Photoacoustic-guided convergence of light through optically diffusive media

Kong, Fanting; Silverman, Ronald H.; Liu, Liping; Chitnis, Parag V.; Lee, Kotik K.; Chen, Ying-Chih

doi:10.1364/ol.36.002053

Cited by 95 publications

(66 citation statements)

References 8 publications

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“…The use of PA for wavefront shaping was pioneered by Kong et al [61]. Chaigne et al [62] extended the method to use the full 3-D photoacoustic reconstruction in order to measure a complete TM for at any arbitrary point in an absorbing structure.…”

Section: Photoacoustic Feedbackmentioning

confidence: 99%

“…Especially the new anisotropic memory effect [85] opens new possibilities for deep tissue imaging. Finally, new feedback mechanisms are being explored that allow focusing light at arbitrary locations inside scattering tissue [57,61,62,64]. Even though these methods are currently too slow for in-vivo imaging, there is still plenty of room for improvement both through engineering and through a better understanding of the physics of scattered light and sound/light interaction.…”

Section: Applications and Outlookmentioning

confidence: 99%

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Feedback-based wavefront shaping

Vellekoop¹

2015

Opt. Express

374

269

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Light scattering was thought to be the fundamental limitation for the depth at which optical imaging methods can retain their resolution and sensitivity. However, it was shown that light can be focused inside even the most strongly scattering objects by spatially shaping the wavefront of the incident light. This review summarizes recently developed feedback-based approaches for focusing light inside and through scattering objects.

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Section: Photoacoustic Feedbackmentioning

confidence: 99%

Section: Applications and Outlookmentioning

confidence: 99%

Feedback-based wavefront shaping

Vellekoop¹

2015

Opt. Express

374

269

View full text Add to dashboard Cite

show abstract

“…In many imaging scenarios, however, there is no direct access to the target plane. In those cases, nonlinear 6 , fluorescent 7 , kinematic 8,9 , acoustooptic [10][11][12] and photo-acoustic [13][14][15] guide stars can be used as reference beacons. However, these techniques provide wavefront information for only one target location at a time.…”

mentioning

confidence: 99%

Translation correlations in anisotropically scattering media

et al. 2015

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Controlling light propagation across scattering media by wavefront shaping holds great promise for a wide range of communications and imaging applications. However, finding the right wavefront to shape is a challenge when the mapping between input and output scattered wavefronts (i.e. the transmission matrix) is not known. Correlations in transmission matrices, especially the so-called memory-effect, have been exploited to address this limitation. However, the traditional memory-effect applies to thin scattering layers at a distance from the target, which precludes its use within thick scattering media, such as fog and biological tissue. Here, we theoretically predict and experimentally verify new transmission matrix correlations within thick anisotropically scattering media, with important implications for biomedical imaging and adaptive optics.

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“…Therefore, it can potentially serve as a nearly perfect noninvasive guidestar. The idea of photoacoustically guided wavefront shaping (PAWS) was first proposed in 2011 by Kong et al, 86 which has rapidly gained attention and has been followed by several other research groups. [87][88][89][90][91] Using the amplitude of photoacoustic signals as feedback for optimization algorithms that control the updating of the wavefront compensation patterns on the SLM, optical energy within the ultrasonic focus gradually increases with the growth of the feedback signal.…”

Section: A Optical Focusing Through Pre-compensated Wavefront Shapingmentioning

confidence: 99%

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Park

Lee

et al. 2018

APL Photonics

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Multiple light scattering has been regarded as a barrier in imaging through complex media such as biological tissues. Owing to recent advances in wavefront shaping techniques, optical imaging through intact biological tissues without invasive procedures can now be used for direct experimental studies, presenting promising application opportunities in in vivo imaging and diagnosis. Although most of the recent proof of principle breakthroughs have been achieved in the laboratory setting with specialties in physics and engineering, we anticipate that these technologies can be translated to biological laboratories and clinical settings, which will revolutionize how we diagnose and treat a disease. To provide insight into the physical principle that enables the control of multiple light scattering in biological tissues and how recently developed techniques can improve bioimaging through thick tissues, we summarize recent progress on wavefront shaping techniques for controlling multiple light scattering in biological tissues.

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Photoacoustic-guided convergence of light through optically diffusive media

Cited by 95 publications

References 8 publications

Feedback-based wavefront shaping

Feedback-based wavefront shaping

Translation correlations in anisotropically scattering media

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

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