Photoacoustic methods for in vitro study of kinetics progesterone release from the biodegradation of polyhydroxybutyrate/polycaprolactone used as intravaginal devices

Abstract

Intravaginal devices composed of polyhydroxybutyrate/polycaprolactone blends incorporating progesterone were used over eight days in crossbred cow ovariectomized, and then analyzed with photoacoustic methods, measuring the absorption spectra, thermal diffusivity, and inspecting its degradation by means of scanning electron microscopy. The characteristic time found for progesterone release was TR ∼ 53 h, and the typical time found for biodegradation was TB ∼ 30 h. Morphological analysis complements the study showing that release of progesterone and biodegradation of the blend occurs on sample surface.

Biodegradable Polymers in Veterinary Medicine—A Review

“…Bovine tuberculosis is one of a major health problem in cattle and development of an effective vaccine to control this disease is of great importance. PHB nanoparticles which displayed mycobacterial antigens on the surface of the bio-beads were successfully tried for this purpose, showing the potential of this approach to produce cost-effective vaccines to combat tuberculosis or other diseases in animals [ 213 ].…”