Photobiomodulation can improve ovarian activity in polycystic ovary syndrome-induced rats

Alves, Eduardo Donato; Bonfá, Ana Lúcia Oliveira; Pigatto, Glauce Regina; Anselmo-Franci, Janete Aparecida; Achcar, Jorge Alberto; Parizotto, Nivaldo Antônio; Montrezor, Luís Henrique

doi:10.1016/j.jphotobiol.2019.03.006

Cited by 13 publications

(3 citation statements)

References 44 publications

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“…Such alterations, observed using daily vaginal smears, were in agreement with the morphological alterations of the ovaries. All the animals of the PCO groups showed reductions of the numbers of secondary and tertiary follicles, as well as corpora lutea, while there were increases of the numbers of ovarian cysts and atretic follicles (data not shown), similar to our previous observations 15,31 . These results suggested that the ovarian alterations related to the increase in T production, due to possible enzymatic alterations, were the probable cause of the ovarian morphological changes that altered the estrous cycles in the rats induced to PCOS by EV.…”

Section: Discussionsupporting

confidence: 90%

Simultaneous alterations in ovaries and bone as a result of Polycystic Ovary Syndrome

Bonfá

Alves

Fabrício

et al. 2021

IJAMB

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Polycystic ovary syndrome (PCOS) is one of the most widely recognized endocrine disorders affecting reproductive-age women. The etiopathogenesis and mechanisms of this syndrome remain unclear. Diagnosis requires two of the following: polycystic ovaries, oligo- or anovulation, and hyperandrogenism. Most women with PCOS display conditions such as metabolic abnormalities, diabetes, obesity, cardiovascular disease, and/or bone dysfunction. Considering the ethical limitations of human studies, animal and cell culture models that reflect some features of PCOS are important for investigation of this syndrome. The aim of the present work was to study some of the endocrine relationships between ovaries and bone tissue in a polycystic ovary syndrome animal model. The study was performed using an estradiol valerate PCOS-induced rat model (n = 30) and bone mesenchymal stem cell cultured from bone marrow of those animals. It was hypothesized that changes of the endocrine relationship between ovaries and bones could be observed in from in vivo animal model and in vitro cell culture assays. The ovarian morphological and endocrine changes seem to be correlated with endocrine, biophysical, and biomechanical changes in bone properties. Mesenchymal stem cells obtained from PCOS-induced rats, cultured for up to 21 days and differentiated into osteoblasts, presented lower viability and reduced mineralization of the extracellular matrix. Taken together, these results indicate important endocrine and structural effects of PCOS in ovaries and bones, contributing to part of the understanding of the pathophysiological mechanisms of PCOS.

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Section: Discussionsupporting

confidence: 90%

Simultaneous alterations in ovaries and bone as a result of Polycystic Ovary Syndrome

Bonfá

Alves

Fabrício

et al. 2021

IJAMB

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“…Finally, photobiomodulation therapy (PBMT) with low-level laser light therapy (LLLT) is known to exert its rejuvenative effects via targeting the chromophore cytochrome C oxidase in mitochondrial membrane ( 119 ). In two rodent studies, PBMT is shown to increase the number of primary and pre-antral follicle count ( 120 , 121 ), to decrease granulosa cell apoptosis and to increase angiogenesis; however, it was not shown to increase the number of Pfs ( 120 ).…”

Section: Mitochondrial-targeting Therapiesmentioning

confidence: 99%

Biological therapies for premature ovarian insufficiency: what is the evidence?

Moustaki,

Kontogeorgi,

Tsangkalova

et al. 2023

Front. Reprod. Health

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Premature Ovarian Insufficiency (POI) is a multi-factorial disorder that affects women of reproductive age. The condition is characterized by the loss of ovarian function before the age of 40 years and several factors have been identified to be implicated in its pathogenesis. Remarkably though, at least 50% of women have remaining follicles in their ovaries after the development of ovarian insufficiency. Population data show that approximately up to 3.7% of women worldwide suffer from POI and subsequent infertility. Currently, the treatment of POI-related infertility involves oocyte donation. However, many women with POI desire to conceive with their own ova. Therefore, experimental biological therapies, such as Platelet-Rich Plasma (PRP), Exosomes (exos) therapy, In vitro Activation (IVA), Stem Cell therapy, MicroRNAs and Mitochondrial Targeting Therapies are experimental treatment strategies that focus on activating oogenesis and folliculogenesis, by upregulating natural biochemical pathways (neo-folliculogenesis) and improving ovarian microenvironment. This mini-review aims at identifying the main advantages of these approaches and exploring whether they can underpin existing assisted reproductive technologies.

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“…Naseri et al indicated that near-infrared laser can increase ovarian activity to produce oocyte [166]. Besides, treatment of EV-induced PCOS rats with 808 nm laser reduces the number of follicular cysts and increases the number of follicles [167]. Although there are scarce clinical data on this area, still it deserves further exploration.…”

Section: Othersmentioning

confidence: 99%

Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites

Chen

Pang

2021

Metabolites

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance (IR) and hyperandrogenism. The underlying pathogenesis of these metabolic symptoms has not yet been fully elucidated. With the application of metabolomics techniques, a variety of metabolite changes have been observed in the serum and follicular fluid (FF) of PCOS patients and animal models. Changes in metabolites result from the daily diet and occur during uncommon physiological routines. However, some of these metabolite changes may provide evidence to explain possible mechanisms and new approaches for prevention and therapy. This article reviews the pathogenesis of PCOS metabolic symptoms and the relationship between metabolites and the pathophysiology of PCOS. Furthermore, the potential clinical application of some specific metabolites will be discussed.

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Photobiomodulation can improve ovarian activity in polycystic ovary syndrome-induced rats

Cited by 13 publications

References 44 publications

Simultaneous alterations in ovaries and bone as a result of Polycystic Ovary Syndrome

Simultaneous alterations in ovaries and bone as a result of Polycystic Ovary Syndrome

Biological therapies for premature ovarian insufficiency: what is the evidence?

Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites

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