Photoallergische Ekzeme durch Mycanodin

Role of <i>in viv</i><i>o</i>- and <i>in vitr</i><i>o</i>-formed Decomposition Products of Sulfanilamides and Phenothiazines in Photoallergy; Relationship of Spectrophotometric Findings to <i>in vivo</i> Reactions

“…have shown that this product actually occurs in small concentrations by in vitro irradiation of sulfanilamide (24). Our 2 retested sulfanilamide cases reacted negatively to PHABSA; however, Burckhardt et al demonstrated that humans photoallergic to the oral antidiabetic, N1-Sulfanilyl-N2-n-butyl-carbamid (Nadisan), a sulfonamide pro duct, reacted to PHABSA as well (6). Other possible oxidation pro ducts mentioned by T horpe and Williams (2-Oxy-benzoxazol-6-sulfonamide, and l-Amino-3-hydroxy-benzene-4 -sulfonamide), were tested for their sensitizing ability; however, they did not demonstrate eczematogenic properties upon guinea-pigs (29,30).…”

Influence of Ultraviolet Irradiation on the Surface Activity of Phenothiazine Drugs

“…Reports of an increased soybean yield following the use of the plant growth regulator, 2,3,5-triiodobenzoic acid (I) (1-3) have led to a proposal for widespread use of the compound on soybeans (4). A more recent publication, dealing with the residue properties of I-14C-2,3,5-triiodobenzoic acid (11) (5), reported that 14C activity was lost rapidly from the plant but that a residue containing 14C was detected in the harvested seeds.…”

Drug Photoallergy

“…Patients with sulfanilamide photoallergy react to 4-hydroxyaminobenzene sulfonamide in the dark. 39,46 According to the alternate theory, photoallergy depend s on the interaction betwee n photoexcited states and cutaneous proteins. A number of photoallergens including TCSA, 47 Jadit 42 and triacetyldiphenolisatin 48 form free radi c alst on irradiation.…”