Photoactivated enediynes as targeted antitumoral agents: Efficient routes to antibody and gold nanoparticle conjugates

Falcone, Danielle; Li, Jane; Kale, Amit; Jones, Graham B.

doi:10.1016/j.bmcl.2007.12.045

Cited by 32 publications

(10 citation statements)

References 14 publications

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“…a trapping of cells Xowing through a microXuidic channel, b deformation of cells Xowing through the channel using divergent laser beams c, d refer to how the resulting net force diVers according to the position of the cells in relation to the laser axis e shows the distributions for two identical, but counterpropagating laser beams f indicates the disruption in the symmetry of the resulting force when the cell is displaced from the axis human cancer cell lines including squamous cell carcinoma of the larynx and found variability in the cell survival curves for the 4 chemotherapeutic agents tested with cisplatin and etoposide being the most eVective. Gold nanoparticles have already shown promise in the remit of detection and are far more eVective than existing techniques, such as ELISA [27,35] and with attachment of antibodies to gold nanoparticles selective binding to tumour cells has been possible with subsequent photoactivation [36]. Silicon-based nanowires have also been shown able to electrically detect tumour marker proteins and give a measured response [37].…”

Section: Future Directionsmentioning

confidence: 97%

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Nanomedicine in otorhinolaryngology: what does the future hold?

Philpott

Gane

McKiernan

2010

Eur Arch Otorhinolaryngol

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Nanotechnology and nanomedicine are new and rapidly developing areas which are concerned with the utilisation of structures and devices, one billionth of a metre in scale and how their special properties may be utilised in the diagnosis and treatment of diseases. In otorhinolaryngology, there have been some inroads into utilising these new treatment modalities and there is future prospect for significant developments. Their impact may be to revolutionise the current practice of otorhinolaryngology. This review considers current developments and future prospects for nanotechnology in our specialty and considers the pitfalls that may be encountered. The online medical reference databases PubMed, Google Scholar, ISI Web of Science and Science Direct were searched with search terms "Nanotechnology, Nanomedicine" in combination with "Otolaryngology, ENT, Rhinology, Otology, Head and Neck Surgery, Laryngology" in turn. A number of developments are already showing promise in animal models, particularly for nanoparticle delivery of drugs, which may avoid some of the inherent systemic side effects seen with conventional application. Other possibilities include nanoscale reconstruction and regeneration of tissues and even unexpected spin-off technologies such as haemostatic agents. The future treatment of otorhinolaryngological diseases could be revolutionised by advances in nanomedicine and nanotechnology and diseases, such as olfactory disorders may become radically more amenable to medical treatment.

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Section: Future Directionsmentioning

confidence: 97%

“…Nanoparticle photoablation heralds another nanotransportation technique that may allow targeting tumour cells by circulating prodrugs that require photoactivation [27]. The principle here is to use metal nanodots that would be activated by photons of light and heat the dots and subsequently their environs [3].…”

Section: Laryngology/head and Neckmentioning

confidence: 99%

Nanomedicine in otorhinolaryngology: what does the future hold?

Philpott

Gane

McKiernan

2010

Eur Arch Otorhinolaryngol

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“…Recently, Falcone et al [78] synthesized a series of functionalized simple aryl enediynes 81 -83 (Scheme 4). The building blocks were used to effect conjugation to carrier polyethylene glycol (PEG) templates 82, which allowed subsequent coupling to a cardiac-targeted monoclonal antibody, and the bioconjugates underwent successful photo-BC.…”

Section: 2mentioning

confidence: 99%

Recent Developments in Enediyne Chemistry

Joshi

Rawat

2012

Chemistry & Biodiversity

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The enediynes are known for highly potent anticancer, antimicrobial, as well as cytotoxic activities. The discovery of enediynes from natural sources was achieved in late 1980s. They are presently of high interest, because they exert their biological action due to their ability to form a diradical, which abstracts H-atoms from the DNA backbone, thus causing cell death. Nowadays, the major works are dedicated to the syntheses of enediynes. This review covers recent developments in enediyne chemistry of the last few decades. It is subdivided in six chapters dealing with the discussion of the chemistry and biological significances of enediynes, and the factors responsible for a better activation of enediynes and potent biological evaluations.

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“…Later, Turro and Nicolaou revealed that simple artificial enediynes could also undergo cycloaromatization upon photo‐irradiation 45. Subsequently, plenty of arene‐fused or nonbenzenoid, locked or acyclic enediynes were explored and investigated under photoirradiation 46–56. Photo‐Bergman cyclization was deemed to be similar in mechanism to that of the thermal induced.…”

Section: Introductionmentioning

confidence: 99%

A convergence of photo‐bergman cyclization and intramolecular chain collapse towards polymeric nanoparticles

Zhu

Qian

Xiao

et al. 2011

J. Polym. Sci. A Polym. Chem.

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Employing enediynes as crosslinking precursors, a novel yet efficient strategy, namely photo-triggered Bergman cyclization, was integrated with intramolecular chain collapse to yield polymeric nanoparticles with the size regime below 20 nm. Enediyne motif was designed delicately to possess a high photo-reactivity, with the double bond locked in a methyl benzoate ring while triple bonds substituted with phenyls. Single electron transfer-living radical polymerization was conducted to provide linear acrylate copolymers with controlled molecular weights and narrow polydispersities. Poly(butylarylate-co-5) went through UV-irradiation with a concurrent Bergman cyclization, resulting in well-defined ultrafine polymeric nanoparticles. Results from NMR, Raman scattering, photolumines-cence and UV-vis spectra corroborated the presence of conjugative structures in the polymeric nanoparticles, indicating the occurrence of photo-induced Bergman cyclization. A series of other acrylate-based nanoparticles were investigated to confirm the applicability of such a unique strategy in thermal sensitive but UV-stable polymeric structures, making photo-Bergman cyclization a promising tool towards polymeric nanoparticles. V C 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 5330-5338, 2011

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Photoactivated enediynes as targeted antitumoral agents: Efficient routes to antibody and gold nanoparticle conjugates

Cited by 32 publications

References 14 publications

Nanomedicine in otorhinolaryngology: what does the future hold?

Nanomedicine in otorhinolaryngology: what does the future hold?

Recent Developments in Enediyne Chemistry

A convergence of photo‐bergman cyclization and intramolecular chain collapse towards polymeric nanoparticles

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