Photoacoustic tomography of ex vivo mouse hearts with myocardial infarction

Holotta, Markus; Grossauer, Harald; Kremser, Christian; Torbica, Pavle; Völkl, Jakob; Degenhart, Gerald; Esterhammer, Regina; Nuster, Robert; Paltauf, Guenther; Jaschke, Werner

doi:10.1117/1.3556720

Cited by 11 publications

(13 citation statements)

References 14 publications

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“…18 Nevertheless, many diseases and physiological processes usually manifest little or insufficient intrinsic PAT contrast. Therefore, it is highly essential and required to develop functional contrast agents for fully utilizing PAT potentials.…”

Section: Introductionmentioning

confidence: 99%

Structural and functional photoacoustic molecular tomography aided by emerging contrast agents

2014

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Photoacoustic tomography (PAT) can offer structural, functional and molecular contrasts at scalable observation level. By ultrasonically overcoming the strong optical scattering, this imaging technology can reach centimeters penetration depth while retaining high spatial resolution in biological tissue. Recent extensive research has been focused on developing new contrast agents to improve the imaging sensitivity, specificity and efficiency. These emerging materials have substantially accelerated PAT applications in signal sensing, functional imaging, biomarker labeling and therapy monitoring etc. Here, the potentials of different optical probes as PAT contrast agents were elucidated. We first describe the instrumental embodiments and the measured functional parameters, then focus on emerging contrast agent-based PAT applications, and finally discuss the challenges and prospects.

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Section: Introductionmentioning

confidence: 99%

Structural and functional photoacoustic molecular tomography aided by emerging contrast agents

2014

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“…Thus far, PAT/MSOT has not been explored in clinical cardiac imaging to the best of our knowledge. However, experimental cardiac imaging using PAT/MSOT or PAM has been reported . The imaging modality may yield new insights into the cardiomyocytes and their life in vivo and further contribute to clinical imaging science and diagnosis.…”

Section: Caveats Challenges and Insights On The Diagnosis And Theramentioning

confidence: 99%

“…However, experimental cardiac imaging using PAT/MSOT or PAM has been reported. 298,302,[316][317][318][319][320] The imaging modality may yield new insights into the cardiomyocytes and their life in vivo and further contribute to clinical imaging science and diagnosis.…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research‐practice gaps, challenges, and insights

Zheng

Kros

2017

Medicinal Research Reviews

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To date, five cancer treatment modalities have been defined. The three traditional modalities of cancer treatment are surgery, radiotherapy, and conventional chemotherapy, and the two modern modalities include molecularly targeted therapy (the fourth modality) and immunotherapy (the fifth modality). The cardiotoxicity associated with conventional chemotherapy and radiotherapy is well known. Similar adverse cardiac events are resurging with the fourth modality. Aside from the conventional and newer targeted agents, even the most newly developed, immune‐based therapeutic modalities of anticancer treatment (the fifth modality), e.g., immune checkpoint inhibitors and chimeric antigen receptor (CAR) T‐cell therapy, have unfortunately led to potentially lethal cardiotoxicity in patients. Cardiac complications represent unresolved and potentially life‐threatening conditions in cancer survivors, while effective clinical management remains quite challenging. As a consequence, morbidity and mortality related to cardiac complications now threaten to offset some favorable benefits of modern cancer treatments in cancer‐related survival, regardless of the oncologic prognosis. This review focuses on identifying critical research‐practice gaps, addressing real‐world challenges and pinpointing real‐time insights in general terms under the context of clinical cardiotoxicity induced by the fourth and fifth modalities of cancer treatment. The information ranges from basic science to clinical management in the field of cardio‐oncology and crosses the interface between oncology and onco‐pharmacology. The complexity of the ongoing clinical problem is addressed at different levels. A better understanding of these research‐practice gaps may advance research initiatives on the development of mechanism‐based diagnoses and treatments for the effective clinical management of cardiotoxicity.

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“…6 Even better is a box-scan, consisting of three linear scans (in the directions upward, forward, and downward the sample). 10 The two or three reconstructed images are then superimposed. We used the box scan detector configuration in all examples discussed below.…”

Section: Applicationsmentioning

confidence: 99%

On the use of frequency-domain reconstruction algorithms for photoacoustic imaging

et al. 2011

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We investigate the use of a frequency-domain reconstruction algorithm based on the nonuniform fast Fourier transform (NUFFT) for photoacoustic imaging (PAI). Standard algorithms based on the fast Fourier transform (FFT) are computationally efficient, but compromise the image quality by artifacts. In our previous work we have developed an algorithm for PAI based on the NUFFT which is computationally efficient and can reconstruct images with the quality known from temporal backprojection algorithms. In this paper we review imaging qualities, such as resolution, signal-to-noise ratio, and the effects of artifacts in real-world situations. Reconstruction examples show that artifacts are reduced significantly. In particular, image details with a larger distance from the detectors can be resolved more accurately than with standard FFT algorithms.

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Photoacoustic tomography of ex vivo mouse hearts with myocardial infarction

Cited by 11 publications

References 14 publications

Structural and functional photoacoustic molecular tomography aided by emerging contrast agents

Structural and functional photoacoustic molecular tomography aided by emerging contrast agents

Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research‐practice gaps, challenges, and insights

On the use of frequency-domain reconstruction algorithms for photoacoustic imaging

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