Photoacoustic investigation of a neonatal skull phantom

Volinski, Bridget; Hariri, Ali; Fatima, Afreen; Xu, Qiuyun; Avanaki, Kamran

doi:10.1117/12.2254495

Cited by 9 publications

(8 citation statements)

References 13 publications

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“…The figure shows that when the same total optical energy is deposited to the tissue, the penetration depth is greater for the multi-angle illumination than for full-field illumination. The method introduced in this study maybe used for PA transcranial imaging where skull has an aberration effect on the PA signals [33][34][35][36][37][38][39][40].…”

Section: Resultsmentioning

confidence: 99%

Adjustable light illumination for linear array photoacoustic computed tomography

Manwar¹,

Benavides²,

Prakash³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Photoacoustic computed tomography (PACT) utilizing a linear array ultrasound transducer that can be handheld is popular in clinical translation. However, in linear array PACT, one of the challenges is achieving homogenous light illumination of structures from the surface through deep structures within biological tissue with limited optical energy. A circular or rectangular optical fiber bundle attached to both sides of the elevation plane of the transducer at a fixed angle provides light delivery in linear array PACT, but this configuration does not provide optimum homogenous illumination. Therefore, it is essential to have accessibility to angular adjustment of the optical beam path to allow photons to create different pathways. Existing methods for implementing various beam paths are not flexible or require precise calibration for any changes in the angle of illumination. In this study, we propose a simple and effective adjustable-angle illumination scheme for linear array-based PACT to create different illumination focal points randomly within the imaging plane. This method, based on an adjustable angular illumination technique while acquiring photoacoustic signals, allows the incident photons to interact with the imaging targets for longer periods of time and diffuse further in all directions. We have investigated the effectiveness of the proposed method by imaging photoacoustic targets in biological tissues ex-vivo and demonstrated that deeper structures can be successfully identified.

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Section: Resultsmentioning

confidence: 99%

Adjustable light illumination for linear array photoacoustic computed tomography

Manwar¹,

Benavides²,

Prakash³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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“…There have been several attempts to find the most reliable wavelength for deep PA imaging. Some of these findings can be found in [ 199 , [220] , [221] , [222] , [223] ]. Another challenge is the detection of ultrasound signals through the skull.…”

Section: Neuroimaging Modalities For Measuring Resting-state Functionmentioning

confidence: 99%

Neonatal brain resting-state functional connectivity imaging modalities

Mohammadi‐Nejad¹,

Mahmoudzadeh²,

Hassanpour³

et al. 2018

Photoacoustics

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Infancy is the most critical period in human brain development. Studies demonstrate that subtle brain abnormalities during this state of life may greatly affect the developmental processes of the newborn infants. One of the rapidly developing methods for early characterization of abnormal brain development is functional connectivity of the brain at rest. While the majority of resting-state studies have been conducted using magnetic resonance imaging (MRI), there is clear evidence that resting-state functional connectivity (rs-FC) can also be evaluated using other imaging modalities. The aim of this review is to compare the advantages and limitations of different modalities used for the mapping of infants’ brain functional connectivity at rest. In addition, we introduce photoacoustic tomography, a novel functional neuroimaging modality, as a complementary modality for functional mapping of infants’ brain.

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“…Neonatal humans [23], tiny animals [19], and volumetric mammography [24,25] have all been investigated using 3D-PACT. There have been some effort on 3D transcranial photoacoustic imaging however the skull aberration has been a limitation factor as shown by us and many other groups [23,[26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Transducer misplacement compensation for in-lab-made 3D photoacoustic tomography systems using nature-inspired algorithms

Rahaman¹,

Prakash

Ranjbaran

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Three-dimensional (3D) photoacoustic tomography is a method of choice for imaging round organs such as brain and breast. Many research groups have used a fully populated hemispherical transducer array with 256, 512, 1028, or 2048 elements and used that for 3D imaging. These transducer arrays are expensive and require a sophisticated data acquisition unit. Other groups have used much smaller number of transducers with a rotating mechanism which eventually filled out the entire hemisphere. We have built a 3D hemispherical array with 28 transducers which are placed on a 3D printed dome-like unit. The location of transducers however may be off-placed by a few millimeters (due to human error and errors in 3D printing). This may be to defocus the reconstructed image if the acceptable positions of transducers are not selected. In this work, we developed a compensation algorithm for misplacement of these transducers using Cuckoo search (CS) algorithm. The CS algorithm finds the optimum location for the transducers using levy flight which relies on levy distribution. The optimum location of each of these transducers is found within -4 mm to 4 mm of their locations. Universal back projection algorithm was used for image reconstruction and the sharpness of 3D image was used as the cost function; additionally, two more objective functions, the Brenner gradient, and the Tenenbaum gradient was investigated.

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Photoacoustic investigation of a neonatal skull phantom

Cited by 9 publications

References 13 publications

Adjustable light illumination for linear array photoacoustic computed tomography

Adjustable light illumination for linear array photoacoustic computed tomography

Neonatal brain resting-state functional connectivity imaging modalities

Transducer misplacement compensation for in-lab-made 3D photoacoustic tomography systems using nature-inspired algorithms

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