Photoacoustic-guided endovenous laser ablation: Characterization and in vivo canine study

Abstract

Endovenous laser ablation (EVLA) is a minimally invasive surgical procedure, often guided by ultrasound (US) imaging, for treating venous insufficiencies. US imaging limitations in accurately visualizing the catheter and the lack of a temperature monitoring system can lead to sub-optimal outcomes. An integrated photoacoustic (PA)-guided EVLA system has been previously developed and reported to overcome the shortcomings of US-guided procedure. In this study, we further characterized the system and tested the in vivo utility. In addition, PA thermometry was further explored by compensating the variation of PA signal with temperature with respect to the temperature-dependent absorption of blood and water. In vivo imaging results indicated that the PA-guided EVLA system can provide high contrast and accurate images of the ablation catheter tip overlaid on US images of the background tissue. Additionally, absorption-compensated PA signal amplitudes over a relevant range of temperature were measured and demonstrated.

Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

“…19,152,217 5.4 Photoacoustic-Guided Surgical Navigation PA-guided intervention is a growing research field that is described in several reviews. [218][219][220] Preclinical studies have demonstrated the feasibility of various applications, such as pedicle screw evaluation, 221 catheter-based interventions, 222,223 and liver surgery. 224 In cardiac, catheter-based interventions accurate navigation is essential for diagnosis and effective treatment.…”

“…PA-guided intervention is a growing research field that is described in several reviews. 218 – 220 Preclinical studies have demonstrated the feasibility of various applications, such as pedicle screw evaluation, 221 catheter-based interventions, 222 , 223 and liver surgery. 224 …”

In vivo photothermal therapy monitored by multi-position calibrated photoacoustic thermometer

“…The output of PA thermometer was used as the feed-back controller for photothermal therapy [27] . An integrated photoacoustic guided system was developed for endovenous laser ablation [28] .…”

Visualization of photothermal therapy by semiconducting polymer dots mediated photoacoustic detection in NIR II

“…Therefore, the concept of PA thermometry was developed rstly by Rinat et al in 2005 [20]. Subsequently, PA thermometry has become a valuable feedback modality in the different thermal treatment processes, especially in laser radiation [21][22][23][24]. However, PA signals of the tissue itself are very weak for the low absorption coe cient and are easily affected by noise.…”