Photoacoustic Multispectral Elastography Based on the Photoacoustic Oscillation Effect for Microelastomers in Deep Tissue

Liu, Yang; Tao, Chao; Liu, Xiaojun

doi:10.1103/physrevapplied.20.024035

Phys. Rev. Applied

2023

DOI: 10.1103/physrevapplied.20.024035

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Photoacoustic Multispectral Elastography Based on the Photoacoustic Oscillation Effect for Microelastomers in Deep Tissue

Yang Liu

Chao Tao

Xiaojun Liu

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Cited by 5 publications

References 55 publications

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Optical‐resolution photoacoustic microelastography system for elasticity mapping: Phantom study and practical application

Wan,

Zhang,

et al. 2024

Journal of Biophotonics

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Elastography is a noninvasive technique for characterizing the mechanical properties of biological tissues. Conventional methods have limitations in resolution and sensitivity, hindering disease detection in clinical diagnostics. To address these issues, this study developed an optical‐resolution photoacoustic microelastography (OR‐PAME) system. Using an agar tissue phantom with varying agar concentrations and contrast agents, PAME evaluated elasticity distribution under compression in both lateral and axial dimensions. It indirectly measured elastic properties by correlating photoacoustic responses, temporal lags, and induced displacement. We also applied the system to the study of the distribution of elastic characteristics of the liver tissue after ablation, which confirmed the potential of OR‐PAME in the study of elastic characteristics. Quantitative analysis showed greater lateral displacement in regions with reduced agar concentrations, indicating decreased stiffness. PAME also detected vertical displacement along the axial plane, validating its efficacy in elastographic imaging. By improving resolution and penetration, PAME provides superior visualization of elasticity distribution. Its methodology correlates microstructural alterations with tissue biomechanics, holding potential implications in medical diagnostics.

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Optical‐resolution photoacoustic microelastography system for elasticity mapping: Phantom study and practical application

Wan,

Zhang,

et al. 2024

Journal of Biophotonics

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Monitoring of microvascular calcification by time-resolved photoacoustic microscopy

Ma,

Yu,

Zhu

et al. 2025

Photoacoustics

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Wavelet-based photoacoustic viscoelastographic microscopy using photoacoustic damped oscillation effect

Liu,

Zou,

Wang

et al. 2024

Applied Physics Letters

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Viscoelastic characterization of biological tissue has significant biomedical value. In this study, we propose a wavelet-based photoacoustic viscoelastographic microscopy to characterize the viscoelasticity of tissues beneath the optical scattering depth from photoacoustic oscillation signals. Irradiated by laser pulses, biological tissue absorbs energy, expands, continues oscillating, and emits damped transient ultrasonic waves, i.e., photoacoustic oscillation signals, for a short time. A damped oscillation wavelet is applied to map photoacoustic oscillation signals into a representation of time, frequency, and decay rate. We can evaluate the frequency and decay rate of the photoacoustic oscillation signals. By considering the interrelationships among frequency, decay rate, shear modulus, and shear viscosity coefficient, we can generate images that depict the shear modulus image and shear viscosity coefficient image within the tissue. These images of the shear modulus and shear viscosity coefficient collectively form the viscoelastogram of the tissue, offering a comprehensive portrayal of its viscoelastic properties. Our study has potential biomedical value and may improve the accurate diagnosis of diseases and achieve more effective early interventions.

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Photoacoustic Multispectral Elastography Based on the Photoacoustic Oscillation Effect for Microelastomers in Deep Tissue

Cited by 5 publications

References 55 publications

Optical‐resolution photoacoustic microelastography system for elasticity mapping: Phantom study and practical application

Optical‐resolution photoacoustic microelastography system for elasticity mapping: Phantom study and practical application

Monitoring of microvascular calcification by time-resolved photoacoustic microscopy

Wavelet-based photoacoustic viscoelastographic microscopy using photoacoustic damped oscillation effect

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