Photoacoustic Imaging as a Tool for Assessing Hair Follicular Organization

Hariri, Ali; Moore, Colman; Mantri, Yash; Jokerst, Jesse V.

doi:10.3390/s20205848

Cited by 14 publications

(7 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PA imaging is ideally suited to monitor local angiogenesis, perfusion and oxygen saturation: These are all key parameters for wound healing 44 . Multiple studies have shown the use of PA tomography and microscopy to visualise the skin surface, superficial blood vessels and blood flow with exceptional spatial resolution (<100 μm, lateral resolution) 21,45–48 . The LED‐based PA system used in this study has much lower spatial resolution and fluence but is also less expensive and more robust/portable compared to conventional high energy laser‐based systems.…”

Section: Discussionmentioning

confidence: 99%

Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds

Mantri

Tsujimoto

Donovan

et al. 2022

Wound Repair Regeneration

Self Cite

View full text Add to dashboard Cite

Chronic wounds are a major health problem that cause the medical infrastructure billions of dollars every year. Chronic wounds are often difficult to heal and cause significant discomfort. Although wound specialists have numerous therapeutic modalities at their disposal, tools that could three dimensional‐map wound bed physiology and guide therapy do not exist. Visual cues are the current standard but are limited to surface assessment; clinicians rely on experience to predict response to therapy. Photoacoustic (PA) ultrasound (US) is a non‐invasive, hybrid imaging modality that can solve these major limitations. PA relies on the contrast generated by haemoglobin in blood which allows it to map local angiogenesis, tissue perfusion and oxygen saturation—all critical parameters for wound healing. This work evaluates the use of PA‐US to monitor angiogenesis and stratify patients responding versus not‐responding to therapy. We imaged 19 patients with 22 wounds once a week for at least 3 weeks. Our findings suggest that PA imaging directly visualises angiogenesis. Patients responding to therapy showed clear signs of angiogenesis and an increased rate of PA increase (p = 0.002). These responders had a significant and negative correlation between PA intensity and wound size. Hypertension was correlated to impaired angiogenesis in non‐responsive patients. The rate of PA increase and hence the rate of angiogenesis was able to predict healing times within 30 days from the start of monitoring (power = 88%, alpha = 0.05). This early response detection system could help inform management and treatment strategies while improving outcomes and reducing costs.

show abstract

Section: Discussionmentioning

confidence: 99%

Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds

Mantri

Tsujimoto

Donovan

et al. 2022

Wound Repair Regeneration

Self Cite

View full text Add to dashboard Cite

show abstract

“…PA imaging is ideally suited to monitor local angiogenesis, perfusion, and oxygen saturation: These are all key parameters for wound healing. (44) Multiple studies have shown the use of PA tomography and microscopy to visualize the skin surface, superficial blood vessels, and blood flow with exceptional spatial resolution (< 100 µm, lateral resolution) (21,(45)(46)(47)(48) The LED-based PA system used in this study has much lower spatial resolution and fluence but is also less expensive and more robust/portable compared to conventional high energy laser-based systems.…”

Section: Imaging Parametersmentioning

confidence: 99%

Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds

Mantri

Tsujimoto

Donovan

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Chronic wounds are a major health problem that cause the medical infrastructure billions of dollars every year. Chronic wounds are often difficult to heal and cause significant discomfort. Although wound specialists have numerous therapeutic modalities at their disposal, tools that could 3D-map wound bed physiology and guide therapy do not exist. Visual cues are the current standard but are limited to surface assessment; clinicians rely on experience to predict response to therapy. Photoacoustic (PA) ultrasound (US) is a non-invasive, hybrid imaging modality that can solve these major limitations. PA relies on the contrast generated by hemoglobin in blood which allows it to map local angiogenesis, tissue perfusion and oxygen saturation - all critical parameters for wound healing. This work evaluates the use of PA-US to monitor angiogenesis and stratify patients responding vs. not-responding to therapy. We imaged 19 patients with 22 wounds once a week for at least three weeks. Our findings suggest that PA imaging directly visualizes angiogenesis. Patients responding to therapy showed clear signs of angiogenesis and an increased rate of PA increase (p = 0.002). These responders had a significant and negative correlation between PA intensity and wound size. Hypertension was correlated to impaired angiogenesis in non-responsive patients. The rate of PA increase and hence the rate of angiogenesis was able to predict healing times within 30 days from the start of monitoring (power = 88%, alpha = 0.05) This early response detection system could help inform management and treatment strategies while improving outcomes and reducing costs.

show abstract

“…In both cases, it is important for clinicians to characterize follicle density for treatment planning and evaluation. Hariri et al utilized 2D and 3D LED-based PA imaging for measuring follicle density and angles across regions of varying density [ 14 ]. The authors validated the idea using experiments on small animals and also using measurements on healthy human volunteers.…”

Section: Original Papers—full-length Articles Communications Andmentioning

confidence: 99%