Photoactive Self‐Shaping Hydrogels as Noncontact 3D Macro/Microscopic Photoprinting Platforms

Liao, Yue; An, Ning; Wang, Ning; Zhang, Yinyu; Song, Junfei; Zhou, Jinxiong; Liu, Wenguang

doi:10.1002/marc.201500390

Cited by 18 publications

(14 citation statements)

References 36 publications

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“…The Young's modulus of this hydrogel is hundreds of times higher than other reported photochemically shape changing hydrogels (Young's modulus ca. 8.5 kPa to 45 kPa) . While in contrast, the poly(MAA‐ co ‐OEGMA) lacking π–π interaction was observed to be a soft, tacky film measured with circa 0.1 MPa tensile stress and low Young's modulus of 0.9 MPa and could not be fractured even after stretching over 8000 % of its original size (Figure B).…”

Section: Resultsmentioning

confidence: 98%

Strong, Self‐Healable, and Recyclable Visible‐Light‐Responsive Hydrogel Actuators

et al. 2020

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The most pressing challenges for light-driven hydrogel actuators include reliance on UV light, slowresponse,poor mechanical properties,a nd limited functionalities.N ow, as upramolecular design strategy is used to address these issues.K ey is the use of ab enzylimine-functionalized anthracene group,w hich red-shifts the absorption into the visible region and also stabilizes the supramolecular network through p-p interactions.Acid-ether hydrogen bonds are incorporated for energy dissipation under mechanical deformation and maintaining hydrophilicity of the network. This double-crosslinked supramolecular hydrogel developed via as imple synthesis exhibits au nique combination of high strength, rapid self-healing,and fast visible-light-driven shape morphing both in the wet and dry state.Asall of the interactions are dynamic, the design enables the structures to be recycled and reprogrammed into different 3D objects.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

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Section: Resultsmentioning

confidence: 98%

Strong, Self‐Healable, and Recyclable Visible‐Light‐Responsive Hydrogel Actuators

et al. 2020

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“…Preparation of Locally UV‐Reduced GO‐PNIPAM 2D Macroscopically Anisotropic Biresponsive Polymer Hydrogel (2D MA‐SPH) : The GO‐PNIPAM hydrogel sheet was covered with a mask and then the uncovered area was locally reduced through UV light (254 nm, 1.1 mW cm −2 ) unilaterally irradiating from up to down. After 24 h, the locally reduced RGO‐PNIPAM hydrogel was taken out and owned photothermo/thermo dual‐responsive 3D complex deformation . All of the original GO‐PNIPAM hydrogel sheets were 0.5 mm thick.…”

Section: Methodsmentioning

confidence: 99%

A Multiresponsive Anisotropic Hydrogel with Macroscopic 3D Complex Deformations

Ma¹,

Le²,

Tang

et al. 2016

Adv Funct Materials

232

169

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wileyonlinelibrary.comWhile considerable progress of 2D deformation of SPHs has been achieved, [15][16][17][18][19][20][21][22][23] the realization of 3D or even more complex deformation still remains a significant challenge. Currently, there are two main approaches to achieve 3D complex deformations/movements of SPHs by imposing external nonuniform stimuli [24,25] or through the preparation of internal anisotropic hydrogels. [26,27] Due to the difficulty of applying most of the nonuniform external stimuli precisely onto a SPHs system, an alternative strategy of fabricating macroscopically anisotropic SPHs (MA-SPHs) has been explored as the popular way to realize complex 3D deformation. [26,27] These SPHs can accomplish diverse complex deformations directly under uniform stimuli owing to the heterogeneous responsiveness of anisotropic structures.Complex 3D deformation of the MA-SPHs could be achieved through the fabrication of differential cross-linking density [28][29][30] or a local secondnetwork [31][32][33][34][35] and subsequently applying external stimuli inside the hydrogels. For example, Sharon and co-workers have reported an early example to prepare a 2D anisotropic hydrogel sheet with laterally nonuniform cross-linking density to realize the 3D buckling or wrinkling. [28] Hayward and co-workers have introduced cross-linked stimulus-responsive polymers with UV-induced patterning to fabricate 2D hydrogel sheets with precisely controllable 3D bucklings. [29] Using a similar strategy, Wu et al. have developed an anisotropic 2D gel sheet with a tunable second-network to achieve 3D spiralings or curlings. [31] Besides UV cross-linking, an "electrically assisted ionoprinting" technique could also be utilized to form a local second-network and to attain 3D complex deformations. [32,34] Despite the recent progress of 3D complex deformation of MA-SPHs, the lack of remote-controllability during the deformation process strongly limits their application in some special fields, where solution-wide changes or invasive wires or electrodes are not permitted.With excellent photothermal conversion efficiency, [36] graphene sheets are well known as good candidates to obtain remote-controllable light-responsive deformations. However, they cannot be homodispersed in hydrogel directly because of their hydrophobic nature. Alternatively, graphene oxide sheets (GOs) can be well dispersed in hydrogels and can be reduced in situ using UV irradiation to attain reduced GOs (RGOs). Therefore, remote-controllable light-responsive deformations of As one of the most promising smart materials, stimuli-responsive polymer hydrogels (SPHs) can reversibly change volume or shape in response to external stimuli. They thus have shown promising applications in many fields. While considerable progress of 2D deformation of SPHs has been achieved, the realization of 3D or even more complex deformation still remains a significant challenge. Here, a general strategy towards designing multiresponsive, macroscopically anisotropic SPHs (MA-SPHs) with th...

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“…This hydrogel is capable of self-shaping directly to the UV irradiation. It is designable by using selective illumination to UV light with the specific area covered with darkness (Figure 6) (Liao et al, 2015). The printable hydrogel is an inspiring design for controlled drug delivery with district distribution.…”

Section: Photosensitive Hydrogelsmentioning

confidence: 99%

Injectable Hydrogels for Localized Cancer Therapy

2019

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Traditional intravenous chemotherapy is relative to many systemic side effects, including myelosuppression, liver or kidney dysfunction, and neurotoxicity. As an alternative method, the injectable hydrogel can efficiently avoid these problems by releasing drugs topically at the tumor site. With advantages of localized drug toxicity in the tumor site, proper injectable hydrogel as the drug delivery system has become a research hotspot. Based on different types and stages of cancer, a variety of hydrogel drug delivery systems were developed, including thermosensitive, pH-sensitive, photosensitive, and dual-sensitive hydrogel. In this review, the latest developments of these hydrogels and related drug delivery systems were summarized. In summary, our increasing knowledge of injectable hydrogel for localized cancer therapy ensures us that it is a more durable and effective approach than traditional chemotherapy. Smart release system reacting to different stimuli at different time according to the micro-environment changes in the tumor site is a promising tendency for further studies.

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Photoactive Self‐Shaping Hydrogels as Noncontact 3D Macro/Microscopic Photoprinting Platforms

Cited by 18 publications

References 36 publications

Strong, Self‐Healable, and Recyclable Visible‐Light‐Responsive Hydrogel Actuators

Strong, Self‐Healable, and Recyclable Visible‐Light‐Responsive Hydrogel Actuators

A Multiresponsive Anisotropic Hydrogel with Macroscopic 3D Complex Deformations

Injectable Hydrogels for Localized Cancer Therapy

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