Photobiomodulation effects of blue light on osteogenesis are induced by reactive oxygen species

Exposure of Bladder Cancer Cells to Blue Light (λ = 453 nm) in the Presence of Riboflavin Synergistically Enhances the Cytotoxic Efficiency of Gemcitabine

“…However, cytotoxic events were clearly demonstrated in cell cultures exposed to blue light in the presence of riboflavin. In SW-1710 and BFTC-905 cultures, exposure to blue light in the presence of 10, 20 or 25 µM riboflavin resulted in a statistically significant increase in cytotoxicity compared with the values observed after irradiation of the respective cell (50,80,110,140,200, 300 J/cm 2 ). Twenty-four hours after light exposure, the number of living cells was detected by CTB assay.…”

“…With increasing advances in the field of laser and LED technology, light in its entire spectrum, from ultraviolet to deep infrared, represents an interesting, specific and effective medium for combination therapies [45][46][47]. The therapy-improving potential of light applications, possibly also in combination with suitable photosensitisers, is based on the light-induced generation of reactive oxygen species (ROS), which contributes synergistically or additively to increasing the cytotoxic potential of a chemotherapeutic agent by increasing the intracellular or extracellular oxidative stress [48][49][50][51]. Thus, increasing the therapeutic effect by using photodynamic therapy methods represents one such new therapeutic option.…”

“…We decided to use this subtoxic dose to distinguish better between the effect of blue light and the other substances we were using during the following experiments. (50,80,110,140,200, 300 J/cm 2 ). Twenty-four hours after light exposure, the number of living cells was detected by CTB assay.…”

“…Impact of blue light exposure on viability of urothelial carcinoma cells. Urothelial carcinoma cell line cultures (BFTC-905; RT-112; SW-1710) were irradiated with blue light (l = 453 nm) at light doses indicated(50,80,110, 140, 200, 300 J/cm 2 ). Twenty-four hours after light exposure, the number of living cells was detected by CTB assay.…”