Photoacoustics for listening to metal nanoparticle super-aggregates

Voti, R. Li; Leahu, Grigore; Sibilia, C.; Matassa, Roberto; Familiari, Giuseppe; Cerra, Sara; Salamone, Tommaso A.; Fratoddi, Ilaria

doi:10.1039/d1na00333j

Cited by 14 publications

(11 citation statements)

References 59 publications

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“…The FESEM shows AuNPs‐1 colloid with low diameter (10 ± 2) nm and well‐monodispersed particles. Therefore, we can evaluate its larger size in solution with respect to the others sample due to interactions and self‐aggregation phenomena [ 65 ] that can occur in suspension. These are induced by the different surface covering and the longer chain length of the thiols.…”

Section: Resultsmentioning

confidence: 99%

Hydrophilic Gold Nanoparticles as Anti‐PD‐L1 Antibody Carriers: Synthesis and Interface Properties

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Cerra

et al. 2022

Part & Part Syst Charact

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Amino and sulfonate ending groups thiols are used as functionalizing agents to stabilize of gold nanoparticles (AuNPs), obtaining hydrophilic AuNPs with a 10–20 nm diameter range and tunable surface charge. The nanomaterial is extensively characterized from a physicochemical point of view by UV–Vis and Fourier‐transform infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, synchrotron radiation X‐ray photoelectron spectroscopy (XPS), and dynamic light scattering to investigate the bonding between the two thiols and the metal surface. Systems are also biologically characterized on human multiforme glioblastoma T98G cells to understand their behavior in cell culture for biomedical applications. NMR and XPS studies evidence the presence of amino ending thiols with different chain lengths, 6‐amino‐1‐hexanethiol hydrochloride (6EA) or cysteamine (CY) and sodium 3‐mercapto‐1‐propanesulfonate (3MPS) on the metal surface: the relative molar ratio between the thiols bound to the AuNPs (3MPS/6EA or 3MPS/CY) is measured. On selected samples, the anti‐PD‐L1 antibody is loaded using AuNPs/antibody combination in a 2:1 weight ratio. Comparing different AuNPs concentrations (10 and 50 µg mL−1), the effect on colony‐forming capacity after 24 h exposure is evaluated. The synthesized AuNPs are nontoxic, and they do not affect cell proliferation. These small particles can be used for targeting, opening tangible and interesting perspectives for further biomedical studies.

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Section: Resultsmentioning

confidence: 99%

Hydrophilic Gold Nanoparticles as Anti‐PD‐L1 Antibody Carriers: Synthesis and Interface Properties

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Cartoni

Cerra

et al. 2022

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“…Other groups such as Wu et al [ 104 ] and Chang et al [ 105 ] have also utilized the magnetic properties of metals, gadolinium/bismuth, and manganese tungsten oxide, respectively, to provide simultaneous multimodal imaging and therapy for oncological purposes (see Table 2 ). Additionally, studies using low-frequency range PAI to track metallic nanoparticles and their aggregates, in this case, silver nanoparticles and zinc oxide, are available and can be further used to monitor individual scattering and absorption, specifically in the presence of multiple contrast agents [ 106 , 107 ].…”

Section: Contrast Agents For In Vivo Testingmentioning

confidence: 99%

Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging

et al. 2022

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The field of cancer theranostics has grown rapidly in the past decade and innovative ‘biosmart’ theranostic materials are being synthesized and studied to combat the fast growth of cancer metastases. While current state-of-the-art oncology imaging techniques have decreased mortality rates, patients still face a diminished quality of life due to treatment. Therefore, improved diagnostics are needed to define in vivo tumor growths on a molecular level to achieve image-guided therapies and tailored dosage needs. This review summarizes in vivo studies that utilize contrast agents within the field of photoacoustic imaging—a relatively new imaging modality—for tumor detection, with a special focus on imaging and transducer parameters. This paper also details the different types of contrast agents used in this novel diagnostic field, i.e., organic-based, metal/inorganic-based, and dye-based contrast agents. We conclude this review by discussing the challenges and future direction of photoacoustic imaging.

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“…The morphology, crystallinity, porosity, and void distribution at the nanometer scale, and the chemical composition, the oxidation state, and the optical response at the microscopic level are in fact required to properly understand the mechanical behavior of such systems. The theoretical and experimental investigation, merging bottom-up and top-down approaches, provided an explanation of the multifaceted topic of nanogranular material mechanics, a topic requiring a multi-technique approach [65,66].…”

Section: The Ag Ultrathin Porous Filmsmentioning

confidence: 99%

Mechanical Properties of Nanoporous Metallic Ultrathin Films: A Paradigmatic Case

et al. 2021

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Nanoporous ultrathin films, constituted by a slab less than 100 nm thick and a certain void volume fraction provided by nanopores, are emerging as a new class of systems with a wide range of possible applications, including electrochemistry, energy storage, gas sensing and supercapacitors. The film porosity and morphology strongly affect nanoporous films mechanical properties, the knowledge of which is fundamental for designing films for specific applications. To unveil the relationships among the morphology, structure and mechanical response, a comprehensive and non-destructive investigation of a model system was sought. In this review, we examined the paradigmatic case of a nanoporous, granular, metallic ultrathin film with comprehensive bottom-up and top-down approaches, both experimentals and theoreticals. The granular film was made of Ag nanoparticles deposited by gas-phase synthesis, thus providing a solvent-free and ultrapure nanoporous system at room temperature. The results, bearing generality beyond the specific model system, are discussed for several applications specific to the morphological and mechanical properties of the investigated films, including bendable electronics, membrane separation and nanofluidic sensing.

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Photoacoustics for listening to metal nanoparticle super-aggregates

Abstract: Photoacoustic detection signal has been used to build a new strategy to determine the mesoscale self-assembly of metal nanoparticles in terms of size distribution and aggregate packing density (metal nanoparticles...

Cited by 14 publications

References 59 publications

Hydrophilic Gold Nanoparticles as Anti‐PD‐L1 Antibody Carriers: Synthesis and Interface Properties

Hydrophilic Gold Nanoparticles as Anti‐PD‐L1 Antibody Carriers: Synthesis and Interface Properties

Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging

Mechanical Properties of Nanoporous Metallic Ultrathin Films: A Paradigmatic Case

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