Photoactivatable Targeting Methods

Highly Efficient Visible Light-Induced Ca2+ Chelation

“…23,24 In addition to being accompanied by the drawbacks of activation by UV light, these previously reported molecules suffer from low quantum yields, making them much less appealing for use. 25 Furthermore, they are limited in their fluorescence enhancement, rendering them less applicable in fluorescence-based probes. [26][27][28][29] While current BAPTA-based molecules provide a solid basis for effective Ca 2+ chelators, less phototoxic and more effective cages are needed.…”

“…40,41 This underscores the remarkable efficacy of our modified chelators in modulating Ca 2+ binding interactions. Initially, we dimerized a 5-methoxy-2-nitrophenol (24) with a 1,2-dibromoethane (25) to yield compound 26. Then, the two nitro groups in 26 were reduced to amines by hydrogen with Pd/C.…”