level of blood vessels by using multiple wavelengths [22]. Since tumors [23][24][25][26][27][28], vascular diseases [29,30], and arthritis [31,32] are known to cause abnormal changes in the surrounding microenvironment, such as neovascularization [33,34], hypoxia [35], or ischemia [36], PAI is very useful for diagnosing them. Thirdly, since PAI is inherently compatible with US imaging, it provides anatomical information of the underlying tissue simultaneously with the PAI image for the better diagnosis of the underlying disease [37].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical photoacoustic imaging platforms

et al. 2018

View full text Add to dashboard Cite

Photoacoustic imaging (PAI) is a new promising medical imaging technology available for diagnosing and assessing various pathologies. PAI complements existing imaging modalities by providing information not currently available for diagnosing, e.g., oxygenation level of the underlying tissue. Currently, researchers are translating PAI from benchside to bedside to make unique clinical advantages of PAI available for patient care. The requirements for a successful clinical PAI system are; deeper imaging depth, wider field of view, and faster scan time than the laboratory-level PAI systems. Currently, many research groups and companies are developing novel technologies for data acquisition/signal processing systems, detector geometry, and an acoustic sensor. In this review, we summarize state-of-the-art clinical PAI systems with three types of the imaging transducers: linear array transducer, curved linear array transducer, and volumetric array transducer. We will also discuss the limitations of the current PAI systems and describe latest techniques being developed to address these for further enhancing the image quality of PAI for successful clinical translation.

show abstract

Section: Clinical Pai Systems Based On Linear Array Transducersmentioning

confidence: 87%

Section: Clinical Pai Systems Based On Linear Array Transducersmentioning

confidence: 99%

Section: Clinical Pai Systems Based On Linear Array Transducersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical photoacoustic imaging platforms

et al. 2018

View full text Add to dashboard Cite

show abstract

“…PAI has also been investigated in pre-clinical studies of synovitis [28] , [29] , [30] , [31] , and several setups have been proposed for human finger joints [32] , [33] , [34] , [35] , [36] , [37] . In addition, a few early feasibility studies have been performed with RA patients [38] , [39] . However, these studies used large lasers, not suited for routine clinical application, let alone point-of-care imaging.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system

Berg

Daoudi²,

Moens

et al. 2017

Photoacoustics

View full text Add to dashboard Cite

We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed. We quantified the amount of photoacoustic (PA) signal using a region of interest (ROI) drawn over the hypertrophic joint space. PAI response was increased 4 to 10 fold when comparing inflamed with contralateral non-inflamed joints and with joints from healthy volunteers (p < 0.001 for both). US-PD and PAI were strongly correlated (Spearman’s ρ = 0.64, with 95% CI: 0.42, 0.79). Hence, PAI using a compact handheld probe is capable of detecting clinically evident synovitis. This motivates further investigation into the predictive value of PAI, including multispectral PAI, with other established modalities such as US-PD or MRI.

show abstract

Spectroscopic photoacoustic imaging of cartilage damage

Teeffelen

Ito

et al. 2021

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Photoacoustic evaluation of human inflammatory arthritis in human joints

Cited by 5 publications

References 25 publications

Clinical photoacoustic imaging platforms

Clinical photoacoustic imaging platforms

Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system

Spectroscopic photoacoustic imaging of cartilage damage

Contact Info

Product

Resources

About