Photoacoustic imaging of voltage responses beyond the optical diffusion limit

Rao, Bin; Zhang, Ruiying; Li, Lei; Shao, Jin-Yu; Wang, Lihong V.

doi:10.1038/s41598-017-02458-w

Cited by 57 publications

(45 citation statements)

References 56 publications

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“…The above phenomenon proved that PA imaging can be employed not only observe brain damage and recovery but also to trace stem cells within the pathological region. In recent years, more examples have demonstrated the feasibility for brain PA imaging …”

Section: Biomedical Applicationsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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“…Although the current platform has been demonstrated in small animals, human clinical translations may require tens of centimeters of tissue penetration. PACT can provide up to 7-cm tissue penetration, which is limited by photon dissipation [21,33]. By employing a more penetrating excitation source-microwave and acoustic detection, thermoacoustic tomography (TAT) promises tissue penetration for clinical translations [34].…”

Section: Discussionmentioning

confidence: 99%

Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo

Yang

et al. 2020

Photons Plus Ultrasound: Imaging and Sensing 2020

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Tremendous progress in synthetic micro/nanomotors has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient for deep tissue imaging and motion control in vivo. Here, we present a photoacoustic computed tomography (PACT) guided investigation of micromotors in intestines in vivo. The micromotors enveloped in microcapsules exhibit efficient propulsion in various biofluids once released. PACT has visualized the migration of micromotor capsules toward the targeted regions in real time in vivo. The integration of the developed microrobotic system and PACT enables deep imaging and precise control of the micromotors in vivo.

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“…Moreover, a compact system volume in PA imaging may extend its scientific efficacy. For example, it may enable an implantable and/or wearable PA neurosensing system for continuous monitoring, leading to successful translations of current neuroscientific findings and neuro-engineering innovations into practice [24][25][26][27][28][29][30][31][32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

A Pseudo-Dynamic Delay Calculation Using Optimal Zone Segmentation for Ultra-Compact Ultrasound Imaging Systems

2019

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The implementation of dynamic delay calculations (DDCs) is challenging for ultra-compact ultrasound imaging due to the enormous computation and power consumption requirements. Here, we present an efficient pseudo-DDC method based on optimal zone segmentation (PDC-Optimal), which significantly decreases these requirements relative to an unconstrained DDC method: reductions in flip-flops of 84.35% and in look-up tables of 94.19%, respectively. The reductions lead to an up to 94.53% lower dynamic power consumption and provide image quality comparable to the unconstrained DDC method. The proposed PDC-Optimal method also provides adaptive flexibility between beamforming accuracy and battery life using the delay error allowance, a user-definable parameter. A conventional pseudo-DDC method using uniform zone segmentation (PDC-Conv) presented substantial image degradation in the near imaging field when the same number of zone segments was used. Therefore, the PDC-Optimal method provides an efficient yet flexible DDC solution to improve the experiences for ultra-compact ultrasound imaging system users.

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Photoacoustic imaging of voltage responses beyond the optical diffusion limit

Cited by 57 publications

References 56 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo

A Pseudo-Dynamic Delay Calculation Using Optimal Zone Segmentation for Ultra-Compact Ultrasound Imaging Systems

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